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Items: 1 to 20 of 77

1.

Target Identification of the Marine Natural Products Dictyoceratin-A and -C as Selective Growth Inhibitors in Cancer Cells Adapted to Hypoxic Environments.

Kawachi T, Tanaka S, Fukuda A, Sumii Y, Setiawan A, Kotoku N, Kobayashi M, Arai M.

Mar Drugs. 2019 Mar 8;17(3). pii: E163. doi: 10.3390/md17030163.

2.

Structure-Activity Relationship of Biakamide, Selective Growth Inhibitors under Nutrient-Starved Condition from Marine Sponge.

Ishida R, Matsumoto H, Ichii S, Kobayashi M, Arai M, Kotoku N.

Chem Pharm Bull (Tokyo). 2019 Mar 1;67(3):210-223. doi: 10.1248/cpb.c18-00587. Epub 2018 Nov 14.

3.
4.

Biakamides A-D, Unique Polyketides from a Marine Sponge, Act as Selective Growth Inhibitors of Tumor Cells Adapted to Nutrient Starvation.

Kotoku N, Ishida R, Matsumoto H, Arai M, Toda K, Setiawan A, Muraoka O, Kobayashi M.

J Org Chem. 2017 Feb 3;82(3):1705-1718. doi: 10.1021/acs.joc.6b02948. Epub 2017 Jan 25.

PMID:
28090774
5.

Marine spongean polybrominated diphenyl ethers, selective growth inhibitors against the cancer cells adapted to glucose starvation, inhibits mitochondrial complex II.

Arai M, Shin D, Kamiya K, Ishida R, Setiawan A, Kotoku N, Kobayashi M.

J Nat Med. 2017 Jan;71(1):44-49. doi: 10.1007/s11418-016-1025-x. Epub 2016 Jul 23.

PMID:
27449332
6.

N-Methylniphatyne A, a New 3-Alkylpyridine Alkaloid as an Inhibitor of the Cancer Cells Adapted to Nutrient Starvation, from an Indonesian Marine Sponge of Xestospongia sp.

Arai M, Kamiya K, Shin D, Matsumoto H, Hisa T, Setiawan A, Kotoku N, Kobayashi M.

Chem Pharm Bull (Tokyo). 2016;64(7):766-71. doi: 10.1248/cpb.c16-00118.

7.

Anti-dormant mycobacterial activity and target molecule of melophlins, tetramic acid derivatives isolated from a marine sponge of Melophlus sp.

Arai M, Yamano Y, Kamiya K, Setiawan A, Kobayashi M.

J Nat Med. 2016 Jul;70(3):467-75. doi: 10.1007/s11418-016-1005-1. Epub 2016 May 19.

PMID:
27193014
8.

Search for Anti-angiogenic Substances from Natural Sources.

Kotoku N, Arai M, Kobayashi M.

Chem Pharm Bull (Tokyo). 2016;64(2):128-34. doi: 10.1248/cpb.c15-00744. Review.

9.

Structure-Activity Relationship and in Vivo Anti-Tumor Evaluations of Dictyoceratin-A and -C, Hypoxia-Selective Growth Inhibitors from Marine Sponge.

Sumii Y, Kotoku N, Fukuda A, Kawachi T, Arai M, Kobayashi M.

Mar Drugs. 2015 Dec 16;13(12):7419-32. doi: 10.3390/md13127074.

10.

Furospinosulin-1, Marine Spongean Furanosesterterpene, Suppresses the Growth of Hypoxia-Adapted Cancer Cells by Binding to Transcriptional Regulators p54(nrb) and LEDGF/p75.

Arai M, Kawachi T, Kotoku N, Nakata C, Kamada H, Tsunoda S, Tsutsumi Y, Endo H, Inoue M, Sato H, Kobayashi M.

Chembiochem. 2016 Jan;17(2):181-9. doi: 10.1002/cbic.201500519. Epub 2015 Dec 9.

PMID:
26561285
11.

Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp.

Arai M, Kamiya K, Pruksakorn P, Sumii Y, Kotoku N, Joubert JP, Moodley P, Han C, Shin D, Kobayashi M.

Bioorg Med Chem. 2015 Jul 1;23(13):3534-41. doi: 10.1016/j.bmc.2015.04.033. Epub 2015 Apr 17.

PMID:
25934225
12.

Enantioselective synthesis of dictyoceratin-A (smenospondiol) and -C, hypoxia-selective growth inhibitors from marine sponge.

Sumii Y, Kotoku N, Fukuda A, Kawachi T, Sumii Y, Arai M, Kobayashi M.

Bioorg Med Chem. 2015 Mar 1;23(5):966-75. doi: 10.1016/j.bmc.2015.01.021. Epub 2015 Jan 19.

PMID:
25659617
13.

Xylarianaphthol-1, a novel dinaphthofuran derivative, activates p21 promoter in a p53-independent manner.

Kotoku N, Higashimoto K, Kurioka M, Arai M, Fukuda A, Sumii Y, Sowa Y, Sakai T, Kobayashi M.

Bioorg Med Chem Lett. 2014 Aug 1;24(15):3389-91. doi: 10.1016/j.bmcl.2014.05.083. Epub 2014 Jun 4.

PMID:
24939757
14.

Marine spongian sesquiterpene phenols, dictyoceratin-C and smenospondiol, display hypoxia-selective growth inhibition against cancer cells.

Arai M, Kawachi T, Sato H, Setiawan A, Kobayashi M.

Bioorg Med Chem Lett. 2014 Jul 15;24(14):3155-7. doi: 10.1016/j.bmcl.2014.04.116. Epub 2014 May 9.

PMID:
24865416
15.

Synthesis and evaluation of effective photoaffinity probe molecule of furospinosulin-1, a hypoxia-selective growth inhibitor.

Kotoku N, Nakata C, Kawachi T, Sato T, Guo XH, Ito A, Sumii Y, Arai M, Kobayashi M.

Bioorg Med Chem. 2014 Apr 1;22(7):2102-12. doi: 10.1016/j.bmc.2014.02.026. Epub 2014 Mar 4.

PMID:
24631363
16.

Aaptamines, marine spongean alkaloids, as anti-dormant mycobacterial substances.

Arai M, Han C, Yamano Y, Setiawan A, Kobayashi M.

J Nat Med. 2014 Apr;68(2):372-6. doi: 10.1007/s11418-013-0811-y. Epub 2014 Jan 12.

PMID:
24414399
17.

Identification of the target protein of agelasine D, a marine sponge diterpene alkaloid, as an anti-dormant mycobacterial substance.

Arai M, Yamano Y, Setiawan A, Kobayashi M.

Chembiochem. 2014 Jan 3;15(1):117-23. doi: 10.1002/cbic.201300470. Epub 2013 Nov 14.

PMID:
24243718
18.

Synthetic studies of cortistatin A analogue from the CD-ring fragment of vitamin Dâ‚‚.

Kotoku N, Mizushima K, Tamura S, Kobayashi M.

Chem Pharm Bull (Tokyo). 2013;61(10):1024-9.

19.

Creation of readily accessible and orally active analogue of cortistatin a.

Kotoku N, Sumii Y, Hayashi T, Tamura S, Kawachi T, Shiomura S, Arai M, Kobayashi M.

ACS Med Chem Lett. 2012 Jul 10;3(8):673-7. doi: 10.1021/ml300143d. eCollection 2012 Aug 9.

20.

Neamphamide B, new cyclic depsipeptide, as an anti-dormant mycobacterial substance from a Japanese marine sponge of Neamphius sp.

Yamano Y, Arai M, Kobayashi M.

Bioorg Med Chem Lett. 2012 Jul 15;22(14):4877-81. doi: 10.1016/j.bmcl.2012.05.071. Epub 2012 May 24.

PMID:
22704240

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