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Items: 1 to 20 of 120


Implication of human drug transporters to toxicokinetics and toxicity of pesticides.

Guéniche N, Bruyere A, Le Vée M, Fardel O.

Pest Manag Sci. 2019 Aug 8. doi: 10.1002/ps.5577. [Epub ahead of print] Review.


Neonicotinoid pesticides poorly interact with human drug transporters.

Le Vée M, Bacle A, Bruyere A, Fardel O.

J Biochem Mol Toxicol. 2019 Jul 31:e22379. doi: 10.1002/jbt.22379. [Epub ahead of print]


Induction of multidrug resistance-associated protein 3 expression by diesel exhaust particle extract in human bronchial epithelial BEAS-2B cells.

Le Vée M, Bacle A, Jouan E, Lecureur V, Potin S, Fardel O.

Toxicol In Vitro. 2019 Aug;58:60-68. doi: 10.1016/j.tiv.2019.03.021. Epub 2019 Mar 19.


Membrane transporter data to support kinetically-informed chemical risk assessment using non-animal methods: Scientific and regulatory perspectives.

Clerbaux LA, Paini A, Lumen A, Osman-Ponchet H, Worth AP, Fardel O.

Environ Int. 2019 May;126:659-671. doi: 10.1016/j.envint.2019.03.003. Epub 2019 Mar 8. Review.


An integrated functional and transcriptomic analysis reveals that repeated exposure to diesel exhaust induces sustained mitochondrial and cardiac dysfunctions.

Karoui A, Crochemore C, Mulder P, Preterre D, Cazier F, Dewaele D, Corbière C, Mekki M, Vendeville C, Richard V, Vaugeois JM, Fardel O, Sichel F, Lecureur V, Monteil C.

Environ Pollut. 2019 Mar;246:518-526. doi: 10.1016/j.envpol.2018.12.049. Epub 2018 Dec 17.


mRNA Expression and Activity of Nucleoside Transporters in Human Hepatoma HepaRG Cells.

Mayati A, Moreau A, Jouan E, Febvre-James M, Denizot C, Parmentier Y, Fardel O.

Pharmaceutics. 2018 Nov 21;10(4). pii: E246. doi: 10.3390/pharmaceutics10040246.


Efferocytosis capacities of blood monocyte-derived macrophages in systemic sclerosis.

Ballerie A, Lescoat A, Augagneur Y, Lelong M, Morzadec C, Cazalets C, Jouneau S, Fardel O, Vernhet L, Jégo P, Lecureur V.

Immunol Cell Biol. 2019 Mar;97(3):340-347. doi: 10.1111/imcb.12217. Epub 2018 Dec 13.


Functional polarization of human hepatoma HepaRG cells in response to forskolin.

Mayati A, Moreau A, Le Vée M, Bruyère A, Jouan E, Denizot C, Parmentier Y, Fardel O.

Sci Rep. 2018 Oct 31;8(1):16115. doi: 10.1038/s41598-018-34421-8.


M1/M2 polarisation state of M-CSF blood-derived macrophages in systemic sclerosis.

Lescoat A, Ballerie A, Jouneau S, Fardel O, Vernhet L, Jego P, Lecureur V.

Ann Rheum Dis. 2018 Sep 29. pii: annrheumdis-2018-214333. doi: 10.1136/annrheumdis-2018-214333. [Epub ahead of print] No abstract available.


Inhibition of organic cation transporter (OCT) activities by carcinogenic heterocyclic aromatic amines.

Sayyed K, Camillerapp C, Le Vée M, Bruyère A, Nies AT, Abdel-Razzak Z, Fardel O.

Toxicol In Vitro. 2019 Feb;54:10-22. doi: 10.1016/j.tiv.2018.08.015. Epub 2018 Sep 3.


Evaluation of Drug Biliary Excretion Using Sandwich-Cultured Human Hepatocytes.

Fardel O, Moreau A, Le Vée M, Denizot C, Parmentier Y.

Eur J Drug Metab Pharmacokinet. 2019 Feb;44(1):13-30. doi: 10.1007/s13318-018-0502-x. Review.


Cigarette smoke condensate alters Saccharomyces cerevisiae efflux transporter mRNA and activity and increases caffeine toxicity.

Sayyed K, Le Vée M, Chamieh H, Fardel O, Abdel-Razzak Z.

Toxicology. 2018 Nov 1;409:129-136. doi: 10.1016/j.tox.2018.08.005. Epub 2018 Aug 15.


Interactions of pesticides with membrane drug transporters: implications for toxicokinetics and toxicity.

Chedik L, Bruyere A, Bacle A, Potin S, Le Vée M, Fardel O.

Expert Opin Drug Metab Toxicol. 2018 Jul;14(7):739-752. doi: 10.1080/17425255.2018.1487398. Epub 2018 Jun 20. Review.


New insights in the in vitro characterisation and molecular modelling of the P-glycoprotein inhibitory promiscuity.

Bocci G, Moreau A, Vayer P, Denizot C, Fardel O, Parmentier Y.

Eur J Pharm Sci. 2018 Aug 30;121:85-94. doi: 10.1016/j.ejps.2018.04.039. Epub 2018 Apr 28.


Distinct Properties of Human M-CSF and GM-CSF Monocyte-Derived Macrophages to Simulate Pathological Lung Conditions In Vitro: Application to Systemic and Inflammatory Disorders with Pulmonary Involvement.

Lescoat A, Ballerie A, Augagneur Y, Morzadec C, Vernhet L, Fardel O, Jégo P, Jouneau S, Lecureur V.

Int J Mol Sci. 2018 Mar 17;19(3). pii: E894. doi: 10.3390/ijms19030894.


Interactions of organophosphorus pesticides with solute carrier (SLC) drug transporters.

Chedik L, Bruyere A, Fardel O.

Xenobiotica. 2019 Mar;49(3):363-374. doi: 10.1080/00498254.2018.1442030. Epub 2018 Mar 6.


Carrier-mediated uptake of clonidine in cultured human lung cells.

Le Vée M, Jouan E, Fardel O.

Naunyn Schmiedebergs Arch Pharmacol. 2018 Apr;391(4):361-369. doi: 10.1007/s00210-018-1467-7. Epub 2018 Jan 19.


Comparative study of diesel and biodiesel exhausts on lung oxidative stress and genotoxicity in rats.

Douki T, Corbière C, Preterre D, Martin PJ, Lecureur V, André V, Landkocz Y, Pottier I, Keravec V, Fardel O, Moreira-Rebelo S, Pottier D, Vendeville C, Dionnet F, Gosset P, Billet S, Monteil C, Sichel F.

Environ Pollut. 2018 Apr;235:514-524. doi: 10.1016/j.envpol.2017.12.077. Epub 2018 Jan 8.


Repression of interferon β-regulated cytokines by the JAK1/2 inhibitor ruxolitinib in inflammatory human macrophages.

Febvre-James M, Lecureur V, Augagneur Y, Mayati A, Fardel O.

Int Immunopharmacol. 2018 Jan;54:354-365. doi: 10.1016/j.intimp.2017.11.032. Epub 2017 Dec 1.


The JAK1/2 Inhibitor Ruxolitinib Reverses Interleukin-6-Mediated Suppression of Drug-Detoxifying Proteins in Cultured Human Hepatocytes.

Febvre-James M, Bruyère A, Le Vée M, Fardel O.

Drug Metab Dispos. 2018 Feb;46(2):131-140. doi: 10.1124/dmd.117.078048. Epub 2017 Nov 21.

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