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Items: 1 to 20 of 41


Antinociceptive Effects of Cardamonin in Mice: Possible Involvement of TRPV₁, Glutamate, and Opioid Receptors.

Ping CP, Tengku Mohamad TAS, Akhtar MN, Perimal EK, Akira A, Israf Ali DA, Sulaiman MR.

Molecules. 2018 Sep 3;23(9). pii: E2237. doi: 10.3390/molecules23092237.


Analgesic Effect of 5-(3,4-Dihydroxyphenyl)-3-hydroxy-1-(2-hydroxyphenyl)penta-2,4-dien-1-one in Experimental Animal Models of Nociception.

Kamarudin N, Hisamuddin N, Ong HM, Ahmad Azmi AF, Leong SW, Abas F, Sulaiman MR, Shaik Mossadeq WM.

Molecules. 2018 Aug 21;23(9). pii: E2099. doi: 10.3390/molecules23092099.


The Protective Effects of a Synthetic Geranyl Acetophenone in a Cellular Model of TNF-α-Induced Pulmonary Epithelial Barrier Dysfunction.

Sim TY, Harith HH, Tham CL, Md Hashim NF, Shaari K, Sulaiman MR, Israf DA.

Molecules. 2018 Jun 5;23(6). pii: E1355. doi: 10.3390/molecules23061355.


Antiallodynic and antihyperalgesic activities of zerumbone via the suppression of IL-1β, IL-6, and TNF-α in a mouse model of neuropathic pain.

Gopalsamy B, Farouk AAO, Tengku Mohamad TAS, Sulaiman MR, Perimal EK.

J Pain Res. 2017 Nov 8;10:2605-2619. doi: 10.2147/JPR.S143024. eCollection 2017.


Zerumbone Alleviates Neuropathic Pain through the Involvement of l-Arginine-Nitric Oxide-cGMP-K⁺ ATP Channel Pathways in Chronic Constriction Injury in Mice Model.

Zulazmi NA, Gopalsamy B, Min JC, Farouk AA, Sulaiman MR, Bharatham BH, Perimal EK.

Molecules. 2017 Mar 30;22(4). pii: E555. doi: 10.3390/molecules22040555.


An orally active geranyl acetophenone attenuates airway remodeling in a murine model of chronic asthma.

Lee YZ, Shaari K, Cheema MS, Tham CL, Sulaiman MR, Israf DA.

Eur J Pharmacol. 2017 Feb 15;797:53-64. doi: 10.1016/j.ejphar.2017.01.011. Epub 2017 Jan 12.


Cardamonin attenuates hyperalgesia and allodynia in a mouse model of chronic constriction injury-induced neuropathic pain: Possible involvement of the opioid system.

Sambasevam Y, Omar Farouk AA, Tengku Mohamad TA, Sulaiman MR, Bharatham BH, Perimal EK.

Eur J Pharmacol. 2017 Feb 5;796:32-38. doi: 10.1016/j.ejphar.2016.12.020. Epub 2016 Dec 15.


Cardamonin (2',4'-dihydroxy-6'-methoxychalcone) isolated from Boesenbergia rotunda (L.) Mansf. inhibits CFA-induced rheumatoid arthritis in rats.

Voon FL, Sulaiman MR, Akhtar MN, Idris MF, Akira A, Perimal EK, Israf DA, Ming-Tatt L.

Eur J Pharmacol. 2017 Jan 5;794:127-134. doi: 10.1016/j.ejphar.2016.11.009. Epub 2016 Nov 11.


Zerumbone alleviates chronic constriction injury-induced allodynia and hyperalgesia through serotonin 5-HT receptors.

Chia JSM, Omar Farouk AA, Mohamad AS, Sulaiman MR, Perimal EK.

Biomed Pharmacother. 2016 Oct;83:1303-1310. doi: 10.1016/j.biopha.2016.08.052. Epub 2016 Aug 27.


Antinociceptive Effect of 3-(2,3-Dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one in Mice Models of Induced Nociception.

Ismail NI, Ming-Tatt L, Lajis N, Akhtar MN, Akira A, Perimal EK, Israf DA, Sulaiman MR.

Molecules. 2016 Aug 22;21(8). pii: E1077. doi: 10.3390/molecules21081077.


Phytochemical Screening and Acute Oral Toxicity Study of Java Tea Leaf Extracts.

Pariyani R, Ismail IS, Azam AA, Abas F, Shaari K, Sulaiman MR.

Biomed Res Int. 2015;2015:742420. doi: 10.1155/2015/742420. Epub 2015 Dec 27.


Inhibition of Epithelial CC-Family Chemokine Synthesis by the Synthetic Chalcone DMPF-1 via Disruption of NF-κB Nuclear Translocation and Suppression of Experimental Asthma in Mice.

Rajajendram R, Tham CL, Akhtar MN, Sulaiman MR, Israf DA.

Mediators Inflamm. 2015;2015:176926. doi: 10.1155/2015/176926. Epub 2015 Aug 2.


Antiallodynic and antihyperalgesic effects of zerumbone on a mouse model of chronic constriction injury-induced neuropathic pain.

Zulazmi NA, Gopalsamy B, Farouk AA, Sulaiman MR, Bharatham BH, Perimal EK.

Fitoterapia. 2015 Sep;105:215-21. doi: 10.1016/j.fitote.2015.07.011. Epub 2015 Jul 20.


Interferon-Gamma Increases Endothelial Permeability by Causing Activation of p38 MAP Kinase and Actin Cytoskeleton Alteration.

Ng CT, Fong LY, Sulaiman MR, Moklas MA, Yong YK, Hakim MN, Ahmad Z.

J Interferon Cytokine Res. 2015 Jul;35(7):513-22. doi: 10.1089/jir.2014.0188. Epub 2015 Apr 1.


The synthetic curcuminoid BHMC restores endotoxin-stimulated HUVEC dysfunction:Specific disruption on enzymatic activity of p38 MAPK.

Tham CL, Hazeera Harith H, Wai Lam K, Joong Chong Y, Singh Cheema M, Roslan Sulaiman M, Hj Lajis N, Ahmad Israf D.

Eur J Pharmacol. 2015 Feb 15;749:1-11. doi: 10.1016/j.ejphar.2014.12.015. Epub 2015 Jan 3.


Flavokawain A induces apoptosis in MCF-7 and MDA-MB231 and inhibits the metastatic process in vitro.

Abu N, Akhtar MN, Yeap SK, Lim KL, Ho WY, Zulfadli AJ, Omar AR, Sulaiman MR, Abdullah MP, Alitheen NB.

PLoS One. 2014 Oct 6;9(10):e105244. doi: 10.1371/journal.pone.0105244. eCollection 2014.


Anti-hyperalgesic effect of a benzilidine-cyclohexanone analogue on a mouse model of chronic constriction injury-induced neuropathic pain: Participation of the κ-opioid receptor and KATP.

Ming-Tatt L, Khalivulla SI, Akhtar MN, Lajis N, Perimal EK, Akira A, Ali DI, Sulaiman MR.

Pharmacol Biochem Behav. 2013 Dec;114-115:58-63. doi: 10.1016/j.pbb.2013.10.019. Epub 2013 Nov 4.


Peripheral antinociception of a chalcone, flavokawin B and possible involvement of the nitric oxide/cyclic guanosine monophosphate/potassium channels pathway.

Kamaldin MN, Akhtar MN, Mohamad AS, Lajis N, Perimal EK, Akira A, Ming-Tatt L, Israf DA, Sulaiman MR.

Molecules. 2013 Apr 10;18(4):4209-20. doi: 10.3390/molecules18044209.


Cytoprotective and enhanced anti-inflammatory activities of liposomal piroxicam formulation in lipopolysaccharide-stimulated RAW 264.7 macrophages.

Chiong HS, Yong YK, Ahmad Z, Sulaiman MR, Zakaria ZA, Yuen KH, Hakim MN.

Int J Nanomedicine. 2013;8:1245-55. doi: 10.2147/IJN.S42801. Epub 2013 Mar 22.


Development and validation of a bioanalytical method for quantification of 2,6-bis-(4-hydroxy-3-methoxybenzylidene)-cyclohexanone (BHMC) in rat plasma.

Lee YZ, Ming-Tatt L, Lajis NH, Sulaiman MR, Israf DA, Tham CL.

Molecules. 2012 Dec 7;17(12):14555-64. doi: 10.3390/molecules171214555.

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