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Items: 1 to 20 of 37

1.

Synthesis of 3-(Imidazo[2,1-b]thiazol-6-yl)-2H-chromen-2-one Derivatives and Study of Their Antiviral Activity against Parvovirus B19.

Conti I, Morigi R, Locatelli A, Rambaldi M, Bua G, Gallinella G, Leoni A.

Molecules. 2019 Mar 15;24(6). pii: E1037. doi: 10.3390/molecules24061037.

2.

Synthesis, in vitro and in vivo biological evaluation of substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones as new potent anticancer agents.

Morigi R, Locatelli A, Leoni A, Rambaldi M, Bortolozzi R, Mattiuzzo E, Ronca R, Maccarinelli F, Hamel E, Bai R, Brancale A, Viola G.

Eur J Med Chem. 2019 Mar 15;166:514-530. doi: 10.1016/j.ejmech.2019.01.049. Epub 2019 Jan 26.

PMID:
30784885
3.

Investigation on the Effects of Antimicrobial imidazo[2,1-b]thiazole Derivatives on the Genitourinary Microflora.

Morigi R, Vitali B, Prata C, Palomino RAN, Graziadio A, Locatelli A, Rambaldi M, Leoni A.

Med Chem. 2018;14(3):311-319. doi: 10.2174/1573406413666171010110819.

PMID:
29032761
4.

Small-Molecules Targeting Kinases Involved in Pulmonary Hypertension: a Patent Review (2010-2015).

Morigi R, Rambaldi M, Locatelli A, Leoni A.

Curr Med Chem. 2016;23(30):3510-3527. Review.

PMID:
27516199
5.

Toward the Development of Specific G-Quadruplex Binders: Synthesis, Biophysical, and Biological Studies of New Hydrazone Derivatives.

Amato J, Morigi R, Pagano B, Pagano A, Ohnmacht S, De Magis A, Tiang YP, Capranico G, Locatelli A, Graziadio A, Leoni A, Rambaldi M, Novellino E, Neidle S, Randazzo A.

J Med Chem. 2016 Jun 23;59(12):5706-20. doi: 10.1021/acs.jmedchem.6b00129. Epub 2016 Jun 6.

PMID:
27223049
6.

2-Indolinone a versatile scaffold for treatment of cancer: a patent review (2008-2014).

Leoni A, Locatelli A, Morigi R, Rambaldi M.

Expert Opin Ther Pat. 2016;26(2):149-73. doi: 10.1517/13543776.2016.1118059. Epub 2015 Dec 4. Review.

PMID:
26561198
7.

Recent Patents on Thiazole Derivatives Endowed with Antitumor Activity.

Morigi R, Locatelli A, Leoni A, Rambaldi M.

Recent Pat Anticancer Drug Discov. 2015;10(3):280-97. Review.

PMID:
26152151
8.

Synthesis and antiproliferative activity of imidazo[2,1-b][1,3,4]thiadiazole derivatives.

Kumar S, Gopalakrishnan V, Hegde M, Rana V, Dhepe SS, Ramareddy SA, Leoni A, Locatelli A, Morigi R, Rambaldi M, Srivastava M, Raghavan SC, Karki SS.

Bioorg Med Chem Lett. 2014 Oct 1;24(19):4682-4688. doi: 10.1016/j.bmcl.2014.08.032. Epub 2014 Aug 26.

PMID:
25205189
9.

Bis-indole derivatives with antitumor activity turn out to be specific ligands of human telomeric G-quadruplex.

Amato J, Iaccarino N, Pagano B, Morigi R, Locatelli A, Leoni A, Rambaldi M, Zizza P, Biroccio A, Novellino E, Randazzo A.

Front Chem. 2014 Jul 24;2:54. doi: 10.3389/fchem.2014.00054. eCollection 2014.

10.

Substituted E-3-(3-indolylmethylene)1,3-dihydroindol-2-ones with antiproliferative activity. Study of the effects on HL-60 leukemia cells.

Leoni A, Locatelli A, Morigi R, Rambaldi M, Cappadone C, Farruggia G, Iotti S, Merolle L, Zini M, Stefanelli C.

Eur J Med Chem. 2014 May 22;79:382-90. doi: 10.1016/j.ejmech.2014.04.004. Epub 2014 Apr 3.

PMID:
24747749
11.

Novel thiazole derivatives: a patent review (2008 - 2012. Part 2).

Leoni A, Locatelli A, Morigi R, Rambaldi M.

Expert Opin Ther Pat. 2014 Jul;24(7):759-77. doi: 10.1517/13543776.2014.910196. Epub 2014 Apr 19. Review.

PMID:
24745553
12.

Novel thiazole derivatives: a patent review (2008 - 2012; Part 1).

Leoni A, Locatelli A, Morigi R, Rambaldi M.

Expert Opin Ther Pat. 2014 Feb;24(2):201-16. doi: 10.1517/13543776.2014.858121. Epub 2013 Nov 12. Review.

PMID:
24215328
13.

Chemopreventive and antioxidant activity of 6-substituted imidazo[2,1-b]thiazoles.

Andreani A, Leoni A, Locatelli A, Morigi R, Rambaldi M, Cervellati R, Greco E, Kondratyuk TP, Park EJ, Huang K, van Breemen RB, Pezzuto JM.

Eur J Med Chem. 2013 Oct;68:412-21. doi: 10.1016/j.ejmech.2013.07.052. Epub 2013 Aug 13.

PMID:
23994869
14.

Cytotoxic activities of substituted 3-(3,4,5-trimethoxybenzylidene)-1,3-dihydroindol-2-ones and studies on their mechanisms of action.

Andreani A, Granaiola M, Locatelli A, Morigi R, Rambaldi M, Varoli L, Vieceli Dalla Sega F, Prata C, Nguyen TL, Bai R, Hamel E.

Eur J Med Chem. 2013 Jun;64:603-12. doi: 10.1016/j.ejmech.2013.03.033. Epub 2013 Apr 3.

15.

Substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones and analogues: synthesis, cytotoxic activity, and study of the mechanism of action.

Andreani A, Granaiola M, Locatelli A, Morigi R, Rambaldi M, Varoli L, Calonghi N, Cappadone C, Farruggia G, Stefanelli C, Masotti L, Nguyen TL, Hamel E, Shoemaker RH.

J Med Chem. 2012 Mar 8;55(5):2078-88. doi: 10.1021/jm2012694. Epub 2012 Feb 15.

16.

Imidazo[2,1-b]thiazole guanylhydrazones as RSK2 inhibitors.

Andreani A, Granaiola M, Leoni A, Locatelli A, Morigi R, Rambaldi M, Varoli L, Lannigan D, Smith J, Scudiero D, Kondapaka S, Shoemaker RH.

Eur J Med Chem. 2011 Sep;46(9):4311-23. doi: 10.1016/j.ejmech.2011.07.001. Epub 2011 Jul 8.

PMID:
21794960
17.

Substituted E-3-(3-indolylmethylene)-1,3-dihydroindol-2-ones with antitumor activity. In depth study of the effect on growth of breast cancer cells.

Andreani A, Bellini S, Burnelli S, Granaiola M, Leoni A, Locatelli A, Morigi R, Rambaldi M, Varoli L, Calonghi N, Cappadone C, Zini M, Stefanelli C, Masotti L, Shoemaker RH.

J Med Chem. 2010 Aug 12;53(15):5567-75. doi: 10.1021/jm1007165.

18.

Bis-guanylhydrazone diimidazo[1,2-a:1,2-c]pyrimidine as a novel and specific G-quadruplex binding motif.

Sparapani S, Bellini S, Gunaratnam M, Haider SM, Andreani A, Rambaldi M, Locatelli A, Morigi R, Granaiola M, Varoli L, Burnelli S, Leoni A, Neidle S.

Chem Commun (Camb). 2010 Aug 21;46(31):5680-2. doi: 10.1039/c0cc00020e. Epub 2010 Jun 28.

PMID:
20582382
19.

Antitumor activity and COMPARE analysis of bis-indole derivatives.

Andreani A, Burnelli S, Granaiola M, Leoni A, Locatelli A, Morigi R, Rambaldi M, Varoli L, Landi L, Prata C, Dalla Sega FV, Caliceti C, Shoemaker RH.

Bioorg Med Chem. 2010 May 1;18(9):3004-11. doi: 10.1016/j.bmc.2010.03.063. Epub 2010 Mar 28.

PMID:
20395150
20.

New isatin derivatives with antioxidant activity.

Andreani A, Burnelli S, Granaiola M, Leoni A, Locatelli A, Morigi R, Rambaldi M, Varoli L, Cremonini MA, Placucci G, Cervellati R, Greco E.

Eur J Med Chem. 2010 Apr;45(4):1374-8. doi: 10.1016/j.ejmech.2009.12.035. Epub 2009 Dec 28.

PMID:
20060202

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