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Items: 12

1.

A novel mtDNA repair fusion protein attenuates maladaptive remodeling and preserves cardiac function in heart failure.

Bradley JM, Li Z, Organ CL, Polhemus DJ, Otsuka H, Islam KN, Bhushan S, Gorodnya OM, Ruchko MV, Gillespie MN, Wilson GL, Lefer DJ.

Am J Physiol Heart Circ Physiol. 2018 Feb 1;314(2):H311-H321. doi: 10.1152/ajpheart.00515.2017. Epub 2017 Nov 3.

2.

Mitochondrial DNA Damage Initiates Acute Lung Injury and Multi-Organ System Failure Evoked in Rats by Intra-Tracheal Pseudomonas Aeruginosa.

Lee YL, Obiako B, Gorodnya OM, Ruchko MV, Kuck JL, Pastukh VM, Wilson GL, Simmons JD, Gillespie MN.

Shock. 2017 Jul;48(1):54-60. doi: 10.1097/SHK.0000000000000838.

3.

Regulation of mitochondrial genome replication by hypoxia: The role of DNA oxidation in D-loop region.

Pastukh VM, Gorodnya OM, Gillespie MN, Ruchko MV.

Free Radic Biol Med. 2016 Jul;96:78-88. doi: 10.1016/j.freeradbiomed.2016.04.011. Epub 2016 Apr 25.

4.

Mitochondrially targeted Endonuclease III has a powerful anti-infarct effect in an in vivo rat model of myocardial ischemia/reperfusion.

Yang XM, Cui L, White J, Kuck J, Ruchko MV, Wilson GL, Alexeyev M, Gillespie MN, Downey JM, Cohen MV.

Basic Res Cardiol. 2015 Mar;110(2):3. doi: 10.1007/s00395-014-0459-0. Epub 2015 Jan 17.

5.

Mitochondrial Targeted Endonuclease III DNA Repair Enzyme Protects against Ventilator Induced Lung Injury in Mice.

Hashizume M, Mouner M, Chouteau JM, Gorodnya OM, Ruchko MV, Wilson GL, Gillespie MN, Parker JC.

Pharmaceuticals (Basel). 2014 Aug 22;7(8):894-912. doi: 10.3390/ph7080894.

6.

Mitochondrial-targeted DNA repair enzyme 8-oxoguanine DNA glycosylase 1 protects against ventilator-induced lung injury in intact mice.

Hashizume M, Mouner M, Chouteau JM, Gorodnya OM, Ruchko MV, Potter BJ, Wilson GL, Gillespie MN, Parker JC.

Am J Physiol Lung Cell Mol Physiol. 2013 Feb 15;304(4):L287-97. doi: 10.1152/ajplung.00071.2012. Epub 2012 Dec 14.

7.

Mitochondrial DNA integrity may be a determinant of endothelial barrier properties in oxidant-challenged rat lungs.

Chouteau JM, Obiako B, Gorodnya OM, Pastukh VM, Ruchko MV, Wright AJ, Wilson GL, Gillespie MN.

Am J Physiol Lung Cell Mol Physiol. 2011 Dec;301(6):L892-8. doi: 10.1152/ajplung.00210.2011. Epub 2011 Sep 2.

8.

Oxidative DNA damage in lung tissue from patients with COPD is clustered in functionally significant sequences.

Pastukh VM, Zhang L, Ruchko MV, Gorodnya O, Bardwell GC, Tuder RM, Gillespie MN.

Int J Chron Obstruct Pulmon Dis. 2011;6:209-17. doi: 10.2147/COPD.S15922. Epub 2011 Mar 13.

9.

The DNA glycosylase Ogg1 defends against oxidant-induced mtDNA damage and apoptosis in pulmonary artery endothelial cells.

Ruchko MV, Gorodnya OM, Zuleta A, Pastukh VM, Gillespie MN.

Free Radic Biol Med. 2011 May 1;50(9):1107-13. doi: 10.1016/j.freeradbiomed.2010.10.692. Epub 2010 Oct 20.

10.

Controlled DNA "damage" and repair in hypoxic signaling.

Gillespie MN, Pastukh VM, Ruchko MV.

Respir Physiol Neurobiol. 2010 Dec 31;174(3):244-51. doi: 10.1016/j.resp.2010.08.025. Epub 2010 Sep 8. Review.

11.

Oxidative DNA modifications in hypoxic signaling.

Gillespie MN, Pastukh V, Ruchko MV.

Ann N Y Acad Sci. 2009 Oct;1177:140-50. doi: 10.1111/j.1749-6632.2009.05036.x.

PMID:
19845616
12.

Hypoxia-induced oxidative base modifications in the VEGF hypoxia-response element are associated with transcriptionally active nucleosomes.

Ruchko MV, Gorodnya OM, Pastukh VM, Swiger BM, Middleton NS, Wilson GL, Gillespie MN.

Free Radic Biol Med. 2009 Feb 1;46(3):352-9. doi: 10.1016/j.freeradbiomed.2008.09.038. Epub 2008 Oct 18.

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