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Items: 1 to 20 of 65

1.

Deep insights into the response of human cervical carcinoma cells to a new cyano enone-bearing triterpenoid soloxolone methyl: a transcriptome analysis.

Markov AV, Kel AE, Salomatina OV, Salakhutdinov NF, Zenkova MA, Logashenko EB.

Oncotarget. 2019 Sep 3;10(51):5267-5297. doi: 10.18632/oncotarget.27085. eCollection 2019 Sep 3.

PMID:
31523389
2.

A Novel Small Molecule Supports the Survival of Cultured Dopamine Neurons and May Restore the Dopaminergic Innervation of the Brain in the MPTP Mouse Model of Parkinson's Disease.

Ardashov OV, Pavlova AV, Mahato AK, Sidorova Y, Morozova EA, Korchagina DV, Salnikov GE, Genaev AM, Patrusheva OS, Li-Zhulanov NS, Tolstikova TG, Volcho KP, Salakhutdinov NF.

ACS Chem Neurosci. 2019 Sep 11. doi: 10.1021/acschemneuro.9b00396. [Epub ahead of print]

PMID:
31464415
3.

Dehydroabietylamine Ureas and Thioureas as Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Enhance the Antitumor Effect of Temozolomide on Glioblastoma Cells.

Kovaleva K, Oleshko O, Mamontova E, Yarovaya O, Zakharova O, Zakharenko A, Kononova A, Dyrkheeva N, Cheresiz S, Pokrovsky A, Lavrik O, Salakhutdinov N.

J Nat Prod. 2019 Aug 20. doi: 10.1021/acs.jnatprod.8b01095. [Epub ahead of print]

PMID:
31430155
4.

Novel Derivatives of Deoxycholic Acid Bearing Linear Aliphatic Diamine and Aminoalcohol Moieties and their Cyclic Analogs at the C3 Position: Synthesis and Evaluation of Their In Vitro Antitumor Potential.

Markov AV, Babich VO, Popadyuk II, Salomatina OV, Logashenko EB, Salakhutdinov NF, Zenkova MA.

Molecules. 2019 Jul 21;24(14). pii: E2644. doi: 10.3390/molecules24142644.

5.

Antimicrobial Activity of Substituted Benzopentathiepin-6-amines.

Khomenko TM, Korchagina DV, Baev DS, Vassiliev PM, Volcho KP, Salakhutdinov NF.

J Antibiot (Tokyo). 2019 Aug;72(8):590-599. doi: 10.1038/s41429-019-0191-y. Epub 2019 May 22.

PMID:
31118480
6.

Single-stage synthesis of heterocyclic alkaloid-like compounds from (+)-camphoric acid and their antiviral activity.

Chernyshov VV, Yarovaya OI, Fadeev DS, Gatilov YV, Esaulkova YL, Muryleva AS, Sinegubova KO, Zarubaev VV, Salakhutdinov NF.

Mol Divers. 2019 Feb 28. doi: 10.1007/s11030-019-09932-9. [Epub ahead of print]

PMID:
30820742
7.

Synthesis of d-(+)-camphor-based N-acylhydrazones and their antiviral activity.

Kovaleva KS, Zubkov FI, Bormotov NI, Novikov RA, Dorovatovskii PV, Khrustalev VN, Gatilov YV, Zarubaev VV, Yarovaya OI, Shishkina LN, Salakhutdinov NF.

Medchemcomm. 2018 Oct 26;9(12):2072-2082. doi: 10.1039/c8md00442k. eCollection 2018 Dec 1.

PMID:
30746065
8.

Mechanism of action of an old antibiotic revisited: Role of calcium ions in protonophoric activity of usnic acid.

Antonenko YN, Khailova LS, Rokitskaya TI, Nosikova ES, Nazarov PA, Luzina OA, Salakhutdinov NF, Kotova EA.

Biochim Biophys Acta Bioenerg. 2019 Apr 1;1860(4):310-316. doi: 10.1016/j.bbabio.2019.01.005. Epub 2019 Jan 30.

PMID:
30710552
9.

Novel Inhibitors of DNA Repair Enzyme TDP1 Combining Monoterpenoid and Adamantane Fragments.

Mozhaitsev ES, Zakharenko AL, Suslov EV, Korchagina DV, Zakharova OD, Vasil'eva IA, Chepanova AA, Black E, Patel J, Chand R, Reynisson J, Leung IKH, Volcho KP, Salakhutdinov NF, Lavrik OI.

Anticancer Agents Med Chem. 2019;19(4):463-472. doi: 10.2174/1871520619666181207094243.

PMID:
30523770
10.

Synthesis and antiviral activity of camphor-based 1,3-thiazolidin-4-one and thiazole derivatives as Orthopoxvirus-reproduction inhibitors.

Sokolova AS, Yarovaya OI, Bormotov NI, Shishkina LN, Salakhutdinov NF.

Medchemcomm. 2018 Sep 19;9(10):1746-1753. doi: 10.1039/c8md00347e. eCollection 2018 Oct 1.

PMID:
30429979
11.

A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2H-chromen-4-ol Scaffold.

Li-Zhulanov NS, Zakharenko AL, Chepanova AA, Patel J, Zafar A, Volcho KP, Salakhutdinov NF, Reynisson J, Leung IKH, Lavrik OI.

Molecules. 2018 Sep 26;23(10). pii: E2468. doi: 10.3390/molecules23102468.

12.

Untargeted search and identification of metabolites of antiviral agent camphecene in rat urine by liquid chromatography and mass spectrometry and studying their distribution in organs following peroral administration of the compound.

Rogachev AD, Yarovaya OI, Fatianova AV, Lavrinenko VA, Amosov EV, Zarubaev VV, Pokrovsky AG, Salakhutdinov NF.

J Pharm Biomed Anal. 2018 Nov 30;161:383-392. doi: 10.1016/j.jpba.2018.09.003. Epub 2018 Sep 5.

PMID:
30205302
13.

Neuroregeneration in Parkinson's Disease: From Proteins to Small Molecules.

Sidorova YA, Volcho KP, Salakhutdinov NF.

Curr Neuropharmacol. 2019;17(3):268-287. doi: 10.2174/1570159X16666180905094123. Review.

14.

Selection of influenza virus resistant to the novel camphor-based antiviral camphecene results in loss of pathogenicity.

Zarubaev VV, Pushkina EA, Borisevich SS, Galochkina AV, Garshinina AV, Shtro AA, Egorova AA, Sokolova AS, Khursan SL, Yarovaya OI, Salakhutdinov NF.

Virology. 2018 Nov;524:69-77. doi: 10.1016/j.virol.2018.08.011. Epub 2018 Aug 27.

PMID:
30165308
15.

Inhibitory Effect of New Semisynthetic Usnic Acid Derivatives on Human Tyrosyl-DNA Phosphodiesterase 1.

Dyrkheeva N, Luzina O, Filimonov A, Zakharova O, Ilina E, Zakharenko A, Kuprushkin M, Nilov D, Gushchina I, Švedas V, Salakhutdinov N, Lavrik O.

Planta Med. 2019 Jan;85(2):103-111. doi: 10.1055/a-0681-7069. Epub 2018 Aug 24.

PMID:
30142660
16.

Synthesis and evaluation of aryliden- and hetarylidenfuranone derivatives of usnic acid as highly potent Tdp1 inhibitors.

Zakharova O, Luzina O, Zakharenko A, Sokolov D, Filimonov A, Dyrkheeva N, Chepanova A, Ilina E, Ilyina A, Klabenkova K, Chelobanov B, Stetsenko D, Zafar A, Eurtivong C, Reynisson J, Volcho K, Salakhutdinov N, Lavrik O.

Bioorg Med Chem. 2018 Aug 15;26(15):4470-4480. doi: 10.1016/j.bmc.2018.07.039. Epub 2018 Jul 24.

PMID:
30076000
17.

Discovery of a New Class of Inhibitors of Vaccinia Virus Based on (-)-Borneol from Abies sibirica and (+)-Camphor.

Sokolova AS, Yarovaya OI, Bormotov NI, Shishkina LN, Salakhutdinov NF.

Chem Biodivers. 2018 Sep;15(9):e1800153. doi: 10.1002/cbdv.201800153. Epub 2018 Aug 9.

PMID:
29956885
18.

Usnic acid and its derivatives for pharmaceutical use: a patent review (2000-2017).

Luzina OA, Salakhutdinov NF.

Expert Opin Ther Pat. 2018 Jun;28(6):477-491. doi: 10.1080/13543776.2018.1472239. Epub 2018 May 9. Review.

PMID:
29718734
19.

Highly potent activity of isopulegol-derived substituted octahydro-2H-chromen-4-ols against influenza A and B viruses.

Ilyina IV, Zarubaev VV, Lavrentieva IN, Shtro AA, Esaulkova IL, Korchagina DV, Borisevich SS, Volcho KP, Salakhutdinov NF.

Bioorg Med Chem Lett. 2018 Jun 15;28(11):2061-2067. doi: 10.1016/j.bmcl.2018.04.057. Epub 2018 Apr 24.

PMID:
29716780
20.

Novel Semisynthetic Derivatives of Bile Acids as Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibitors.

Salomatina OV, Popadyuk II, Zakharenko AL, Zakharova OD, Fadeev DS, Komarova NI, Reynisson J, Arabshahi HJ, Chand R, Volcho KP, Salakhutdinov NF, Lavrik OI.

Molecules. 2018 Mar 17;23(3). pii: E679. doi: 10.3390/molecules23030679.

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