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Items: 7


Disease Associated Mutations in KIR Proteins Linked to Aberrant Inward Rectifier Channel Trafficking.

Zangerl-Plessl EM, Qile M, Bloothooft M, Stary-Weinzinger A, van der Heyden MAG.

Biomolecules. 2019 Oct 25;9(11). pii: E650. doi: 10.3390/biom9110650. Review.


LUF7244, an allosteric modulator/activator of Kv 11.1 channels, counteracts dofetilide-induced torsades de pointes arrhythmia in the chronic atrioventricular block dog model.

Qile M, Beekman HDM, Sprenkeler DJ, Houtman MJC, van Ham WB, Stary-Weinzinger A, Beyl S, Hering S, van den Berg DJ, de Lange ECM, Heitman LH, IJzerman AP, Vos MA, van der Heyden MAG.

Br J Pharmacol. 2019 Oct;176(19):3871-3885. doi: 10.1111/bph.14798. Epub 2019 Aug 30.


Identification of a PEST Sequence in Vertebrate KIR2.1 That Modifies Rectification.

Qile M, Ji Y, Houtman MJC, Veldhuis M, Romunde F, Kok B, van der Heyden MAG.

Front Physiol. 2019 Jul 5;10:863. doi: 10.3389/fphys.2019.00863. eCollection 2019.


Glibenclamide and HMR1098 normalize Cant├║ syndrome-associated gain-of-function currents.

Houtman MJC, Chen X, Qile M, Duran K, van Haaften G, Stary-Weinzinger A, van der Heyden MAG.

J Cell Mol Med. 2019 Aug;23(8):4962-4969. doi: 10.1111/jcmm.14329. Epub 2019 May 22.


Class III antiarrhythmic drugs amiodarone and dronedarone impair KIR 2.1 backward trafficking.

Ji Y, Takanari H, Qile M, Nalos L, Houtman MJC, Romunde FL, Heukers R, van Bergen En Henegouwen PMP, Vos MA, van der Heyden MAG.

J Cell Mol Med. 2017 Oct;21(10):2514-2523. doi: 10.1111/jcmm.13172. Epub 2017 Apr 19.


Downregulation of miR-21 is involved in direct actions of ursolic acid on the heart: implications for cardiac fibrosis and hypertrophy.

Dong X, Liu S, Zhang L, Yu S, Huo L, Qile M, Liu L, Yang B, Yu J.

Cardiovasc Ther. 2015 Aug;33(4):161-7. doi: 10.1111/1755-5922.12125.


Simvastatin alleviates cardiac fibrosis induced by infarction via up-regulation of TGF-╬▓ receptor III expression.

Sun F, Duan W, Zhang Y, Zhang L, Qile M, Liu Z, Qiu F, Zhao D, Lu Y, Chu W.

Br J Pharmacol. 2015 Aug;172(15):3779-92. doi: 10.1111/bph.13166. Epub 2015 Jun 12.

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