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Antioxidants (Basel). 2019 Apr 18;8(4). pii: E106. doi: 10.3390/antiox8040106.

The Role of Isothiocyanates as Cancer Chemo-Preventive, Chemo-Therapeutic and Anti-Melanoma Agents.

Author information

1
Department of Applied Sciences, Northumbria University, Newcastle Upon Tyne NE1 8ST, UK. melina.mitsiogianni@northumbria.ac.uk.
2
Department of Applied Sciences, Northumbria University, Newcastle Upon Tyne NE1 8ST, UK. georgios.koutsidis@northumbria.ac.uk.
3
Department of Food and Nutritional Sciences, University of Reading, Reading RG6 6AP, UK. nikos.mavroudis@reading.ac.uk.
4
Laboratory of Pharmacology, Unit of Clinical Pharmacology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece. dtrafal@med.uoa.gr.
5
Second Department of Surgery, Democritus University of Thrace, 68100 Alexandroupolis, Greece. smpotait@med.duth.gr.
6
Redox Biology Centre, University of Nebraska-Lincoln, Lincoln, NE 68588, USA. rodrigo.franco@unl.edu.
7
School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA. rodrigo.franco@unl.edu.
8
Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, 11635 Athens, Greece. vzub@eie.gr.
9
The Watrercress Company / The Wasabi Company, Waddock, Dorchester, Dorset DT2 8QY, UK. tom.amery@thewatercresscompany.com.
10
Department of Molecular Biology and Genetics, Democritus University of Thrace, 68100 Alexandroupolis, Greece. agalanis@mbg.duth.gr.
11
Department of Molecular Biology and Genetics, Democritus University of Thrace, 68100 Alexandroupolis, Greece. apappa@mbg.duth.gr.
12
Department of Applied Sciences, Northumbria University, Newcastle Upon Tyne NE1 8ST, UK. m.panagiotidis@northumbria.ac.uk.

Abstract

Many studies have shown evidence in support of the beneficial effects of phytochemicals in preventing chronic diseases, including cancer. Among such phytochemicals, sulphur-containing compounds (e.g., isothiocyanates (ITCs)) have raised scientific interest by exerting unique chemo-preventive properties against cancer pathogenesis. ITCs are the major biologically active compounds capable of mediating the anticancer effect of cruciferous vegetables. Recently, many studies have shown that a higher intake of cruciferous vegetables is associated with reduced risk of developing various forms of cancers primarily due to a plurality of effects, including (i) metabolic activation and detoxification, (ii) inflammation, (iii) angiogenesis, (iv) metastasis and (v) regulation of the epigenetic machinery. In the context of human malignant melanoma, a number of studies suggest that ITCs can cause cell cycle growth arrest and also induce apoptosis in human malignant melanoma cells. On such basis, ITCs could serve as promising chemo-therapeutic agents that could be used in the clinical setting to potentiate the efficacy of existing therapies.

KEYWORDS:

cell cycle; chemo-therapy; cruciferous vegetables; glucosinolates; growth arrest; isothiocyanates; malignant melanoma; skin cancer

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