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Medicina (Kaunas). 2018 May 28;54(3). pii: E37. doi: 10.3390/medicina54030037.

The Clinical Importance of Cystatin C and Hepatic Artery Resistive Index in Liver Cirrhosis.

Author information

1
Clinic for Gastroenterology and Hepatology, Clinical Center of Serbia, School of Medicine-University of Belgrade, 11000 Belgrade, Serbia. drstulic@gmail.com.
2
Clinic for Gastroenterology and Hepatology, Clinical Center of Serbia, School of Medicine-University of Belgrade, 11000 Belgrade, Serbia. djordjeculafic@sbb.rs.
3
Institute of Medical Biochemistry, Clinical Center of Serbia, 11000 Belgrade, Serbia. radmilaobrenovic7@gmail.com.
4
Clinic for Gastroenterology and Hepatology, Clinical Center of Serbia, School of Medicine-University of Belgrade, 11000 Belgrade, Serbia. goran.jankovic@kcs.ac.rs.
5
Clinic for Gastroenterology and Hepatology, Clinical Center of Serbia, School of Medicine-University of Belgrade, 11000 Belgrade, Serbia. tamara.alempijevic@med.bg.ac.rs.
6
Clinic for Gastroenterology and Hepatology, Clinical Center of Serbia, School of Medicine-University of Belgrade, 11000 Belgrade, Serbia. jagodica85@gmail.com.
7
Special Hospital for Addiction Diseases "Drajzerova", 11000 Belgrade, Serbia. nakidostanic@gmail.com.
8
Department of Pharmacokinetics and Clinical Pharmacy, Faculty of Pharmacy-University of Belgrade, 11000 Belgrade, Serbia. svezmar@pharmacy.bg.ac.rs.
9
Department of Pharmacokinetics and Clinical Pharmacy, Faculty of Pharmacy-University of Belgrade, 11000 Belgrade, Serbia. milica.culafic@gmail.com.

Abstract

BACKGROUND:

Data suggest cystatin C (CysC) levels and hepatic artery resistive index (HARI) correspond to the progression of chronic liver disease. We aimed to evaluate the clinical significance of these parameters in assessment of fibrosis in patients with liver cirrhosis.

METHODS:

The cross-sectional study included 63 patients with liver cirrhosis. A control group consisted of 30 age- and gender-matched healthy persons.

RESULTS:

We confirmed significantly higher values of CysC in patients with cirrhosis compared to control group (p = 0.036). Average value of HARI in the examined group was increased (0.72 ± 0.06) and there was the statistically significant difference compared to controls (0.66 ± 0.03) (p < 0.001). We found statistically significant correlation between HARI and CysC in the study group. Analyzing the possibility of distinguishing healthy subjects from patients with fibrosis, we have found that the area under the curve is far greater in the HARI index than CysC. Comparison of CysC among Child⁻Pugh stages and correlation with a model for end-stage liver disease (MELD) score showed statistically significant results.

CONCLUSION:

We confirmed HARI is a more accurate parameter than CysC in discriminating healthy subjects from patients with fibrosis, while CysC could be a better indicator of the stage of liver cirrhosis.

KEYWORDS:

Cystatin C; hepatic artery resistive index; liver cirrhosis

PMID:
30344268
PMCID:
PMC6122118
DOI:
10.3390/medicina54030037
[Indexed for MEDLINE]
Free PMC Article

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