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Items: 1 to 20 of 21

1.

Design, synthesis and biological evaluation of novel 5-oxo-2-thioxoimidazolidine derivatives as potent androgen receptor antagonists.

Ivachtchenko AV, Ivanenkov YA, Mitkin OD, Vorobiev AA, Kuznetsova IV, Shevkun NA, Koryakova AG, Karapetian RN, Trifelenkov AS, Kravchenko DV, Veselov MS, Chufarova NV.

Eur J Med Chem. 2015 Jun 24;99:51-66. doi: 10.1016/j.ejmech.2015.05.039. Epub 2015 Jun 2.

PMID:
26046313
2.

Discovery of novel highly potent hepatitis C virus NS5A inhibitor (AV4025).

Ivachtchenko AV, Mitkin OD, Yamanushkin PM, Kuznetsova IV, Bulanova EA, Shevkun NA, Koryakova AG, Karapetian RN, Bichko VV, Trifelenkov AS, Kravchenko DV, Vostokova NV, Veselov MS, Chufarova NV, Ivanenkov YA.

J Med Chem. 2014 Sep 25;57(18):7716-30. doi: 10.1021/jm500951r. Epub 2014 Sep 9.

PMID:
25148100
3.

Novel oral anti-influenza drug candidate AV5080.

Ivachtchenko AV, Ivanenkov YA, Mitkin OD, Yamanushkin PM, Bichko VV, Shevkun NA, Karapetian RN, Leneva IA, Borisova OV, Veselov MS.

J Antimicrob Chemother. 2014 Jul;69(7):1892-902. doi: 10.1093/jac/dku074. Epub 2014 Apr 11.

PMID:
24729605
4.

Preclinical Development of ONC1-13B, Novel Antiandrogen for Prostate Cancer Treatment.

Ivachtchenko AV, Mitkin OD, Kudan EV, Rjahovsky AA, Vorobiev AA, Trifelenkov AS, Shevkun NA, Proskurina OV, Kravchenko DV, Karapetian RN.

J Cancer. 2014 Jan 21;5(2):133-42. doi: 10.7150/jca.7773. eCollection 2014.

5.

Novel oral anti-influenza prodrug candidate AV5075S.

Ivachtchenko AV, Ivanenkov YA, Mitkin OD, Yamanushkin PM, Bichko VV, Shevkun NA, Mokrushina OV, Nevolina OO, Karapetian RN, Leneva IA, Fedyakina IT, Veselov MS.

J Antimicrob Chemother. 2014 May;69(5):1311-24. doi: 10.1093/jac/dkt507. Epub 2014 Jan 15.

PMID:
24428978
6.

A novel influenza virus neuraminidase inhibitor AV5027.

Ivachtchenko AV, Ivanenkov YA, Mitkin OD, Yamanushkin PM, Bichko VV, Leneva IA, Borisova OV.

Antiviral Res. 2013 Dec;100(3):698-708.

PMID:
24416774
7.

Antagonists of 5-HT₆ receptors. Substituted 3-(phenylsulfonyl)pyrazolo[1,5-a]pyrido[3,4-e]pyrimidines and 3-(phenylsulfonyl)pyrazolo[1,5-a]pyrido[4,3-d]pyrimidines-Synthesis and 'structure-activity' relationship.

Ivachtchenko AV, Golovina ES, Kadieva MG, Kysil VM, Mitkin OD, Vorobiev AA, Okun I.

Bioorg Med Chem Lett. 2012 Jul 1;22(13):4273-80. doi: 10.1016/j.bmcl.2012.05.036. Epub 2012 May 17.

PMID:
22664127
8.

Synthesis and structure-activity relationship (SAR) of (5,7-disubstituted 3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidin-2-yl)-methylamines as potent serotonin 5-HT(6) receptor (5-HT(6)R) antagonists.

Ivachtchenko AV, Golovina ES, Kadieva MG, Kysil VM, Mitkin OD, Tkachenko SE, Okun IM.

J Med Chem. 2011 Dec 8;54(23):8161-73. doi: 10.1021/jm201079g. Epub 2011 Nov 10.

PMID:
22029285
9.

2-Substituted 5,6-dimethyl-3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidines: new series of highly potent and specific serotonin 5-HT6 receptor antagonists.

Ivachtchenko AV, Golovina ES, Kadieva MG, Koryakova AG, Mitkin OD, Tkachenko SE, Kysil VM, Okun I.

Eur J Med Chem. 2011 Apr;46(4):1189-97. doi: 10.1016/j.ejmech.2011.01.038. Epub 2011 Feb 1.

PMID:
21333408
10.

Synthesis and SAR of 3-arylsulfonyl-pyrazolo[1,5-a]pyrimidines as potent serotonin 5-HT6 receptor antagonists.

Ivachtchenko AV, Golovina ES, Kadieva MG, Kysil VM, Mitkin OD, Tkachenko SE, Okun I.

Bioorg Med Chem. 2011 Feb 15;19(4):1482-91. doi: 10.1016/j.bmc.2010.12.055. Epub 2011 Jan 5.

PMID:
21277782
11.

(3-Phenylsulfonylcycloalkano[e and d]pyrazolo[1,5-a]pyrimidin-2-yl)amines: potent and selective antagonists of the serotonin 5-HT6 receptor.

Ivachtchenko AV, Dmitriev DE, Golovina ES, Kadieva MG, Koryakova AG, Kysil VM, Mitkin OD, Okun IM, Tkachenko SE, Vorobiev AA.

J Med Chem. 2010 Jul 22;53(14):5186-96. doi: 10.1021/jm100350r.

PMID:
20560595
12.

Synthesis and biological study of 3-(phenylsulfonyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidines as potent and selective serotonin 5-HT6 receptor antagonists.

Ivachtchenko AV, Golovina ES, Kadieva MG, Koryakova AG, Kovalenko SM, Mitkin OD, Okun IM, Ravnyeyko IM, Tkachenko SE, Zaremba OV.

Bioorg Med Chem. 2010 Jul 15;18(14):5282-90. doi: 10.1016/j.bmc.2010.05.051. Epub 2010 May 24.

PMID:
20541425
13.

Solution phase parallel synthesis of substituted 3-phenylsulfonyl-[1,2,3]triazolo[1,5-a]quinazolines: selective serotonin 5-HT(6) receptor antagonists.

Ivachtchenko AV, Golovina ES, Kadieva MG, Koryakova AG, Kovalenko SM, Mitkin OD, Okun IM, Ravnyeyko IM, Tkachenko SE, Zaremba OV.

J Comb Chem. 2010 Jul 12;12(4):445-52. doi: 10.1021/cc1000049.

PMID:
20349953
14.

Synthesis of cycloalkane-annelated 3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidines and their evaluation as 5-HT6 receptor antagonists.

Ivachtchenko AV, Dmitriev DE, Golovina ES, Dubrovskaya ES, Kadieva MG, Koryakova AG, Kysil VM, Mitkin OD, Tkachenko SE, Okun IM, Vorobiov AA.

Bioorg Med Chem Lett. 2010 Apr 1;20(7):2133-6. doi: 10.1016/j.bmcl.2010.02.046. Epub 2010 Feb 14.

PMID:
20207539
15.

Synthesis and biological activity of 5-styryl and 5-phenethyl-substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles.

Ivachtchenko AV, Frolov EB, Mitkin OD, Tkachenko SE, Okun IM, Khvat AV.

Bioorg Med Chem Lett. 2010 Jan 1;20(1):78-82. doi: 10.1016/j.bmcl.2009.11.037. Epub 2009 Nov 14.

PMID:
19945877
16.

8-Sulfonyl-substituted tetrahydro-1H-pyrido[4,3-b]indoles as 5-HT6 receptor antagonists.

Ivachtchenko AV, Mitkin OD, Tkachenko SE, Okun IM, Kysil VM.

Eur J Med Chem. 2010 Feb;45(2):782-9. doi: 10.1016/j.ejmech.2009.10.035. Epub 2009 Oct 31.

PMID:
19939513
17.

Synthesis and biological evaluation of novel 5,8-disubstituted-2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b] indoles as 5-HT(6) and H(1) receptors antagonists.

Ivachtchenko AV, Frolov EB, Mitkin OD, Kysil VM, Khvat AV, Tkachenko SE.

Arch Pharm (Weinheim). 2009 Dec;342(12):740-7. doi: 10.1002/ardp.200900056.

PMID:
19921682
18.

Synthesis and biological evaluation of novel gamma-carboline analogues of Dimebon as potent 5-HT6 receptor antagonists.

Ivachtchenko AV, Frolov EB, Mitkin OD, Kysil VM, Khvat AV, Okun IM, Tkachenko SE.

Bioorg Med Chem Lett. 2009 Jun 15;19(12):3183-7. doi: 10.1016/j.bmcl.2009.04.128. Epub 2009 May 3.

PMID:
19443217
19.
20.

Photoactive barbiturate receptors: an ultimate lock-and-key system in which the key unlocks the lock.

Lakkakula S, Mitkin OD, Valiulin RA, Kutateladze AG.

Org Lett. 2007 Mar 15;9(6):1077-9. Epub 2007 Feb 10.

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