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Org Biomol Chem. 2019 May 15;17(19):4850-4855. doi: 10.1039/c9ob00701f.

Synthesis of pyrazolylvinyl ketones from furan derivatives.

Author information

1
Department of Chemistry and Pharmacy, Institute of Medicinal Chemistry, University of Erlangen-Nuremberg, Nikolaus-Fiebiger-Str. 10, Erlangen, 91058, Germany. olga@serdyuk.de.

Abstract

A new protocol for the synthesis of pyrazol-5-ylvinyl ketones, e.g. pyrazole-chalcones, employing furfuryl ketones as a triketone equivalent, has been developed. The reaction occurs under mild conditions and does not require the use of expensive materials. Other important benefits include the simplicity and atom efficiency of this approach.

PMID:
31037280
DOI:
10.1039/c9ob00701f

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