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Items: 1 to 20 of 52


Identification of a Novel Deactivating Small-Molecule Compound for Fibrogenic Hepatic Stellate Cells.

Sakaguchi T, Kono Y, Itaba N, Morimoto M, Isomoto H, Shiota G.

Yonago Acta Med. 2020 Feb 20;63(1):79-87. doi: 10.33160/yam.2020.02.013. eCollection 2020 Feb.


WNT/β-catenin signal inhibitor IC-2-derived small-molecule compounds suppress TGF-β1-induced fibrogenic response of renal epithelial cells by inhibiting SMAD2/3 signalling.

Hoi S, Tsuchiya H, Itaba N, Suzuki K, Oka H, Morimoto M, Takata T, Isomoto H, Shiota G.

Clin Exp Pharmacol Physiol. 2020 Feb 3. doi: 10.1111/1440-1681.13270. [Epub ahead of print]


Reversal of established liver fibrosis by IC-2-engineered mesenchymal stem cell sheets.

Itaba N, Kono Y, Watanabe K, Yokobata T, Oka H, Osaki M, Kakuta H, Morimoto M, Shiota G.

Sci Rep. 2019 May 2;9(1):6841. doi: 10.1038/s41598-019-43298-0.


Hair growth-promoting activities of chitosan and surface-deacetylated chitin nanofibers.

Azuma K, Koizumi R, Izawa H, Morimoto M, Saimoto H, Osaki T, Ito N, Yamashita M, Tsuka T, Imagawa T, Okamoto Y, Inoue T, Ifuku S.

Int J Biol Macromol. 2019 Apr 1;126:11-17. doi: 10.1016/j.ijbiomac.2018.12.135. Epub 2018 Dec 18.


Guanidinylated chitosan inspired by arginine-rich cell-penetrating peptides.

Izawa H, Kinai M, Ifuku S, Morimoto M, Saimoto H.

Int J Biol Macromol. 2019 Mar 15;125:901-905. doi: 10.1016/j.ijbiomac.2018.12.138. Epub 2018 Dec 17.


Hepatic cell sheets engineered from human mesenchymal stem cells with a single small molecule compound IC-2 ameliorate acute liver injury in mice.

Itaba N, Noda I, Oka H, Kono Y, Okinaka K, Yokobata T, Okazaki S, Morimoto M, Shiota G.

Regen Ther. 2018 Aug 24;9:45-57. doi: 10.1016/j.reth.2018.07.001. eCollection 2018 Dec.


Retraction: Azuma, K. et al. Chitin, Chitosan, and Its Derivatives for Wound Healing: Old and New Materials. J. Funct. Biomater. 2015, 6, 104⁻142.

Azuma K, Izumi R, Osaki T, Ifuku S, Morimoto M, Saimoto H, Minami S, Okamoto Y; Journal of Functional Biomaterials Editorial Office.

J Funct Biomater. 2018 Jun 7;9(2). pii: E38. doi: 10.3390/jfb9020038.


Wood-mimetic skins prepared using horseradish peroxidase catalysis to induce surface wrinkling of chitosan film upon drying.

Izawa H, Dote Y, Okuda N, Sumita M, Ifuku S, Morimoto M, Saimoto H.

Carbohydr Polym. 2017 Oct 1;173:519-525. doi: 10.1016/j.carbpol.2017.06.034. Epub 2017 Jun 9.


A Novel Small-molecule WNT Inhibitor, IC-2, Has the Potential to Suppress Liver Cancer Stem Cells.

Seto K, Sakabe T, Itaba N, Azumi J, Oka H, Morimoto M, Umekita Y, Shiota G.

Anticancer Res. 2017 Jul;37(7):3569-3579.


Preparation and biocompatibility of a chitin nanofiber/gelatin composite film.

Ogawa Y, Azuma K, Izawa H, Morimoto M, Ochi K, Osaki T, Ito N, Okamoto Y, Saimoto H, Ifuku S.

Int J Biol Macromol. 2017 Nov;104(Pt B):1882-1889. doi: 10.1016/j.ijbiomac.2017.02.041. Epub 2017 Feb 16.


Oral Administration of Surface-Deacetylated Chitin Nanofibers and Chitosan Inhibit 5-Fluorouracil-Induced Intestinal Mucositis in Mice.

Koizumi R, Azuma K, Izawa H, Morimoto M, Ochi K, Tsuka T, Imagawa T, Osaki T, Ito N, Okamoto Y, Saimoto H, Ifuku S.

Int J Mol Sci. 2017 Jan 27;18(2). pii: E279. doi: 10.3390/ijms18020279.


Biobased Wrinkled Surfaces Induced by Wood Mimetic Skins upon Drying: Effect of Mechanical Properties on Wrinkle Morphology.

Izawa H, Okuda N, Moriyama A, Miyazaki Y, Ifuku S, Morimoto M, Saimoto H.

Langmuir. 2016 Dec 6;32(48):12799-12804. Epub 2016 Nov 16.


Protein/CaCO₃/Chitin Nanofiber Complex Prepared from Crab Shells by Simple Mechanical Treatment and Its Effect on Plant Growth.

Aklog YF, Egusa M, Kaminaka H, Izawa H, Morimoto M, Saimoto H, Ifuku S.

Int J Mol Sci. 2016 Sep 22;17(10). pii: E1600. doi: 10.3390/ijms17101600.


Preparation of chitin nanofibers by surface esterification of chitin with maleic anhydride and mechanical treatment.

Aklog YF, Nagae T, Izawa H, Morimoto M, Saimoto H, Ifuku S.

Carbohydr Polym. 2016 Nov 20;153:55-59. doi: 10.1016/j.carbpol.2016.07.060. Epub 2016 Jul 19.


Wnt/Beta-Catenin Signal Inhibitor HC-1 Sensitizes Oral Squamous Cell Carcinoma Cells to 5-Fluorouracil through Reduction of CD44-Positive Population.

Yokogi S, Tsubota T, Kanki K, Azumi J, Itaba N, Oka H, Morimoto M, Ryoke K, Shiota G.

Yonago Acta Med. 2016 Jun 29;59(2):93-9. eCollection 2016 Jun.


Chitin nanofibrils suppress skin inflammation in atopic dermatitis-like skin lesions in NC/Nga mice.

Izumi R, Azuma K, Izawa H, Morimoto M, Nagashima M, Osaki T, Tsuka T, Imagawa T, Ito N, Okamoto Y, Saimoto H, Ifuku S.

Carbohydr Polym. 2016 Aug 1;146:320-7. doi: 10.1016/j.carbpol.2016.03.068. Epub 2016 Mar 25.


Identification of the small molecule compound which induces hepatic differentiation of human mesenchymal stem cells.

Itaba N, Sakabe T, Kanki K, Azumi J, Shimizu H, Kono Y, Matsumi Y, Abe KI, Tonoi T, Oka H, Sakurai T, Saimoto H, Morimoto M, Mabuchi Y, Matsuzaki Y, Shiota G.

Regen Ther. 2015 Nov 26;2:32-41. doi: 10.1016/j.reth.2015.10.001. eCollection 2015 Dec.


Biomineralization of calcium phosphate crystals on chitin nanofiber hydrogel for bone regeneration material.

Kawata M, Azuma K, Izawa H, Morimoto M, Saimoto H, Ifuku S.

Carbohydr Polym. 2016 Jan 20;136:964-9. doi: 10.1016/j.carbpol.2015.10.009. Epub 2015 Oct 9.


Human mesenchymal stem cell-engineered hepatic cell sheets accelerate liver regeneration in mice.

Itaba N, Matsumi Y, Okinaka K, Ashla AA, Kono Y, Osaki M, Morimoto M, Sugiyama N, Ohashi K, Okano T, Shiota G.

Sci Rep. 2015 Nov 10;5:16169. doi: 10.1038/srep16169.

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