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Psychosomatics. 2006 Sep-Oct;47(5):440-2.

Mirtazapine for severe gastroparesis unresponsive to conventional prokinetic treatment.

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Department of Psychiatry, Chonnam National Univ. Hospital, 8 Hak-dong, Dong-ku, Kwangju 501-757, Republic of Korea.


Gastroparesis is a condition of abnormal gastric motility characterized by delayed gastric emptying without evidence of mechanical outlet obstruction. The authors describe complete remission of recurrent postprandial discomfort, nausea, and vomiting within 1 week of starting mirtazapine in a gastroparetic patient who had failed to respond, in 7 months, to conventional prokinetics (erythromycin, metoclopramide, domperidone, perphenazine, itopride, bethanechol, and/or tegaserod) and pyloric injection of botulinum toxin. This is the first report to show that mirtazapine may be an effective alternative when gastroparesis is refractory to conventional measures.

[Indexed for MEDLINE]

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