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Items: 1 to 20 of 28

1.

Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease.

Purgatorio R, de Candia M, Catto M, Carrieri A, Pisani L, De Palma A, Toma M, Ivanova OA, Voskressensky LG, Altomare CD.

Eur J Med Chem. 2019 Sep 1;177:414-424. doi: 10.1016/j.ejmech.2019.05.062. Epub 2019 May 28.

PMID:
31158754
2.

Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity.

Purgatorio R, de Candia M, De Palma A, De Santis F, Pisani L, Campagna F, Cellamare S, Altomare CD, Catto M.

Molecules. 2018 Jun 26;23(7). pii: E1544. doi: 10.3390/molecules23071544.

3.

A New Class of 1-Aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline Derivatives as Reversers of P-Glycoprotein-Mediated Multidrug Resistance in Tumor Cells.

Nevskaya AA, Matveeva MD, Borisova TN, Niso M, Colabufo NA, Boccarelli A, Purgatorio R, de Candia M, Cellamare S, Voskressensky LG, Altomare CD.

ChemMedChem. 2018 Aug 10;13(15):1588-1596. doi: 10.1002/cmdc.201800177. Epub 2018 Jul 4.

PMID:
29802687
4.

Delivery of Proapoptotic Agents in Glioma Cell Lines by TSPO Ligand-Dextran Nanogels.

Lopalco A, Cutrignelli A, Denora N, Perrone M, Iacobazzi RM, Fanizza E, Lopedota A, Depalo N, de Candia M, Franco M, Laquintana V.

Int J Mol Sci. 2018 Apr 11;19(4). pii: E1155. doi: 10.3390/ijms19041155.

5.

Structure-property relationship study of the HPLC enantioselective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase.

Pisani L, Rullo M, Catto M, de Candia M, Carrieri A, Cellamare S, Altomare CD.

J Sep Sci. 2018 Mar;41(6):1376-1384. doi: 10.1002/jssc.201701442.

PMID:
29419937
6.

The position of fluorine in CP-118,954 affects AChE inhibition potency and PET imaging quantification for AChE expression in the rat brain.

Lee BC, Moon BS, Park HS, Jung JH, Park HS, Park DD, de Candia M, Denora N, Altomare CD, Kim SE.

Eur J Pharm Sci. 2017 Nov 15;109:209-216. doi: 10.1016/j.ejps.2017.08.008. Epub 2017 Aug 15.

PMID:
28818531
7.

Oxazepam-Dopamine Conjugates Increase Dopamine Delivery into Striatum of Intact Rats.

Cassano T, Lopalco A, de Candia M, Laquintana V, Lopedota A, Cutrignelli A, Perrone M, Iacobazzi RM, Bedse G, Franco M, Denora N, Altomare CD.

Mol Pharm. 2017 Sep 5;14(9):3178-3187. doi: 10.1021/acs.molpharmaceut.7b00405. Epub 2017 Aug 22.

PMID:
28780872
8.

Investigating Structural Requirements for the Antiproliferative Activity of Biphenyl Nicotinamides.

Majellaro M, Stefanachi A, Tardia P, Vicenti C, Boccarelli A, Pannunzio A, Campanella F, Coluccia M, Denora N, Leonetti F, de Candia M, Altomare CD, Cellamare S.

ChemMedChem. 2017 Aug 22;12(16):1380-1389. doi: 10.1002/cmdc.201700365. Epub 2017 Aug 3.

PMID:
28665505
9.

A greener and efficient access to substituted four- and six-membered sulfur-bearing heterocycles.

Parisi G, Degennaro L, Carlucci C, de Candia M, Mastrorilli P, Roller A, Holzer W, Altomare CD, Pace V, Luisi R.

Org Biomol Chem. 2017 Jun 14;15(23):5000-5015. doi: 10.1039/c7ob00846e.

PMID:
28567461
10.

Pharmaceutical development of novel lactate-based 6-fluoro-l-DOPA formulations.

Denora N, Lopedota A, de Candia M, Cellamare S, Degennaro L, Luisi R, Mele A, Tricarico D, Cutrignelli A, Laquintana V, Altomare CD, Franco M, Dimiccoli V, Tolomeo A, Scilimati A.

Eur J Pharm Sci. 2017 Mar 1;99:361-368. doi: 10.1016/j.ejps.2016.10.001. Epub 2016 Oct 4.

PMID:
27717874
11.

New azepino[4,3-b]indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effects against NMDA-induced neurotoxicity.

de Candia M, Zaetta G, Denora N, Tricarico D, Majellaro M, Cellamare S, Altomare CD.

Eur J Med Chem. 2017 Jan 5;125:288-298. doi: 10.1016/j.ejmech.2016.09.037. Epub 2016 Sep 13.

PMID:
27688184
12.

Galloyl benzamide-based compounds modulating tumour necrosis factor α-stimulated c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signalling pathways.

Leo V, Stefanachi A, Nacci C, Leonetti F, de Candia M, Carotti A, Altomare CD, Montagnani M, Cellamare S.

J Pharm Pharmacol. 2015 Oct;67(10):1380-92. doi: 10.1111/jphp.12438. Epub 2015 Jun 16.

PMID:
26078032
13.

New organic nitrate-containing benzyloxy isonipecotanilide derivatives with vasodilatory and anti-platelet activity.

de Candia M, Marini E, Zaetta G, Cellamare S, Di Stilo A, Altomare CD.

Eur J Pharm Sci. 2015 May 25;72:69-80. doi: 10.1016/j.ejps.2015.03.004. Epub 2015 Mar 10.

14.

How a β-D-glucoside side chain enhances binding affinity to thrombin of inhibitors bearing 2-chlorothiophene as P1 moiety: crystallography, fragment deconstruction study, and evaluation of antithrombotic properties.

Belviso BD, Caliandro R, de Candia M, Zaetta G, Lopopolo G, Incampo F, Colucci M, Altomare CD.

J Med Chem. 2014 Oct 23;57(20):8563-75. doi: 10.1021/jm5010754. Epub 2014 Oct 14.

PMID:
25268757
15.

Synthesis and biological evaluation of direct thrombin inhibitors bearing 4-(piperidin-1-yl)pyridine at the P1 position with potent anticoagulant activity.

de Candia M, Fiorella F, Lopopolo G, Carotti A, Romano MR, Lograno MD, Martel S, Carrupt PA, Belviso BD, Caliandro R, Altomare C.

J Med Chem. 2013 Nov 14;56(21):8696-711. doi: 10.1021/jm401169a. Epub 2013 Oct 22.

PMID:
24102612
16.

Targeting of the translocator protein 18 kDa (TSPO): a valuable approach for nuclear and optical imaging of activated microglia.

Trapani A, Palazzo C, de Candia M, Lasorsa FM, Trapani G.

Bioconjug Chem. 2013 Sep 18;24(9):1415-28. doi: 10.1021/bc300666f. Epub 2013 Jul 23. Review.

PMID:
23837837
17.

Protein crystallography and fragment-based drug design.

Caliandro R, Belviso DB, Aresta BM, de Candia M, Altomare CD.

Future Med Chem. 2013 Jun;5(10):1121-40. doi: 10.4155/fmc.13.84. Review.

PMID:
23795969
18.

β-D-glucosyl conjugates of highly potent inhibitors of blood coagulation factor Xa bearing 2-chorothiophene as a P1 motif.

Lopopolo G, de Candia M, Panza L, Romano MR, Lograno MD, Campagna F, Altomare C.

ChemMedChem. 2012 Sep;7(9):1669-77. doi: 10.1002/cmdc.201200224. Epub 2012 Jul 31.

PMID:
22851501
19.

2-Benzazepine nitrones protect dopaminergic neurons against 6-hydroxydopamine-induced oxidative toxicity.

Soto-Otero R, Méndez-Álvarez E, Sánchez-Iglesias S, Labandeira-García JL, Rodríguez-Pallares J, Zubkov FI, Zaytsev VP, Voskressensky LG, Varlamov AV, de Candia M, Fiorella F, Altomare C.

Arch Pharm (Weinheim). 2012 Aug;345(8):598-609. doi: 10.1002/ardp.201200007. Epub 2012 Apr 25.

PMID:
22532340
20.

Biarylmethoxy isonipecotanilides as potent and selective inhibitors of blood coagulation factor Xa.

Lopopolo G, Fiorella F, de Candia M, Nicolotti O, Martel S, Carrupt PA, Altomare C.

Eur J Pharm Sci. 2011 Feb 14;42(3):180-91. doi: 10.1016/j.ejps.2010.11.010. Epub 2010 Nov 26.

PMID:
21112391

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