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Sensors (Basel). 2014 Sep 12;14(9):17008-36. doi: 10.3390/s140917008.

Various on-chip sensors with microfluidics for biological applications.

Author information

1
Department of Electrical Engineering, University at Buffalo, State University of New York (SUNY at Buffalo), Buffalo, NY 14260, USA. hlee24@buffalo.edu.
2
Department of Electrical Engineering, University at Buffalo, State University of New York (SUNY at Buffalo), Buffalo, NY 14260, USA. linfengx@buffalo.edu.
3
Department of Electrical Engineering, University at Buffalo, State University of New York (SUNY at Buffalo), Buffalo, NY 14260, USA. dominkoh@buffalo.edu.
4
Department of Electrical Engineering, University at Buffalo, State University of New York (SUNY at Buffalo), Buffalo, NY 14260, USA. nikhilan@buffalo.edu.
5
Department of Electrical Engineering, University at Buffalo, State University of New York (SUNY at Buffalo), Buffalo, NY 14260, USA. kwangoh@buffalo.edu.

Abstract

In this paper, we review recent advances in on-chip sensors integrated with microfluidics for biological applications. Since the 1990s, much research has concentrated on developing a sensing system using optical phenomena such as surface plasmon resonance (SPR) and surface-enhanced Raman scattering (SERS) to improve the sensitivity of the device. The sensing performance can be significantly enhanced with the use of microfluidic chips to provide effective liquid manipulation and greater flexibility. We describe an optical image sensor with a simpler platform for better performance over a larger field of view (FOV) and greater depth of field (DOF). As a new trend, we review consumer electronics such as smart phones, tablets, Google glasses, etc. which are being incorporated in point-of-care (POC) testing systems. In addition, we discuss in detail the current optical sensing system integrated with a microfluidic chip.

PMID:
25222033
PMCID:
PMC4208211
DOI:
10.3390/s140917008
[Indexed for MEDLINE]
Free PMC Article
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