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Items: 1 to 20 of 47


Effects of insulin signaling on mouse taste cell proliferation.

Takai S, Watanabe Y, Sanematsu K, Yoshida R, Margolskee RF, Jiang P, Atsuta I, Koyano K, Ninomiya Y, Shigemura N.

PLoS One. 2019 Nov 12;14(11):e0225190. doi: 10.1371/journal.pone.0225190. eCollection 2019.


Expression of Renin-Angiotensin System Components in the Taste Organ of Mice.

Shigemura N, Takai S, Hirose F, Yoshida R, Sanematsu K, Ninomiya Y.

Nutrients. 2019 Sep 19;11(9). pii: E2251. doi: 10.3390/nu11092251.


Structural architecture of a dimeric class C GPCR based on co-trafficking of sweet taste receptor subunits.

Park J, Selvam B, Sanematsu K, Shigemura N, Shukla D, Procko E.

J Biol Chem. 2019 Mar 29;294(13):4759-4774. doi: 10.1074/jbc.RA118.006173. Epub 2019 Feb 5.


Diurnal Variation of Sweet Taste Recognition Thresholds Is Absent in Overweight and Obese Humans.

Sanematsu K, Nakamura Y, Nomura M, Shigemura N, Ninomiya Y.

Nutrients. 2018 Mar 2;10(3). pii: E297. doi: 10.3390/nu10030297.


The Role of Cholecystokinin in Peripheral Taste Signaling in Mice.

Yoshida R, Shin M, Yasumatsu K, Takai S, Inoue M, Shigemura N, Takiguchi S, Nakamura S, Ninomiya Y.

Front Physiol. 2017 Oct 31;8:866. doi: 10.3389/fphys.2017.00866. eCollection 2017.


Bitter Taste Responses of Gustducin-positive Taste Cells in Mouse Fungiform and Circumvallate Papillae.

Yoshida R, Takai S, Sanematsu K, Margolskee RF, Shigemura N, Ninomiya Y.

Neuroscience. 2018 Jan 15;369:29-39. doi: 10.1016/j.neuroscience.2017.10.047. Epub 2017 Nov 4.


Leptin suppresses sweet taste responses of enteroendocrine STC-1 cells.

Jyotaki M, Sanematsu K, Shigemura N, Yoshida R, Ninomiya Y.

Neuroscience. 2016 Sep 22;332:76-87. doi: 10.1016/j.neuroscience.2016.06.036. Epub 2016 Jun 25.


Taste cell-expressed α-glucosidase enzymes contribute to gustatory responses to disaccharides.

Sukumaran SK, Yee KK, Iwata S, Kotha R, Quezada-Calvillo R, Nichols BL, Mohan S, Pinto BM, Shigemura N, Ninomiya Y, Margolskee RF.

Proc Natl Acad Sci U S A. 2016 May 24;113(21):6035-40. doi: 10.1073/pnas.1520843113. Epub 2016 May 9.


Intracellular acidification is required for full activation of the sweet taste receptor by miraculin.

Sanematsu K, Kitagawa M, Yoshida R, Nirasawa S, Shigemura N, Ninomiya Y.

Sci Rep. 2016 Mar 10;6:22807. doi: 10.1038/srep22807.


Recent Advances in Molecular Mechanisms of Taste Signaling and Modifying.

Shigemura N, Ninomiya Y.

Int Rev Cell Mol Biol. 2016;323:71-106. doi: 10.1016/bs.ircmb.2015.12.004. Epub 2016 Feb 10. Review.


Leptin Suppresses Mouse Taste Cell Responses to Sweet Compounds.

Yoshida R, Noguchi K, Shigemura N, Jyotaki M, Takahashi I, Margolskee RF, Ninomiya Y.

Diabetes. 2015 Nov;64(11):3751-62. doi: 10.2337/db14-1462. Epub 2015 Jun 26.


Modulation of sweet taste sensitivities by endogenous leptin and endocannabinoids in mice.

Niki M, Jyotaki M, Yoshida R, Yasumatsu K, Shigemura N, DiPatrizio NV, Piomelli D, Ninomiya Y.

J Physiol. 2015 Jun 1;593(11):2527-45. doi: 10.1113/JP270295. Epub 2015 Apr 16.


Glucagon-like peptide-1 is specifically involved in sweet taste transmission.

Takai S, Yasumatsu K, Inoue M, Iwata S, Yoshida R, Shigemura N, Yanagawa Y, Drucker DJ, Margolskee RF, Ninomiya Y.

FASEB J. 2015 Jun;29(6):2268-80. doi: 10.1096/fj.14-265355. Epub 2015 Feb 12.


Structure, function, and signaling of taste G-protein-coupled receptors.

Sanematsu K, Yoshida R, Shigemura N, Ninomiya Y.

Curr Pharm Biotechnol. 2014;15(10):951-61. Review.


Molecular mechanisms for sweet-suppressing effect of gymnemic acids.

Sanematsu K, Kusakabe Y, Shigemura N, Hirokawa T, Nakamura S, Imoto T, Ninomiya Y.

J Biol Chem. 2014 Sep 12;289(37):25711-20. doi: 10.1074/jbc.M114.560409. Epub 2014 Jul 23.


Angiotensin II modulates salty and sweet taste sensitivities.

Shigemura N, Iwata S, Yasumatsu K, Ohkuri T, Horio N, Sanematsu K, Yoshida R, Margolskee RF, Ninomiya Y.

J Neurosci. 2013 Apr 10;33(15):6267-77. doi: 10.1523/JNEUROSCI.5599-12.2013.


Modulation of sweet responses of taste receptor cells.

Yoshida R, Niki M, Jyotaki M, Sanematsu K, Shigemura N, Ninomiya Y.

Semin Cell Dev Biol. 2013 Mar;24(3):226-31. doi: 10.1016/j.semcdb.2012.08.004. Epub 2012 Aug 25. Review.


Taste preference for fatty acids is mediated by GPR40 and GPR120.

Cartoni C, Yasumatsu K, Ohkuri T, Shigemura N, Yoshida R, Godinot N, le Coutre J, Ninomiya Y, Damak S.

J Neurosci. 2010 Jun 23;30(25):8376-82. doi: 10.1523/JNEUROSCI.0496-10.2010.


Modulation of sweet taste sensitivity by orexigenic and anorexigenic factors.

Jyotaki M, Shigemura N, Ninomiya Y.

Endocr J. 2010;57(6):467-75. Epub 2010 Apr 23. Review.


New frontiers in gut nutrient sensor research: nutrient sensors in the gastrointestinal tract: modulation of sweet taste sensitivity by leptin.

Horio N, Jyotaki M, Yoshida R, Sanematsu K, Shigemura N, Ninomiya Y.

J Pharmacol Sci. 2010;112(1):8-12. Review.

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