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Items: 10

1.

In Human and Mouse Spino-Cerebellar Tissue, Ataxin-2 Expansion Affects Ceramide-Sphingomyelin Metabolism.

Sen NE, Arsovic A, Meierhofer D, Brodesser S, Oberschmidt C, Canet-Pons J, Kaya ZE, Halbach MV, Gispert S, Sandhoff K, Auburger G.

Int J Mol Sci. 2019 Nov 21;20(23). pii: E5854. doi: 10.3390/ijms20235854.

2.

Generation of an Atxn2-CAG100 knock-in mouse reveals N-acetylaspartate production deficit due to early Nat8l dysregulation.

Sen NE, Canet-Pons J, Halbach MV, Arsovic A, Pilatus U, Chae WH, Kaya ZE, Seidel K, Rollmann E, Mittelbronn M, Meierhofer D, De Zeeuw CI, Bosman LWJ, Gispert S, Auburger G.

Neurobiol Dis. 2019 Dec;132:104559. doi: 10.1016/j.nbd.2019.104559. Epub 2019 Jul 31.

3.

SerThr-PhosphoProteome of Brain from Aged PINK1-KO+A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes.

Auburger G, Gispert S, Torres-Odio S, Jendrach M, Brehm N, Canet-Pons J, Key J, Sen NE.

Int J Mol Sci. 2019 Jul 4;20(13). pii: E3284. doi: 10.3390/ijms20133284.

4.

Elevated Global DNA Methylation Is Not Exclusive to Amyotrophic Lateral Sclerosis and Is Also Observed in Spinocerebellar Ataxia Types 1 and 2.

Hamzeiy H, Savaş D, Tunca C, Şen NE, Gündoğdu Eken A, Şahbaz I, Calini D, Tiloca C, Ticozzi N, Ratti A, Silani V, Başak AN.

Neurodegener Dis. 2018;18(1):38-48. doi: 10.1159/000486201. Epub 2018 Feb 9.

PMID:
29428949
5.

Efficient Prevention of Neurodegenerative Diseases by Depletion of Starvation Response Factor Ataxin-2.

Auburger G, Sen NE, Meierhofer D, Başak AN, Gitler AD.

Trends Neurosci. 2017 Aug;40(8):507-516. doi: 10.1016/j.tins.2017.06.004. Epub 2017 Jul 3. Review.

PMID:
28684172
6.

Quantitative Global Proteomics of Yeast PBP1 Deletion Mutants and Their Stress Responses Identifies Glucose Metabolism, Mitochondrial, and Stress Granule Changes.

Seidel G, Meierhofer D, Şen NE, Guenther A, Krobitsch S, Auburger G.

J Proteome Res. 2017 Feb 3;16(2):504-515. doi: 10.1021/acs.jproteome.6b00647. Epub 2016 Dec 22.

PMID:
27966978
7.

Search for SCA2 blood RNA biomarkers highlights Ataxin-2 as strong modifier of the mitochondrial factor PINK1 levels.

Sen NE, Drost J, Gispert S, Torres-Odio S, Damrath E, Klinkenberg M, Hamzeiy H, Akdal G, Güllüoğlu H, Başak AN, Auburger G.

Neurobiol Dis. 2016 Dec;96:115-126. doi: 10.1016/j.nbd.2016.09.002. Epub 2016 Sep 3.

PMID:
27597528
8.

Ataxin-2 (Atxn2)-Knock-Out Mice Show Branched Chain Amino Acids and Fatty Acids Pathway Alterations.

Meierhofer D, Halbach M, Şen NE, Gispert S, Auburger G.

Mol Cell Proteomics. 2016 May;15(5):1728-39. doi: 10.1074/mcp.M115.056770. Epub 2016 Feb 5.

9.

Both ubiquitin ligases FBXW8 and PARK2 are sequestrated into insolubility by ATXN2 PolyQ expansions, but only FBXW8 expression is dysregulated.

Halbach MV, Stehning T, Damrath E, Jendrach M, Şen NE, Başak AN, Auburger G.

PLoS One. 2015 Mar 19;10(3):e0121089. doi: 10.1371/journal.pone.0121089. eCollection 2015.

10.

The distinct genetic pattern of ALS in Turkey and novel mutations.

Özoğuz A, Uyan Ö, Birdal G, Iskender C, Kartal E, Lahut S, Ömür Ö, Agim ZS, Eken AG, Sen NE, Kavak P, Saygı C, Sapp PC, Keagle P, Parman Y, Tan E, Koç F, Deymeer F, Oflazer P, Hanağası H, Gürvit H, Bilgiç B, Durmuş H, Ertaş M, Kotan D, Akalın MA, Güllüoğlu H, Zarifoğlu M, Aysal F, Döşoğlu N, Bilguvar K, Günel M, Keskin Ö, Akgün T, Özçelik H, Landers JE, Brown RH, Başak AN.

Neurobiol Aging. 2015 Apr;36(4):1764.e9-1764.e18. doi: 10.1016/j.neurobiolaging.2014.12.032. Epub 2015 Jan 10.

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