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Items: 1 to 20 of 24

1.

Enzymatic Preparation of 2'-5',3'-5'-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations.

Novotná B, Vaneková L, Zavřel M, Buděšínský M, Dejmek M, Smola M, Gutten O, Tehrani ZA, Pimková Polidarová M, Brázdová A, Liboska R, Štěpánek I, Vavřina Z, Jandušík T, Nencka R, Rulíšek L, Bouřa E, Brynda J, Páv O, Birkuš G.

J Med Chem. 2019 Dec 12;62(23):10676-10690. doi: 10.1021/acs.jmedchem.9b01062. Epub 2019 Nov 27.

PMID:
31715099
2.

Solid-Phase Synthesis of Phosphorothioate/Phosphonothioate and Phosphoramidate/Phosphonamidate Oligonucleotides.

Kostov O, Liboska R, Páv O, Novák P, Rosenberg I.

Molecules. 2019 May 15;24(10). pii: E1872. doi: 10.3390/molecules24101872.

3.

The benchmark of 31P NMR parameters in phosphate: a case study on structurally constrained and flexible phosphate.

Fukal J, Páv O, Buděšínský M, Šebera J, Sychrovský V.

Phys Chem Chem Phys. 2017 Dec 6;19(47):31830-31841. doi: 10.1039/c7cp06969c.

PMID:
29171602
4.

Nucleoside-O-Methyl-(H)-Phosphinates: Novel Monomers for the Synthesis of Methylphosphonate Oligonucleotides Using H-Phosphonate Chemistry.

Kostov O, Páv O, Rosenberg I.

Curr Protoc Nucleic Acid Chem. 2017 Sep 18;70:4.76.1-4.76.22. doi: 10.1002/cpnc.35.

PMID:
28921496
5.

Tuning the hybridization properties of modified oligonucleotides: from flexible to conformationally constrained phosphonate internucleotide linkages.

Páv O, Barvík I, Liboska R, Petrová M, Šimák O, Rosenbergová Š, Novák P, Buděšínský M, Rosenberg I.

Org Biomol Chem. 2017 Jan 18;15(3):701-707. doi: 10.1039/c6ob02571d.

PMID:
27995239
6.

4-Toluenesulfonyloxymethyl-(H)-phosphinate: A Reagent for the Introduction of O- and S-Methyl-(H)-phosphinate Moieties.

Kostov O, Páv O, Buděšínský M, Liboska R, Šimák O, Petrová M, Novák P, Rosenberg I.

Org Lett. 2016 Jun 3;18(11):2704-7. doi: 10.1021/acs.orglett.6b01167. Epub 2016 May 13.

PMID:
27177076
7.

Crystal structure of Mycobacterium tuberculosis O6-methylguanine-DNA methyltransferase protein clusters assembled on to damaged DNA.

Miggiano R, Perugino G, Ciaramella M, Serpe M, Rejman D, Páv O, Pohl R, Garavaglia S, Lahiri S, Rizzi M, Rossi F.

Biochem J. 2016 Jan 15;473(2):123-33. doi: 10.1042/BJ20150833. Epub 2015 Oct 28.

PMID:
26512127
8.

Vibrational Properties of the Phosphate Group Investigated by Molecular Dynamics and Density Functional Theory.

Andrushchenko V, Benda L, Páv O, Dračínský M, Bouř P.

J Phys Chem B. 2015 Aug 20;119(33):10682-92. doi: 10.1021/acs.jpcb.5b05124. Epub 2015 Aug 5.

PMID:
26193890
9.

Straightforward Synthesis of Purine 4'-Alkoxy-2'-deoxynucleosides: First Report of Mixed Purine-Pyrimidine 4'-Alkoxyoligodeoxynucleotides as New RNA Mimics.

Petrová M, Páv O, Buděšínský M, Zborníková E, Novák P, Rosenbergová Š, Pačes O, Liboska R, Dvořáková I, Šimák O, Rosenberg I.

Org Lett. 2015 Jul 17;17(14):3426-9. doi: 10.1021/acs.orglett.5b01430. Epub 2015 Jul 2.

PMID:
26133076
10.

N-Branched acyclic nucleoside phosphonates as monomers for the synthesis of modified oligonucleotides.

Hocková D, Rosenbergová Š, Ménová P, Páv O, Pohl R, Novák P, Rosenberg I.

Org Biomol Chem. 2015 Apr 21;13(15):4449-58. doi: 10.1039/c4ob02265c.

PMID:
25766752
11.

Theoretical and experimental study of charge transfer through DNA: impact of mercury mediated T-Hg-T base pair.

Kratochvílová I, Golan M, Vala M, Špérová M, Weiter M, Páv O, Šebera J, Rosenberg I, Sychrovský V, Tanaka Y, Bickelhaupt FM.

J Phys Chem B. 2014 May 22;118(20):5374-81. doi: 10.1021/jp501986a. Epub 2014 May 7.

PMID:
24780102
12.

5'-O-Methylphosphonate nucleic acids--new modified DNAs that increase the Escherichia coli RNase H cleavage rate of hybrid duplexes.

Šipova H, Špringer T, Rejman D, Šimak O, Petrová M, Novák P, Rosenbergová Š, Páv O, Liboska R, Barvík I, Štěpanek J, Rosenberg I, Homola J.

Nucleic Acids Res. 2014 Apr;42(8):5378-89. doi: 10.1093/nar/gku125. Epub 2014 Feb 12.

13.

Inhibition of human thymidine phosphorylase by conformationally constrained pyrimidine nucleoside phosphonic acids and their "open-structure" isosteres.

Košiová I, Šimák O, Panova N, Buděšínský M, Petrová M, Rejman D, Liboska R, Páv O, Rosenberg I.

Eur J Med Chem. 2014 Mar 3;74:145-68. doi: 10.1016/j.ejmech.2013.12.026. Epub 2014 Jan 3.

PMID:
24462848
14.

Charge transfer through DNA/DNA duplexes and DNA/RNA hybrids: complex theoretical and experimental studies.

Kratochvílová I, Vala M, Weiter M, Špérová M, Schneider B, Páv O, Šebera J, Rosenberg I, Sychrovský V.

Biophys Chem. 2013 Oct-Nov;180-181:127-34. doi: 10.1016/j.bpc.2013.07.009. Epub 2013 Jul 31.

PMID:
23968861
15.

Structural changes of human RNase L upon homodimerization investigated by Raman spectroscopy.

Kříž M, Snášel J, Kopecký V Jr, Páv O, Rosenberg I, Stěpánek J.

Biochim Biophys Acta. 2012 Sep;1824(9):1039-44. doi: 10.1016/j.bbapap.2012.06.002. Epub 2012 Jun 9.

PMID:
22691533
16.

Activation of human RNase L by 2'- and 5'-O-methylphosphonate-modified oligoadenylates.

Páv O, Panova N, Snášel J, Zborníková E, Rosenberg I.

Bioorg Med Chem Lett. 2012 Jan 1;22(1):181-5. doi: 10.1016/j.bmcl.2011.11.040. Epub 2011 Nov 23.

PMID:
22169265
17.

4'-Alkoxy oligodeoxynucleotides: a novel class of RNA mimics.

Liboska R, Snášel J, Barvík I, Buděšínský M, Pohl R, Točík Z, Páv O, Rejman D, Novák P, Rosenberg I.

Org Biomol Chem. 2011 Dec 21;9(24):8261-7. doi: 10.1039/c1ob06148h. Epub 2011 Nov 3.

PMID:
22051918
18.

Synthesis of oligoribonucleotides with phosphonate-modified linkages.

Páv O, Košiová I, Barvík I, Pohl R, Buděšínský M, Rosenberg I.

Org Biomol Chem. 2011 Sep 7;9(17):6120-6. doi: 10.1039/c1ob05488k. Epub 2011 Jul 18.

PMID:
21769370
19.

Structural diversity of nucleoside phosphonic acids as a key factor in the discovery of potent inhibitors of rat T-cell lymphoma thymidine phosphorylase.

Kocalka P, Rejman D, Vanek V, Rinnová M, Tomecková I, Králíková S, Petrová M, Páv O, Pohl R, Budesínský M, Liboska R, Tocík Z, Panova N, Votruba I, Rosenberg I.

Bioorg Med Chem Lett. 2010 Feb 1;20(3):862-5. doi: 10.1016/j.bmcl.2009.12.081. Epub 2009 Dec 28.

PMID:
20053558
20.

Nucleoside phosphonic acids in thymidine phosphorylase inhibition: structure-activity relationship.

Panova N, Kosiová I, Petrová M, Vanĕk V, Liboska R, Kovacková S, Kocalka P, Králíková S, Tocík Z, Páv O, Paces O, Rejman D, Rosenberg I.

Nucleic Acids Symp Ser (Oxf). 2008;(52):665-6. doi: 10.1093/nass/nrn336.

PMID:
18776555

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