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Items: 1 to 20 of 222

1.

Selegiline: a molecule with innovative potential.

Tábi T, Vécsei L, Youdim MB, Riederer P, Szökő É.

J Neural Transm (Vienna). 2019 Sep 27. doi: 10.1007/s00702-019-02082-0. [Epub ahead of print] Review.

PMID:
31562557
2.

Monoamine oxidase inhibitors, and iron chelators in depressive illness and neurodegenerative diseases.

Youdim MBH.

J Neural Transm (Vienna). 2018 Nov;125(11):1719-1733. doi: 10.1007/s00702-018-1942-9. Epub 2018 Oct 19. Review.

PMID:
30341696
3.

A promising drug candidate for the treatment of glaucoma based on a P2Y6-receptor agonist.

Jacob TF, Singh V, Dixit M, Ginsburg-Shmuel T, Fonseca B, Pintor J, Youdim MBH, Major DT, Weinreb O, Fischer B.

Purinergic Signal. 2018 Sep;14(3):271-284. doi: 10.1007/s11302-018-9614-7. Epub 2018 Jul 17.

4.

Differential Alterations in Metabolism and Proteolysis-Related Proteins in Human Parkinson's Disease Substantia Nigra.

Grünblatt E, Ruder J, Monoranu CM, Riederer P, Youdim MB, Mandel SA.

Neurotox Res. 2018 Apr;33(3):560-568. doi: 10.1007/s12640-017-9843-5. Epub 2017 Dec 7.

PMID:
29218503
5.

Iron-Chelating Drugs Enhance Cone Photoreceptor Survival in a Mouse Model of Retinitis Pigmentosa.

Wang K, Peng B, Xiao J, Weinreb O, Youdim MBH, Lin B.

Invest Ophthalmol Vis Sci. 2017 Oct 1;58(12):5287-5297. doi: 10.1167/iovs.17-22096.

PMID:
29049732
6.

Monoamine oxidase A upregulated by chronic intermittent hypoxia activates indoleamine 2,3-dioxygenase and neurodegeneration.

Lam CS, Li JJ, Tipoe GL, Youdim MBH, Fung ML.

PLoS One. 2017 Jun 9;12(6):e0177940. doi: 10.1371/journal.pone.0177940. eCollection 2017.

7.

The novel multitarget iron chelating and propargylamine drug M30 affects APP regulation and processing activities in Alzheimer's disease models.

Amit T, Bar-Am O, Mechlovich D, Kupershmidt L, Youdim MBH, Weinreb O.

Neuropharmacology. 2017 Sep 1;123:359-367. doi: 10.1016/j.neuropharm.2017.05.026. Epub 2017 May 29. Review.

PMID:
28571715
8.

The involvement of BDNF-CREB signaling pathways in the pharmacological mechanism of combined SSRI- antipsychotic treatment in schizophrenia.

Einoch R, Weinreb O, Mandiuk N, Youdim MBH, Bilker W, Silver H.

Eur Neuropsychopharmacol. 2017 May;27(5):470-483. doi: 10.1016/j.euroneuro.2017.03.005. Epub 2017 Apr 11.

PMID:
28410959
9.

Anti-inflammatory and protective effects of MT-031, a novel multitarget MAO-A and AChE/BuChE inhibitor in scopolamine mouse model and inflammatory cells.

Liu W, Rabinovich A, Nash Y, Frenkel D, Wang Y, Youdim MBH, Weinreb O.

Neuropharmacology. 2017 Feb;113(Pt A):445-456. doi: 10.1016/j.neuropharm.2016.10.028. Epub 2016 Oct 28.

PMID:
27984078
10.

M30 Antagonizes Indoleamine 2,3-Dioxygenase Activation and Neurodegeneration Induced by Corticosterone in the Hippocampus.

Lam CS, Tipoe GL, Wong JK, Youdim MB, Fung ML.

PLoS One. 2016 Nov 21;11(11):e0166966. doi: 10.1371/journal.pone.0166966. eCollection 2016.

11.

A Novel Iron Chelator-Radical Scavenger Ameliorates Motor Dysfunction and Improves Life Span and Mitochondrial Biogenesis in SOD1G93A ALS Mice.

Golko-Perez S, Amit T, Bar-Am O, Youdim MB, Weinreb O.

Neurotox Res. 2017 Feb;31(2):230-244. doi: 10.1007/s12640-016-9677-6. Epub 2016 Nov 8.

PMID:
27826939
12.

N-Methyl, N-propynyl-2-phenylethylamine (MPPE), a Selegiline Analog, Attenuates MPTP-induced Dopaminergic Toxicity with Guaranteed Behavioral Safety: Involvement of Inhibitions of Mitochondrial Oxidative Burdens and p53 Gene-elicited Pro-apoptotic Change.

Shin EJ, Nam Y, Lee JW, Nguyen PT, Yoo JE, Tran TV, Jeong JH, Jang CG, Oh YJ, Youdim MBH, Lee PH, Nabeshima T, Kim HC.

Mol Neurobiol. 2016 Nov;53(9):6251-6269. doi: 10.1007/s12035-015-9527-1. Epub 2015 Nov 13.

PMID:
26563498
13.

Neurorescue by a ROS Decomposition Catalyst.

Soll M, Bar Am O, Mahammed A, Saltsman I, Mandel S, Youdim MB, Gross Z.

ACS Chem Neurosci. 2016 Oct 19;7(10):1374-1382. Epub 2016 Aug 5.

PMID:
27442690
14.

Inhibition of caspase-9 aggravates acute liver injury through suppression of cytoprotective autophagy.

Guo R, Lin B, Pan JF, Liong EC, Xu AM, Youdim M, Fung ML, So KF, Tipoe GL.

Sci Rep. 2016 Sep 1;6:32447. doi: 10.1038/srep32447.

15.

Design, synthesis and evaluation of novel dual monoamine-cholinesterase inhibitors as potential treatment for Alzheimer's disease.

Liu W, Lang M, Youdim MBH, Amit T, Sun Y, Zhang Z, Wang Y, Weinreb O.

Neuropharmacology. 2016 Oct;109:376-385. doi: 10.1016/j.neuropharm.2016.06.013. Epub 2016 Jun 16.

PMID:
27318273
16.

Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease.

Unzeta M, Esteban G, Bolea I, Fogel WA, Ramsay RR, Youdim MB, Tipton KF, Marco-Contelles J.

Front Neurosci. 2016 May 25;10:205. doi: 10.3389/fnins.2016.00205. eCollection 2016. Review.

17.

Beneficial Effects of Multitarget Iron Chelator on Central Nervous System and Gastrocnemius Muscle in SOD1(G93A) Transgenic ALS Mice.

Golko-Perez S, Amit T, Youdim MB, Weinreb O.

J Mol Neurosci. 2016 Aug;59(4):504-10. doi: 10.1007/s12031-016-0763-2. Epub 2016 May 13.

PMID:
27173029
18.

Binge ethanol exposure increases the Krüppel-like factor 11-monoamine oxidase (MAO) pathway in rats: Examining the use of MAO inhibitors to prevent ethanol-induced brain injury.

Duncan JW, Zhang X, Wang N, Johnson S, Harris S, Udemgba C, Ou XM, Youdim MB, Stockmeier CA, Wang JM.

Neuropharmacology. 2016 Jun;105:329-340. doi: 10.1016/j.neuropharm.2016.01.024. Epub 2016 Jan 22.

19.

Additive Neuroprotective Effects of the Multifunctional Iron Chelator M30 with Enriched Diet in a Mouse Model of Amyotrophic Lateral Sclerosis.

Golko-Perez S, Mandel S, Amit T, Kupershmidt L, Youdim MB, Weinreb O.

Neurotox Res. 2016 Feb;29(2):208-17. doi: 10.1007/s12640-015-9574-4. Epub 2015 Nov 18.

PMID:
26581376
20.

The Multi-Target Drug M30 Shows Pro-Cognitive and Anti-Inflammatory Effects in a Rat Model of Alzheimer's Disease.

Pimentel LS, Allard S, Do Carmo S, Weinreb O, Danik M, Hanzel CE, Youdim MB, Cuello AC.

J Alzheimers Dis. 2015;47(2):373-83. doi: 10.3233/JAD-143126.

PMID:
26401560

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