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Items: 1 to 20 of 24


The Peptide PnPP-19, a Spider Toxin Derivative, Activates μ-Opioid Receptors and Modulates Calcium Channels.

Freitas ACN, Peigneur S, Macedo FHP, Menezes-Filho JE, Millns P, Medeiros LF, Arruda MA, Cruz J, Holliday ND, Tytgat J, Hathway G, de Lima ME.

Toxins (Basel). 2018 Jan 15;10(1). pii: E43. doi: 10.3390/toxins10010043.


Identification of a Cyanine-Dye Labeled Peptidic Ligand for Y1R and Y4R, Based upon the Neuropeptide Y C-Terminal Analogue, BVD-15.

Liu M, Richardson RR, Mountford SJ, Zhang L, Tempone MH, Herzog H, Holliday ND, Thompson PE.

Bioconjug Chem. 2016 Sep 21;27(9):2166-75. doi: 10.1021/acs.bioconjchem.6b00376. Epub 2016 Aug 25.


Optically Pure, Structural, and Fluorescent Analogues of a Dimeric Y4 Receptor Agonist Derived by an Olefin Metathesis Approach.

Liu M, Mountford SJ, Richardson RR, Groenen M, Holliday ND, Thompson PE.

J Med Chem. 2016 Jul 14;59(13):6059-69. doi: 10.1021/acs.jmedchem.6b00310. Epub 2016 Jun 28.


Unravelling intrinsic efficacy and ligand bias at G protein coupled receptors: A practical guide to assessing functional data.

Stott LA, Hall DA, Holliday ND.

Biochem Pharmacol. 2016 Feb 1;101:1-12. doi: 10.1016/j.bcp.2015.10.011. Epub 2015 Oct 23. Review.


Plasma membrane dynamics and tetrameric organisation of ABCG2 transporters in mammalian cells revealed by single particle imaging techniques.

Wong K, Briddon SJ, Holliday ND, Kerr ID.

Biochim Biophys Acta. 2016 Jan;1863(1):19-29. doi: 10.1016/j.bbamcr.2015.10.002. Epub 2015 Oct 8.


Biased Gs versus Gq proteins and β-arrestin signaling in the NK1 receptor determined by interactions in the water hydrogen bond network.

Valentin-Hansen L, Frimurer TM, Mokrosinski J, Holliday ND, Schwartz TW.

J Biol Chem. 2015 Oct 2;290(40):24495-508. doi: 10.1074/jbc.M115.641944. Epub 2015 Aug 12.


A G protein-coupled receptor dimer imaging assay reveals selectively modified pharmacology of neuropeptide Y Y1/Y5 receptor heterodimers.

Kilpatrick LE, Humphrys LJ, Holliday ND.

Mol Pharmacol. 2015 Apr;87(4):718-32. doi: 10.1124/mol.114.095356. Epub 2015 Jan 30.


Deciphering the complex three-way interaction between the non-integrin laminin receptor, galectin-3 and Neisseria meningitidis.

Alqahtani F, Mahdavi J, Wheldon LM, Vassey M, Pirinccioglu N, Royer PJ, Qarani SM, Morroll S, Stoof J, Holliday ND, Teo SY, Oldfield NJ, Wooldridge KG, Ala'Aldeen DA.

Open Biol. 2014 Oct;4(10). pii: 140053. doi: 10.1098/rsob.140053.


Synthetic routes to the Neuropeptide Y Y1 receptor antagonist 1229U91 and related analogues for SAR studies and cell-based imaging.

Mountford SJ, Liu M, Zhang L, Groenen M, Herzog H, Holliday ND, Thompson PE.

Org Biomol Chem. 2014 May 28;12(20):3271-81. doi: 10.1039/c4ob00176a. Epub 2014 Apr 14.


The arginine of the DRY motif in transmembrane segment III functions as a balancing micro-switch in the activation of the β2-adrenergic receptor.

Valentin-Hansen L, Groenen M, Nygaard R, Frimurer TM, Holliday ND, Schwartz TW.

J Biol Chem. 2012 Sep 14;287(38):31973-82. doi: 10.1074/jbc.M112.348565. Epub 2012 Jul 26.


Dissecting the pharmacology of G protein-coupled receptor signaling complexes using bimolecular fluorescence complementation.

Kilpatrick LE, Holliday ND.

Methods Mol Biol. 2012;897:109-38. doi: 10.1007/978-1-61779-909-9_6.


Differential signaling by splice variants of the human free fatty acid receptor GPR120.

Watson SJ, Brown AJ, Holliday ND.

Mol Pharmacol. 2012 May;81(5):631-42. doi: 10.1124/mol.111.077388. Epub 2012 Jan 26.


Dimerization of ABCG2 analysed by bimolecular fluorescence complementation.

Haider AJ, Briggs D, Self TJ, Chilvers HL, Holliday ND, Kerr ID.

PLoS One. 2011;6(10):e25818. doi: 10.1371/journal.pone.0025818. Epub 2011 Oct 3.


Dimer formation and conformational flexibility ensure cytoplasmic stability and nuclear accumulation of Elk-1.

Evans EL, Saxton J, Shelton SJ, Begitt A, Holliday ND, Hipskind RA, Shaw PE.

Nucleic Acids Res. 2011 Aug;39(15):6390-402. doi: 10.1093/nar/gkr266. Epub 2011 May 4.


Unique interaction pattern for a functionally biased ghrelin receptor agonist.

Sivertsen B, Lang M, Frimurer TM, Holliday ND, Bach A, Els S, Engelstoft MS, Petersen PS, Madsen AN, Schwartz TW, Beck-Sickinger AG, Holst B.

J Biol Chem. 2011 Jun 10;286(23):20845-60. doi: 10.1074/jbc.M110.173237. Epub 2011 Mar 14.


Drug discovery opportunities and challenges at g protein coupled receptors for long chain free Fatty acids.

Holliday ND, Watson SJ, Brown AJ.

Front Endocrinol (Lausanne). 2012 Jan 3;2:112. doi: 10.3389/fendo.2011.00112. eCollection 2011.


Bimolecular fluorescence complementation: lighting up seven transmembrane domain receptor signalling networks.

Rose RH, Briddon SJ, Holliday ND.

Br J Pharmacol. 2010 Feb;159(4):738-50. doi: 10.1111/j.1476-5381.2009.00480.x. Epub 2009 Dec 10. Review.


Characterization of G-protein coupled receptor kinase interaction with the neurokinin-1 receptor using bioluminescence resonance energy transfer.

Jorgensen R, Holliday ND, Hansen JL, Vrecl M, Heding A, Schwartz TW, Elling CE.

Mol Pharmacol. 2008 Feb;73(2):349-58. Epub 2007 Nov 6.


Importance of constitutive activity and arrestin-independent mechanisms for intracellular trafficking of the ghrelin receptor.

Holliday ND, Holst B, Rodionova EA, Schwartz TW, Cox HM.

Mol Endocrinol. 2007 Dec;21(12):3100-12. Epub 2007 Aug 23.


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