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Items: 1 to 20 of 30

1.

Activation of PXR, CAR and PPARα by pyrethroid pesticides and the effect of metabolism by rat liver microsomes.

Fujino C, Watanabe Y, Sanoh S, Nakajima H, Uramaru N, Kojima H, Yoshinari K, Ohta S, Kitamura S.

Heliyon. 2019 Sep 12;5(9):e02466. doi: 10.1016/j.heliyon.2019.e02466. eCollection 2019 Sep.

2.

Comparative study of the effect of 17 parabens on PXR-, CAR- and PPARα-mediated transcriptional activation.

Fujino C, Watanabe Y, Sanoh S, Hattori S, Nakajima H, Uramaru N, Kojima H, Yoshinari K, Ohta S, Kitamura S.

Food Chem Toxicol. 2019 Nov;133:110792. doi: 10.1016/j.fct.2019.110792. Epub 2019 Aug 28.

PMID:
31472229
3.

Profiling of bisphenol A and eight its analogues on transcriptional activity via human nuclear receptors.

Kojima H, Takeuchi S, Sanoh S, Okuda K, Kitamura S, Uramaru N, Sugihara K, Yoshinari K.

Toxicology. 2019 Feb 1;413:48-55. doi: 10.1016/j.tox.2018.12.001. Epub 2018 Dec 21.

PMID:
30582956
4.

Identification of hepatic thyroid hormone-responsive genes in neonatal rats: Potential targets for thyroid hormone-disrupting chemicals.

Fujimoto N, Kitamura S, Uramaru N, Miyagawa S, Iguchi T.

Toxicol Lett. 2018 Apr;286:48-53. doi: 10.1016/j.toxlet.2018.01.005. Epub 2018 Feb 2.

PMID:
29357290
5.

Protective Effects of Tormentic Acid, a Major Component of Suspension Cultures of Eriobotrya japonica Cells, on Acetaminophen-Induced Hepatotoxicity in Mice.

Jiang WP, Huang SS, Matsuda Y, Saito H, Uramaru N, Ho HY, Wu JB, Huang GJ.

Molecules. 2017 May 18;22(5). pii: E830. doi: 10.3390/molecules22050830.

6.

One-Flask Synthesis of Pyrazolo[3,4-d]pyrimidines from 5-Aminopyrazoles and Mechanistic Study.

Yen WP, Tsai SE, Uramaru N, Takayama H, Wong FF.

Molecules. 2017 May 16;22(5). pii: E820. doi: 10.3390/molecules22050820.

7.

Construction of the Database of Rat Repeated-dose Toxicity Tests of Pesticides for the Toxicological Characterization of Hepatocyte Hypertrophy.

Masuda A, Masuda M, Kawano T, Kitsunai Y, Nakayama H, Nakajima H, Kojima H, Kitamura S, Uramaru N, Hosaka T, Sasaki T, Yoshinari K.

Yakugaku Zasshi. 2017;137(5):611-622. doi: 10.1248/yakushi.16-00259. Japanese.

8.

Altered expression of the Olr59, Ethe1, and Slc10a2 genes in the liver of F344 rats by neonatal thyroid hormone disruption.

Matsubara K, Nakamura N, Sanoh S, Ohta S, Kitamura S, Uramaru N, Miyagawa S, Iguchi T, Fujimoto N.

J Appl Toxicol. 2017 Sep;37(9):1030-1035. doi: 10.1002/jat.3452. Epub 2017 Mar 16.

PMID:
28299817
9.

Variability of Zaleplon 5-Oxidase Activity in Mice and Humans, and Inhibition by Raloxifene.

Tanoue C, Sugihara K, Tayama Y, Uramaru N, Watanabe Y, Ohta S, Kitamura S.

Drug Metab Lett. 2017;10(4):278-285. doi: 10.2174/1872312810666161227145358.

PMID:
28029084
10.

Comparative study of hydrolytic metabolism of dimethyl phthalate, dibutyl phthalate and di(2-ethylhexyl) phthalate by microsomes of various rat tissues.

Ozaki H, Sugihara K, Watanabe Y, Moriguchi K, Uramaru N, Sone T, Ohta S, Kitamura S.

Food Chem Toxicol. 2017 Feb;100:217-224. doi: 10.1016/j.fct.2016.12.019. Epub 2016 Dec 19.

PMID:
28007454
11.

Metabolism of methiocarb and carbaryl by rat and human livers and plasma, and effect on their PXR, CAR and PPARα activities.

Fujino C, Tamura Y, Tange S, Nakajima H, Sanoh S, Watanabe Y, Uramaru N, Kojima H, Yoshinari K, Ohta S, Kitamura S.

J Toxicol Sci. 2016;41(5):677-91. doi: 10.2131/jts.41.677.

12.

In vitro metabolism of methiocarb and carbaryl in rats, and its effect on their estrogenic and antiandrogenic activities.

Tange S, Fujimoto N, Uramaru N, Wong FF, Sugihara K, Ohta S, Kitamura S.

Environ Toxicol Pharmacol. 2016 Jan;41:289-97. doi: 10.1016/j.etap.2015.08.014. Epub 2015 Aug 14.

PMID:
26774076
13.

Hydrolytic metabolism of phenyl and benzyl salicylates, fragrances and flavoring agents in foods, by microsomes of rat and human tissues.

Ozaki H, Sugihara K, Tamura Y, Fujino C, Watanabe Y, Uramaru N, Sone T, Ohta S, Kitamura S.

Food Chem Toxicol. 2015 Dec;86:116-23. doi: 10.1016/j.fct.2015.08.024. Epub 2015 Aug 28.

PMID:
26321725
14.

[Basic principles of interpretation of hepatocellular hypertrophy in risk assessment in Japan].

Yoshida M, Umemura T, Kojima H, Inoue K, Takahashi M, Uramaru N, Kitamura S, Abe K, Tohkin M, Ozawa S, Yoshinari K.

Shokuhin Eiseigaku Zasshi. 2015;56(2):42-8. doi: 10.3358/shokueishi.56.42. Review. Japanese.

15.

Metabolism of UV-filter benzophenone-3 by rat and human liver microsomes and its effect on endocrine-disrupting activity.

Watanabe Y, Kojima H, Takeuchi S, Uramaru N, Sanoh S, Sugihara K, Kitamura S, Ohta S.

Toxicol Appl Pharmacol. 2015 Jan 15;282(2):119-28. doi: 10.1016/j.taap.2014.12.002. Epub 2014 Dec 17.

PMID:
25528284
16.

In vitro metabolism of cis- and trans-permethrin by rat liver microsomes, and its effect on estrogenic and anti-androgenic activities.

Tange S, Fujimoto N, Uramaru N, Sugihara K, Ohta S, Kitamura S.

Environ Toxicol Pharmacol. 2014 May;37(3):996-1005. doi: 10.1016/j.etap.2014.03.009. Epub 2014 Mar 21.

PMID:
24731973
17.
18.

Transesterification of a series of 12 parabens by liver and small-intestinal microsomes of rats and humans.

Fujino C, Watanabe Y, Uramaru N, Kitamura S.

Food Chem Toxicol. 2014 Feb;64:361-8. doi: 10.1016/j.fct.2013.12.013. Epub 2013 Dec 17.

PMID:
24355169
19.

Structure-activity relationships of 44 halogenated compounds for iodotyrosine deiodinase-inhibitory activity.

Shimizu R, Yamaguchi M, Uramaru N, Kuroki H, Ohta S, Kitamura S, Sugihara K.

Toxicology. 2013 Dec 6;314(1):22-9. doi: 10.1016/j.tox.2013.08.017. Epub 2013 Sep 3.

PMID:
24012475
20.

Comparative study of the hydrolytic metabolism of methyl-, ethyl-, propyl-, butyl-, heptyl- and dodecylparaben by microsomes of various rat and human tissues.

Ozaki H, Sugihara K, Watanabe Y, Fujino C, Uramaru N, Sone T, Ohta S, Kitamura S.

Xenobiotica. 2013 Dec;43(12):1064-72. doi: 10.3109/00498254.2013.802059. Epub 2013 Jun 6.

PMID:
23742084

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