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Mineralocorticoid Receptor May Regulate Glucose Homeostasis through the Induction of Interleukin-6 and Glucagon-Like peptide-1 in Pancreatic Islets.

Goto R, Kondo T, Ono K, Kitano S, Miyakawa N, Watanabe T, Sakaguchi M, Sato M, Igata M, Kawashima J, Motoshima H, Matsumura T, Shimoda S, Araki E.

J Clin Med. 2019 May 14;8(5). pii: E674. doi: 10.3390/jcm8050674.


Impact of hepatic HSP72 on insulin signaling.

Kitano S, Kondo T, Matsuyama R, Ono K, Goto R, Takaki Y, Hanatani S, Sakaguchi M, Igata M, Kawashima J, Motoshima H, Matsumura T, Kai H, Araki E.

Am J Physiol Endocrinol Metab. 2019 Feb 1;316(2):E305-E318. doi: 10.1152/ajpendo.00215.2018. Epub 2018 Dec 11.


A Rare Case of Thyrotropin-Secreting Pituitary Adenoma Coexisting with Papillary Thyroid Carcinoma Presenting with Visual Disturbance without Hyperthyroidism.

Inoue H, Shinojima N, Ueda R, Yamamoto K, Ishii N, Igata M, Kawashima J, Araki E, Iwase H, Mikami Y, Yano S, Mukasa A.

World Neurosurg. 2018 Nov;119:394-399. doi: 10.1016/j.wneu.2018.07.274. Epub 2018 Aug 7.


Impacts of the 2016 Kumamoto Earthquake on glycemic control in patients with diabetes.

Kondo T, Miyakawa N, Motoshima H, Hanatani S, Ishii N, Igata M, Yoshinaga K, Kukidome D, Senokuchi T, Kawashima J, Furukawa N, Matsumura T, Araki E.

J Diabetes Investig. 2019 Mar;10(2):521-530. doi: 10.1111/jdi.12891. Epub 2018 Aug 1.


Identification of microRNA that represses IRS-1 expression in liver.

Ono K, Igata M, Kondo T, Kitano S, Takaki Y, Hanatani S, Sakaguchi M, Goto R, Senokuchi T, Kawashima J, Furukawa N, Motoshima H, Araki E.

PLoS One. 2018 Jan 24;13(1):e0191553. doi: 10.1371/journal.pone.0191553. eCollection 2018.


Acetate alters expression of genes involved in beige adipogenesis in 3T3-L1 cells and obese KK-Ay mice.

Hanatani S, Motoshima H, Takaki Y, Kawasaki S, Igata M, Matsumura T, Kondo T, Senokuchi T, Ishii N, Kawashima J, Kukidome D, Shimoda S, Nishikawa T, Araki E.

J Clin Biochem Nutr. 2016 Nov;59(3):207-214. Epub 2016 Sep 8.


Activation of heat shock response to treat obese subjects with type 2 diabetes: a prospective, frequency-escalating, randomized, open-label, triple-arm trial.

Kondo T, Goto R, Ono K, Kitano S, Suico MA, Sato M, Igata M, Kawashima J, Motoshima H, Matsumura T, Kai H, Araki E.

Sci Rep. 2016 Oct 19;6:35690. doi: 10.1038/srep35690.


A 1-year, prospective, observational study of Japanese outpatients with type 1 and type 2 diabetes switching from insulin glargine or detemir to insulin degludec in basal-bolus insulin therapy (Kumamoto Insulin Degludec Observational study).

Shimoda S, Sato M, Sekigami T, Motoshima H, Yoshimura R, Fukuda K, Matsuo Y, Noda H, Okubo M, Ichimori S, Fujisawa K, Fukunaga M, Araki E; Kumamoto Insulin Degludec Observational (KIDUNA) Study Group.

J Diabetes Investig. 2016 Sep;7(5):703-10. doi: 10.1111/jdi.12496. Epub 2016 Mar 19.


Coexistence of resistance to thyroid hormone and papillary thyroid carcinoma.

Igata M, Tsuruzoe K, Kawashima J, Kukidome D, Kondo T, Motoshima H, Shimoda S, Furukawa N, Nishikawa T, Miyamura N, Araki E.

Endocrinol Diabetes Metab Case Rep. 2016;2016:160003. doi: 10.1530/EDM-16-0003. Epub 2016 Mar 30.


Mild Electrical Stimulation with Heat Shock Reduces Visceral Adiposity and Improves Metabolic Abnormalities in Subjects with Metabolic Syndrome or Type 2 Diabetes: Randomized Crossover Trials.

Kondo T, Ono K, Kitano S, Matsuyama R, Goto R, Suico MA, Kawasaki S, Igata M, Kawashima J, Motoshima H, Matsumura T, Kai H, Araki E.

EBioMedicine. 2014 Nov 11;1(1):80-9. doi: 10.1016/j.ebiom.2014.11.001. eCollection 2014 Nov.


Insulin requirement profiles in Japanese hospitalized subjects with type 2 diabetes treated with basal-bolus insulin therapy.

Shimoda S, Okubo M, Koga K, Sekigami T, Kawashima J, Kukidome D, Igata M, Ishii N, Shimakawa A, Matsumura T, Motoshima H, Furukawa N, Nishida K, Araki E.

Endocr J. 2015;62(2):209-16. doi: 10.1507/endocrj.EJ14-0487. Epub 2014 Nov 11.


Prolonged hyponatremia due to hypopituitarism in a patient with non-ST-elevation myocardial infarction.

Marume K, Arima Y, Igata M, Nishikawa T, Yamamoto E, Yamamuro M, Tsujita K, Tanaka T, Kaikita K, Hokimoto S, Ogawa H.

J Cardiol Cases. 2014 Aug 30;10(6):226-230. doi: 10.1016/j.jccase.2014.08.002. eCollection 2014 Dec.


The role of heat shock response in insulin resistance and diabetes.

Kondo T, Motoshima H, Igata M, Kawashima J, Matsumura T, Kai H, Araki E.

Diabetes Metab J. 2014 Apr;38(2):100-6. doi: 10.4093/dmj.2014.38.2.100. Review.


Effects of combination therapy with vildagliptin and valsartan in a mouse model of type 2 diabetes.

Miyagawa K, Kondo T, Goto R, Matsuyama R, Ono K, Kitano S, Kawasaki S, Igata M, Kawashima J, Matsumura T, Motoshima H, Araki E.

Cardiovasc Diabetol. 2013 Nov 4;12:160. doi: 10.1186/1475-2840-12-160.


Regulation of TNF╬▒ converting enzyme activity in visceral adipose tissue of obese mice.

Kawasaki S, Motoshima H, Hanatani S, Takaki Y, Igata M, Tsutsumi A, Matsumura T, Kondo T, Senokuchi T, Ishii N, Kinoshita H, Fukuda K, Kawashima J, Shimoda S, Nishikawa T, Araki E.

Biochem Biophys Res Commun. 2013 Jan 25;430(4):1189-94. doi: 10.1016/j.bbrc.2012.12.086. Epub 2012 Dec 27.


CRTC3 links catecholamine signalling to energy balance.

Song Y, Altarejos J, Goodarzi MO, Inoue H, Guo X, Berdeaux R, Kim JH, Goode J, Igata M, Paz JC, Hogan MF, Singh PK, Goebel N, Vera L, Miller N, Cui J, Jones MR; CHARGE Consortium; GIANT Consortium, Chen YD, Taylor KD, Hsueh WA, Rotter JI, Montminy M.

Nature. 2010 Dec 16;468(7326):933-9. doi: 10.1038/nature09564.


Caloric restriction decreases ER stress in liver and adipose tissue in ob/ob mice.

Tsutsumi A, Motoshima H, Kondo T, Kawasaki S, Matsumura T, Hanatani S, Igata M, Ishii N, Kinoshita H, Kawashima J, Taketa K, Furukawa N, Tsuruzoe K, Nishikawa T, Araki E.

Biochem Biophys Res Commun. 2011 Jan 7;404(1):339-44. doi: 10.1016/j.bbrc.2010.11.120. Epub 2010 Dec 4.


Rottlerin activates AMPK possibly through LKB1 in vascular cells and tissues.

Kojima K, Motoshima H, Tsutsumi A, Igata M, Matsumura T, Kondo T, Kawashima J, Ichinose K, Furukawa N, Inukai K, Katayama S, Goldstein BJ, Nishikawa T, Tsuruzoe K, Araki E.

Biochem Biophys Res Commun. 2008 Nov 14;376(2):434-8. doi: 10.1016/j.bbrc.2008.09.007. Epub 2008 Sep 19.


IRS-1 transgenic mice show increased epididymal fat mass and insulin resistance.

Murata Y, Tsuruzoe K, Kawashima J, Furukawa N, Kondo T, Motoshima H, Igata M, Taketa K, Sasaki K, Kishikawa H, Kahn CR, Toyonaga T, Araki E.

Biochem Biophys Res Commun. 2007 Dec 14;364(2):301-7. Epub 2007 Oct 12.


AMPK and cell proliferation--AMPK as a therapeutic target for atherosclerosis and cancer.

Motoshima H, Goldstein BJ, Igata M, Araki E.

J Physiol. 2006 Jul 1;574(Pt 1):63-71. Epub 2006 Apr 13. Review.

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