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Items: 12

1.

Synthesis of Terminal Ribose Analogues of Adenosine 5'-Diphosphate Ribose as Probes for the Transient Receptor Potential Cation Channel TRPM2.

Baszczyňski O, Watt JM, Rozewitz MD, Guse AH, Fliegert R, Potter BVL.

J Org Chem. 2019 May 17;84(10):6143-6157. doi: 10.1021/acs.joc.9b00338. Epub 2019 May 7.

2.

Synthesis and anti-human immunodeficiency virus activity of substituted ( o,o-difluorophenyl)-linked-pyrimidines as potent non-nucleoside reverse transcriptase inhibitors.

Čechová L, Dejmek M, Baszczyňski O, Šaman D, Gao L, Hu E, Stepan G, Jansa P, Janeba Z, Šimon P.

Antivir Chem Chemother. 2019 Jan-Dec;27:2040206619826265. doi: 10.1177/2040206619826265.

3.

Reactive cyclic intermediates in the ProTide prodrugs activation: trapping the elusive pentavalent phosphorane.

Procházková E, Navrátil R, Janeba Z, Roithová J, Baszczyňski O.

Org Biomol Chem. 2019 Jan 2;17(2):315-320. doi: 10.1039/c8ob02870b.

PMID:
30543240
4.

Xanthine-based acyclic nucleoside phosphonates with potent antiviral activity against varicella-zoster virus and human cytomegalovirus.

Baszczyňski O, Kaiser MM, Česnek M, Břehová P, Jansa P, Procházková E, Dračínský M, Snoeck R, Andrei G, Janeba Z.

Antivir Chem Chemother. 2018 Jan-Dec;26:2040206618813050. doi: 10.1177/2040206618813050.

5.

Acyclic Nucleoside Phosphonates Containing 9-Deazahypoxanthine and a Five-Membered Heterocycle as Selective Inhibitors of Plasmodial 6-Oxopurine Phosphoribosyltransferases.

Kaiser MM, Baszczyňski O, Hocková D, Poštová-Slavětínská L, Dračínský M, Keough DT, Guddat LW, Janeba Z.

ChemMedChem. 2017 Jul 20;12(14):1133-1141. doi: 10.1002/cmdc.201700293. Epub 2017 Jul 11.

PMID:
28628279
6.

Novel (2,6-difluorophenyl)(2-(phenylamino)pyrimidin-4-yl)methanones with restricted conformation as potent non-nucleoside reverse transcriptase inhibitors against HIV-1.

Šimon P, Baszczyňski O, Šaman D, Stepan G, Hu E, Lansdon EB, Jansa P, Janeba Z.

Eur J Med Chem. 2016 Oct 21;122:185-195. doi: 10.1016/j.ejmech.2016.06.026. Epub 2016 Jun 17.

PMID:
27371922
7.

Medicinal chemistry of fluorinated cyclic and acyclic nucleoside phosphonates.

Baszczyňski O, Janeba Z.

Med Res Rev. 2013 Nov;33(6):1304-44. doi: 10.1002/med.21296. Epub 2013 Jul 24. Review.

PMID:
23893552
8.

The effect of novel [3-fluoro-(2-phosphonoethoxy)propyl]purines on the inhibition of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases.

Baszczyňski O, Hocková D, Janeba Z, Holý A, Jansa P, Dračínský M, Keough DT, Guddat LW.

Eur J Med Chem. 2013 Sep;67:81-9. doi: 10.1016/j.ejmech.2013.06.032. Epub 2013 Jun 22.

PMID:
23850568
9.

An enzymatic glycosylation of nucleoside analogues using β-galactosidase from Escherichia coli.

Blažek J, Jansa P, Baszczyňski O, Kaiser MM, Otmar M, Krečmerová M, Drančínský M, Holý A, Králová B.

Bioorg Med Chem. 2012 May 1;20(9):3111-8. doi: 10.1016/j.bmc.2012.02.062. Epub 2012 Mar 15.

PMID:
22465858
10.

Synthesis of 9-phosphonoalkyl and 9-phosphonoalkoxyalkyl purines: evaluation of their ability to act as inhibitors of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases.

Česnek M, Hocková D, Holý A, Dračínský M, Baszczyňski O, Jersey Jd, Keough DT, Guddat LW.

Bioorg Med Chem. 2012 Jan 15;20(2):1076-89. doi: 10.1016/j.bmc.2011.11.034. Epub 2011 Dec 1.

PMID:
22178188
11.

A novel and efficient one-pot synthesis of symmetrical diamide (bis-amidate) prodrugs of acyclic nucleoside phosphonates and evaluation of their biological activities.

Jansa P, Baszczyňski O, Dračínský M, Votruba I, Zídek Z, Bahador G, Stepan G, Cihlar T, Mackman R, Holý A, Janeba Z.

Eur J Med Chem. 2011 Sep;46(9):3748-54. doi: 10.1016/j.ejmech.2011.05.040. Epub 2011 May 23.

PMID:
21664011
12.

Synthesis and antiviral activity of N9-[3-fluoro-2-(phosphonomethoxy)propyl] analogues derived from N6-substituted adenines and 2,6-diaminopurines.

Baszczyňski O, Jansa P, Dračínský M, Klepetářová B, Holý A, Votruba I, de Clercq E, Balzarini J, Janeba Z.

Bioorg Med Chem. 2011 Apr 1;19(7):2114-24. doi: 10.1016/j.bmc.2011.02.050. Epub 2011 Mar 4.

PMID:
21429755

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