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Noncoding RNA. 2019 Mar 12;5(1). pii: E23. doi: 10.3390/ncrna5010023.

The MicroRNA miR-155 Is Essential in Fibrosis.

Author information

1
Department of Microbiology & Immunology, Drexel University College of Medicine, Drexel University, 2900 Queen Lane, Philadelphia, PA 19129, USA. mosa1034@gmail.com.
2
Department of Microbiology & Immunology, Drexel University College of Medicine, Drexel University, 2900 Queen Lane, Philadelphia, PA 19129, USA. carol.artlett@drexelmed.edu.

Abstract

The function of microRNAs (miRNAs) during fibrosis and the downstream regulation of gene expression by these miRNAs have become of great biological interest. miR-155 is consistently upregulated in fibrotic disorders, and its ablation downregulates collagen synthesis. Studies demonstrate the integral role of miR-155 in fibrosis, as it mediates TGF-β1 signaling to drive collagen synthesis. In this review, we summarize recent findings on the association between miR-155 and fibrotic disorders. We discuss the cross-signaling between macrophages and fibroblasts that orchestrates the upregulation of collagen synthesis mediated by miR-155. As miR-155 is involved in the activation of the innate and adaptive immune systems, specific targeting of miR-155 in pathologic cells that make excessive collagen could be a viable option before the depletion of miR-155 becomes an attractive antifibrotic approach.

KEYWORDS:

TGF-β1; fibroblasts; fibrosis; inflammasome; miR-155

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