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Items: 1 to 20 of 40

1.

A Critical Review of Animal Models Used in Acute Myeloid Leukemia Pathophysiology.

Skayneh H, Jishi B, Hleihel R, Hamieh M, Darwiche N, Bazarbachi A, El Sabban M, El Hajj H.

Genes (Basel). 2019 Aug 13;10(8). pii: E614. doi: 10.3390/genes10080614. Review.

2.

Spinal sarcomas and immunity: An undervalued relationship.

Moussalem CK, Massaad E, Baassiri W, Akhtar Anwar M, Kobeissy F, Eid A, Darwiche N, Omeis I.

Semin Cancer Biol. 2019 Jun 26. pii: S1044-579X(18)30160-3. doi: 10.1016/j.semcancer.2019.06.009. [Epub ahead of print] Review.

PMID:
31254615
3.

Novel therapeutic strategies for spinal osteosarcomas.

Anwar MA, El-Baba C, Elnaggar MH, Elkholy YO, Mottawea M, Johar D, Al Shehabi TS, Kobeissy F, Moussalem C, Massaad E, Omeis I, Darwiche N, Eid AH.

Semin Cancer Biol. 2019 May 29. pii: S1044-579X(18)30156-1. doi: 10.1016/j.semcancer.2019.05.018. [Epub ahead of print] Review.

PMID:
31152785
4.

Natural and synthetic retinoids in preclinical colorectal cancer models.

Abdel-Samad R, Aouad P, Darwiche N.

Anticancer Drugs. 2019 Aug;30(7):e0802. doi: 10.1097/CAD.0000000000000802.

PMID:
31021825
5.

The synthetic retinoid ST1926 attenuates prostate cancer growth and potentially targets prostate cancer stem-like cells.

Bahmad HF, Samman H, Monzer A, Hadadeh O, Cheaito K, Abdel-Samad R, Hayar B, Pisano C, Msheik H, Liu YN, Darwiche N, Abou-Kheir W.

Mol Carcinog. 2019 Jul;58(7):1208-1220. doi: 10.1002/mc.23004. Epub 2019 Mar 18.

PMID:
30883933
6.

Anti-osteogenic function of a LIM-homeodomain transcription factor LMX1B is essential to early patterning of the calvaria.

Cesario JM, Landin Malt A, Chung JU, Khairallah MP, Dasgupta K, Asam K, Deacon LJ, Choi V, Almaidhan AA, Darwiche NA, Kim J, Johnson RL, Jeong J.

Dev Biol. 2018 Nov 15;443(2):103-116. doi: 10.1016/j.ydbio.2018.05.022. Epub 2018 May 28.

PMID:
29852132
7.

Mouse Models That Enhanced Our Understanding of Adult T Cell Leukemia.

Moodad S, Akkouche A, Hleihel R, Darwiche N, El-Sabban M, Bazarbachi A, El Hajj H.

Front Microbiol. 2018 Mar 28;9:558. doi: 10.3389/fmicb.2018.00558. eCollection 2018. Review.

8.

Mechanism of action of the atypical retinoid ST1926 in colorectal cancer: DNA damage and DNA polymerase α.

Abdel-Samad R, Aouad P, Gali-Muhtasib H, Sweidan Z, Hmadi R, Kadara H, D'Andrea EL, Fucci A, Pisano C, Darwiche N.

Am J Cancer Res. 2018 Jan 1;8(1):39-55. eCollection 2018.

9.

Genome-Wide Gene Expression Changes in the Normal-Appearing Airway during the Evolution of Smoking-Associated Lung Adenocarcinoma.

Kantrowitz J, Sinjab A, Xu L, McDowell TL, Sivakumar S, Lang W, Nunomura-Nakamura S, Fukuoka J, Nemer G, Darwiche N, Chami H, Tfayli A, Wistuba II, Scheet P, Fujimoto J, Spira AE, Kadara H.

Cancer Prev Res (Phila). 2018 Apr;11(4):237-248. doi: 10.1158/1940-6207.CAPR-17-0295. Epub 2018 Jan 30.

10.

Antitumor activity of the synthetic retinoid ST1926 on primary effusion lymphoma in vitro and in vivo models.

Karam L, Houshaymi B, Abdel-Samad R, Jaafar M, Halloum I, Pisano C, Neipel F, Darwiche N, Abou Merhi R.

Oncol Rep. 2018 Feb;39(2):721-730. doi: 10.3892/or.2017.6137. Epub 2017 Dec 5.

PMID:
29207182
11.

Antitumor Effect of the Atypical Retinoid ST1926 in Acute Myeloid Leukemia and Nanoparticle Formulation Prolongs Lifespan and Reduces Tumor Burden of Xenograft Mice.

El-Houjeiri L, Saad W, Hayar B, Aouad P, Tawil N, Abdel-Samad R, Hleihel R, Hamie M, Mancinelli A, Pisano C, El Hajj H, Darwiche N.

Mol Cancer Ther. 2017 Oct;16(10):2047-2057. doi: 10.1158/1535-7163.MCT-16-0785. Epub 2017 Jun 15.

12.

Antitumor activities of the synthetic retinoid ST1926 in two-dimensional and three-dimensional human breast cancer models.

Aouad P, Saikali M, Abdel-Samad R, Fostok S, El-Houjeiri L, Pisano C, Talhouk R, Darwiche N.

Anticancer Drugs. 2017 Aug;28(7):757-770. doi: 10.1097/CAD.0000000000000511.

PMID:
28471809
13.

Retinoids: a journey from the molecular structures and mechanisms of action to clinical uses in dermatology and adverse effects.

Khalil S, Bardawil T, Stephan C, Darwiche N, Abbas O, Kibbi AG, Nemer G, Kurban M.

J Dermatolog Treat. 2017 Dec;28(8):684-696. doi: 10.1080/09546634.2017.1309349. Epub 2017 Apr 2. Review.

PMID:
28318351
14.

The synthetic retinoid ST1926 as a novel therapeutic agent in rhabdomyosarcoma.

Basma H, Ghayad SE, Rammal G, Mancinelli A, Harajly M, Ghamloush F, Dweik L, El-Eit R, Zalzali H, Rabeh W, Pisano C, Darwiche N, Saab R.

Int J Cancer. 2016 Mar 15;138(6):1528-37. doi: 10.1002/ijc.29886. Epub 2015 Oct 22.

15.

Cell death mechanisms of plant-derived anticancer drugs: beyond apoptosis.

Gali-Muhtasib H, Hmadi R, Kareh M, Tohme R, Darwiche N.

Apoptosis. 2015 Dec;20(12):1531-62. doi: 10.1007/s10495-015-1169-2. Review.

PMID:
26362468
16.

Retinoic acid and arsenic trioxide trigger degradation of mutated NPM1, resulting in apoptosis of AML cells.

El Hajj H, Dassouki Z, Berthier C, Raffoux E, Ades L, Legrand O, Hleihel R, Sahin U, Tawil N, Salameh A, Zibara K, Darwiche N, Mohty M, Dombret H, Fenaux P, de Thé H, Bazarbachi A.

Blood. 2015 May 28;125(22):3447-54. doi: 10.1182/blood-2014-11-612416. Epub 2015 Mar 23.

17.

Identification of several mutations in ATP2C1 in Lebanese families: insight into the pathogenesis of Hailey-Hailey disease.

Btadini W, Abou Hassan OK, Saadeh D, Abbas O, Ballout F, Kibbi AG, Dbaibo G, Darwiche N, Nemer G, Kurban M.

PLoS One. 2015 Feb 6;10(2):e0115530. doi: 10.1371/journal.pone.0115530. eCollection 2015.

18.

ST1926, an orally active synthetic retinoid, induces apoptosis in chronic myeloid leukemia cells and prolongs survival in a murine model.

Nasr RR, Hmadi RA, El-Eit RM, Iskandarani AN, Jabbour MN, Zaatari GS, Mahon FX, Pisano CC, Darwiche ND.

Int J Cancer. 2015 Aug 1;137(3):698-709. doi: 10.1002/ijc.29407. Epub 2015 Jan 21.

19.

Preclinical efficacy of the synthetic retinoid ST1926 for treating adult T-cell leukemia/lymphoma.

El Hajj H, Khalil B, Ghandour B, Nasr R, Shahine S, Ghantous A, Abdel-Samad R, Sinjab A, Hasegawa H, Jabbour M, Hall WW, Zaatari G, Dbaibo G, Pisano C, Bazarbachi A, Darwiche N.

Blood. 2014 Sep 25;124(13):2072-80. doi: 10.1182/blood-2014-03-560060. Epub 2014 Jul 17.

20.

Differential growth inhibitory effects of highly oxygenated guaianolides isolated from the Middle Eastern indigenous plant Achillea falcata in HCT-116 colorectal cancer cells.

Tohme R, Al Aaraj L, Ghaddar T, Gali-Muhtasib H, Saliba NA, Darwiche N.

Molecules. 2013 Jul 15;18(7):8275-88. doi: 10.3390/molecules18078275.

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