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Items: 1 to 20 of 274

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1.

Design, synthesis, and biological evaluation of heterotetracyclic quinolinone derivatives as anticancer agents targeting topoisomerases.

Lee JF, Chang TY, Liu ZF, Lee NZ, Yeh YH, Chen YS, Chen TC, Chou HS, Li TK, Lee SB, Lin MH.

Eur J Med Chem. 2020 Jan 30;190:112074. doi: 10.1016/j.ejmech.2020.112074. [Epub ahead of print]

PMID:
32045788
2.

Design, synthesis and biological evaluation of naphthalenebenzimidizole platinum (II) complexes as potential antitumor agents.

Liang GB, Yu YC, Wei JH, Kuang WB, Chen ZF, Zhang Y.

Eur J Med Chem. 2020 Feb 15;188:112033. doi: 10.1016/j.ejmech.2019.112033. Epub 2020 Jan 2.

PMID:
31923857
3.

Design, molecular modeling and anticancer evaluation of thieno[2,3-d]pyrimidine derivatives as inhibitors of topoisomerase II.

El-Metwally SA, Khalil AK, El-Sayed WM.

Bioorg Chem. 2020 Jan;94:103492. doi: 10.1016/j.bioorg.2019.103492. Epub 2019 Dec 4.

PMID:
31864673
4.

Formulation of injectable glycyrrhizic acid-hydroxycamptothecin micelles as new generation of DNA topoisomerase I inhibitor for enhanced antitumor activity.

Cai J, Luo S, Lv X, Deng Y, Huang H, Zhao B, Zhang Q, Li G.

Int J Pharm. 2019 Nov 25;571:118693. doi: 10.1016/j.ijpharm.2019.118693. Epub 2019 Sep 13.

PMID:
31525442
5.

IFN-γ restores the impaired function of RNase L and induces mitochondria-mediated apoptosis in lung cancer.

Yin H, Jiang Z, Wang S, Zhang P.

Cell Death Dis. 2019 Sep 9;10(9):642. doi: 10.1038/s41419-019-1902-9.

6.

Anticancer and biological properties of a Zn-2,6-diacetylpyridine bis(thiosemicarbazone) complex.

Yu P, Deng J, Cai J, Zhang Z, Zhang J, Hamid Khan M, Liang H, Yang F.

Metallomics. 2019 Aug 1;11(8):1372-1386. doi: 10.1039/c9mt00124g. Epub 2019 Jul 3.

PMID:
31267119
7.

Expressions of Topo IIα and Ki67 in breast cancer and its clinicopathologic features and prognosis.

Sun G, Wang S, Wang Y.

Pak J Med Sci. 2019;35(3):715-720. doi: 10.12669/pjms.35.3.81.

8.

Transcriptional supercoiling boosts topoisomerase II-mediated knotting of intracellular DNA.

Valdés A, Coronel L, Martínez-García B, Segura J, Dyson S, Díaz-Ingelmo O, Micheletti C, Roca J.

Nucleic Acids Res. 2019 Jul 26;47(13):6946-6955. doi: 10.1093/nar/gkz491.

9.

Molecular characterization and expression of α-gliadin genes from wheat cultivar Dacke in Bg 250 rice variety.

Kajendran K, Chandrasekharan NV, Hettiarachchi CM, Sulochana Wijesundera WS.

GM Crops Food. 2019;10(2):102-114. doi: 10.1080/21645698.2019.1622990. Epub 2019 May 29.

PMID:
31142188
10.

Design, synthesis, and docking study of new quinoline derivatives as antitumor agents.

Nasr EE, Mostafa AS, El-Sayed MAA, Massoud MAM.

Arch Pharm (Weinheim). 2019 Jul;352(7):e1800355. doi: 10.1002/ardp.201800355. Epub 2019 May 13.

PMID:
31081954
11.

Gender-specific correlates of perceived life stress: a population-based study, Montreal, Canada, 2012.

Meshefedjian GA, Fournier M, Blanchard D, Frigault LR.

Can J Public Health. 2019 Oct;110(5):563-574. doi: 10.17269/s41997-019-00205-4. Epub 2019 Apr 8.

PMID:
30963504
12.

Cryptolepine and aromathecin based mimics as potent G-quadruplex-binding, DNA-cleavage and anticancer agents: Design, synthesis and DNA targeting-induced apoptosis.

Yuan JM, Wei K, Zhang GH, Chen NY, Wei XW, Pan CX, Mo DL, Su GF.

Eur J Med Chem. 2019 May 1;169:144-158. doi: 10.1016/j.ejmech.2019.02.072. Epub 2019 Mar 4.

PMID:
30875505
13.

Identification of 3-(benzazol-2-yl)quinoxaline derivatives as potent anticancer compounds: Privileged structure-based design, synthesis, and bioactive evaluation in vitro and in vivo.

Liu QQ, Lu K, Zhu HM, Kong SL, Yuan JM, Zhang GH, Chen NY, Gu CX, Pan CX, Mo DL, Su GF.

Eur J Med Chem. 2019 Mar 1;165:293-308. doi: 10.1016/j.ejmech.2019.01.004. Epub 2019 Jan 11.

PMID:
30685528
14.

Potential new biomarkers for endometrial cancer.

Townsend MH, Ence ZE, Felsted AM, Parker AC, Piccolo SR, Robison RA, O'Neill KL.

Cancer Cell Int. 2019 Jan 21;19:19. doi: 10.1186/s12935-019-0731-3. eCollection 2019.

15.

Phytochemical naphtho[1,2-b] furan-4,5‑dione induced topoisomerase II-mediated DNA damage response in human non-small-cell lung cancer.

Chien CM, Yang JC, Wu PH, Wu CY, Chen GY, Wu YC, Chou CK, Tseng CH, Chen YL, Wang LF, Chiu CC.

Phytomedicine. 2019 Feb 15;54:109-119. doi: 10.1016/j.phymed.2018.06.025. Epub 2018 Jun 28.

PMID:
30668360
16.

Towards an understanding of C9orf82 protein/CAAP1 function.

Aslam MA, Alemdehy MF, Pritchard CEJ, Song JY, Muhaimin FI, Wijdeven RH, Huijbers IJ, Neefjes J, Jacobs H.

PLoS One. 2019 Jan 10;14(1):e0210526. doi: 10.1371/journal.pone.0210526. eCollection 2019.

17.

Synthesis, characterization, DNA binding, topoisomerase I inhibition and antiproliferation activities of three new functionalized terpyridine platinum(II) complexes.

Chai K, Kuang W, Lan Z, Zhang L, Jiang Y, Han T, Niu J, Wang J, Duan X.

J Inorg Biochem. 2019 Mar;192:17-24. doi: 10.1016/j.jinorgbio.2018.12.003. Epub 2018 Dec 7.

PMID:
30554070
18.

Increased Expression of c-Met is Associated with Chemotherapy-Resistant Breast Cancer and Poor Clinical Outcome.

Jia L, Yang X, Tian W, Guo S, Huang W, Zhao W.

Med Sci Monit. 2018 Nov 16;24:8239-8249. doi: 10.12659/MSM.913514.

19.

Multi-stimuli-responsiveness of a novel polydiacetylene-based supramolecular gel.

Xu Y, Fu S, Liu F, Yu H, Gao J.

Soft Matter. 2018 Oct 10;14(39):8044-8050. doi: 10.1039/c8sm01515e.

PMID:
30255918
20.

DNA Topoisomerase IB as a Potential Ionizing Radiation Exposure and Dose Biomarker.

Daudee R, Gonen R, German U, Orion I, Alfassi ZB, Priel E.

Radiat Res. 2018 Jun;189(6):652-660. doi: 10.1667/RR14859.1. Epub 2018 Apr 10.

PMID:
29633912

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