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Items: 20


Supercoil Levels in E. coli and Salmonella Chromosomes Are Regulated by the C-Terminal 35⁻38 Amino Acids of GyrA.

Rovinskiy NS, Agbleke AA, Chesnokova ON, Higgins NP.

Microorganisms. 2019 Mar 15;7(3). pii: E81. doi: 10.3390/microorganisms7030081.


Efficient, ultra-high-affinity chromatography in a one-step purification of complex proteins.

Vassylyeva MN, Klyuyev S, Vassylyev AD, Wesson H, Zhang Z, Renfrow MB, Wang H, Higgins NP, Chow LT, Vassylyev DG.

Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):E5138-E5147. doi: 10.1073/pnas.1704872114. Epub 2017 Jun 12.


Species-specific supercoil dynamics of the bacterial nucleoid.

Higgins NP.

Biophys Rev. 2016 Nov;8(Suppl 1):113-121. doi: 10.1007/s12551-016-0207-9. Epub 2016 Jul 20.


Topological Behavior of Plasmid DNA.

Higgins NP, Vologodskii AV.

Microbiol Spectr. 2015 Apr;3(2). doi: 10.1128/microbiolspec.PLAS-0036-2014. Review.


RNA polymerase: chromosome domain boundary maker and regulator of supercoil density.

Higgins NP.

Curr Opin Microbiol. 2014 Dec;22:138-43. doi: 10.1016/j.mib.2014.10.002. Review.


A human TOP2A core DNA binding X-ray structure reveals topoisomerase subunit dynamics and a potential mechanism for SUMO modulation of decatenation.

Higgins NP.

J Mol Biol. 2012 Dec 7;424(3-4):105-8. doi: 10.1016/j.jmb.2012.10.002. Epub 2012 Oct 4. No abstract available.


Rates of gyrase supercoiling and transcription elongation control supercoil density in a bacterial chromosome.

Rovinskiy N, Agbleke AA, Chesnokova O, Pang Z, Higgins NP.

PLoS Genet. 2012;8(8):e1002845. doi: 10.1371/journal.pgen.1002845. Epub 2012 Aug 16.


DNA topology of highly transcribed operons in Salmonella enterica serovar Typhimurium.

Booker BM, Deng S, Higgins NP.

Mol Microbiol. 2010 Dec;78(6):1348-64. doi: 10.1111/j.1365-2958.2010.07394.x. Epub 2010 Sep 30.


Microarray analysis of Mu transposition in Salmonella enterica, serovar Typhimurium: transposon exclusion by high-density DNA binding proteins.

Manna D, Porwollik S, McClelland M, Tan R, Higgins NP.

Mol Microbiol. 2007 Oct;66(2):315-28. Epub 2007 Sep 10.


Under DNA stress, gyrase makes the sign of the cross.

Higgins NP.

Nat Struct Mol Biol. 2007 Apr;14(4):256-8. No abstract available.


A gyrase mutant with low activity disrupts supercoiling at the replication terminus.

Pang Z, Chen R, Manna D, Higgins NP.

J Bacteriol. 2005 Nov;187(22):7773-83.


Organization of supercoil domains and their reorganization by transcription.

Deng S, Stein RA, Higgins NP.

Mol Microbiol. 2005 Sep;57(6):1511-21. Review.


Bacteriophage Mu targets the trinucleotide sequence CGG.

Manna D, Deng S, Breier AM, Higgins NP.

J Bacteriol. 2005 May;187(10):3586-8.


Rapid tagging of endogenous mouse genes by recombineering and ES cell complementation of tetraploid blastocysts.

Zhou D, Ren JX, Ryan TM, Higgins NP, Townes TM.

Nucleic Acids Res. 2004 Sep 8;32(16):e128.


Microarray analysis of transposition targets in Escherichia coli: the impact of transcription.

Manna D, Breier AM, Higgins NP.

Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9780-5. Epub 2004 Jun 21.


Transcription-induced barriers to supercoil diffusion in the Salmonella typhimurium chromosome.

Deng S, Stein RA, Higgins NP.

Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3398-403. Epub 2004 Mar 1.


Expression of the gene encoding the major bacterial nucleoid protein H-NS is subject to transcriptional auto-repression.

Falconi M, Higgins NP, Spurio R, Pon CL, Gualerzi CO.

Mol Microbiol. 1993 Oct;10(2):273-282. doi: 10.1111/j.1365-2958.1993.tb01953.x.


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