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Mar Drugs. 2017 Jan 18;15(1). pii: E19. doi: 10.3390/md15010019.

New Enzyme-Inhibitory Triterpenoid from Marine Macro Brown Alga Padina boergesenii Allender & Kraft.

Author information

1
UoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Birkat Al-Mouz, Nizwa-616, Oman. malikhejric@gmail.com.
2
UoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Birkat Al-Mouz, Nizwa-616, Oman. latifepm78@yahoo.co.uk.
3
UoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Birkat Al-Mouz, Nizwa-616, Oman. albroumi@unizwa.edu.om.
4
UoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Birkat Al-Mouz, Nizwa-616, Oman. rashid@unizwa.edu.om.
5
Marine Science and Fisheries Center, Ministry of Agriculture and Fisheries Resources, Muscat-113, Oman. lubna.alkharusi@gmail.com.
6
UoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Birkat Al-Mouz, Nizwa-616, Oman. javidhej@unizwa.edu.om.
7
Department of Biological Sciences and Chemistry, University of Nizwa, Birkat Al-Mauz, Nizwa-616, Oman. javidhej@unizwa.edu.om.
8
UoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Birkat Al-Mouz, Nizwa-616, Oman. aharrasi@unizwa.edu.om.
9
Department of Biological Sciences and Chemistry, University of Nizwa, Birkat Al-Mauz, Nizwa-616, Oman. aharrasi@unizwa.edu.om.

Abstract

In continuation to our study of the chemical and biological potential of the secondary metabolites isolated from Omani seaweeds, we investigated a marine brown alga, Padina boergesenii. The phytochemical investigation resulted in the isolation of a new secondary metabolite, padinolic acid (1), along with some other semi-pure fractions and sub-fractions. The planar structure was confirmed through MS and NMR (1D and 2D) spectral data. The NOESY experiments coupled with the biogenetic consideration were helpful in assigning the stereochemistry in the molecule. Compound 1 was subjected to enzyme inhibition studies using urease, lipid peroxidase, and alpha-glucosidase enzymes. Compound 1 showed low to moderate α-glucosidase and urease enzyme inhibition, respectively, and moderate anti-lipid peroxidation activities. The current study indicates the potential of this seaweed and provides the basis for further investigation.

KEYWORDS:

Padina boergesenii; enzyme inhibition; phytochemical investigation; structure elucidation

PMID:
28106757
PMCID:
PMC5295239
DOI:
10.3390/md15010019
[Indexed for MEDLINE]
Free PMC Article

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