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Items: 1 to 20 of 27


Cephamycins inhibit pathogen sporulation and effectively treat recurrent Clostridioides difficile infection.

Srikhanta YN, Hutton ML, Awad MM, Drinkwater N, Singleton J, Day SL, Cunningham BA, McGowan S, Lyras D.

Nat Microbiol. 2019 Aug 12. doi: 10.1038/s41564-019-0519-1. [Epub ahead of print]


Tranexamic Acid Influences the Immune Response, but not Bacterial Clearance in a Model of Post-Traumatic Brain Injury Pneumonia.

Draxler DF, Awad MM, Hanafi G, Daglas M, Ho H, Keragala C, Galle A, Roquilly A, Lyras D, Sashindranath M, Medcalf RL.

J Neurotrauma. 2019 Aug 2. doi: 10.1089/neu.2018.6030. [Epub ahead of print]


pCP13, a representative of a new family of conjugative toxin plasmids in Clostridium perfringens.

Watts TD, Vidor CJ, Awad MM, Lyras D, Rood JI, Adams V.

Plasmid. 2019 Mar;102:37-45. doi: 10.1016/j.plasmid.2019.02.002. Epub 2019 Feb 18.


Lectin Activity of the TcdA and TcdB Toxins of Clostridium difficile.

Hartley-Tassell LE, Awad MM, Seib KL, Scarselli M, Savino S, Tiralongo J, Lyras D, Day CJ, Jennings MP.

Infect Immun. 2019 Feb 21;87(3). pii: e00676-18. doi: 10.1128/IAI.00676-18. Print 2019 Mar.


The NEAT Domain-Containing Proteins of Clostridium perfringens Bind Heme.

Choo JM, Cheung JK, Wisniewski JA, Steer DL, Bulach DM, Hiscox TJ, Chakravorty A, Smith AI, Gell DA, Rood JI, Awad MM.

PLoS One. 2016 Sep 16;11(9):e0162981. doi: 10.1371/journal.pone.0162981. eCollection 2016.


The Sialidase NanS Enhances Non-TcsL Mediated Cytotoxicity of Clostridium sordellii.

Awad MM, Singleton J, Lyras D.

Toxins (Basel). 2016 Jun 17;8(6). pii: E189. doi: 10.3390/toxins8060189.


Functional analysis of an feoB mutant in Clostridium perfringens strain 13.

Awad MM, Cheung JK, Tan JE, McEwan AG, Lyras D, Rood JI.

Anaerobe. 2016 Oct;41:10-17. doi: 10.1016/j.anaerobe.2016.05.005. Epub 2016 May 10.


Disruption of the Gut Microbiome: Clostridium difficile Infection and the Threat of Antibiotic Resistance.

Johanesen PA, Mackin KE, Hutton ML, Awad MM, Larcombe S, Amy JM, Lyras D.

Genes (Basel). 2015 Dec 21;6(4):1347-60. doi: 10.3390/genes6041347. Review.


The pore-forming α-toxin from clostridium septicum activates the MAPK pathway in a Ras-c-Raf-dependent and independent manner.

Chakravorty A, Awad MM, Cheung JK, Hiscox TJ, Lyras D, Rood JI.

Toxins (Basel). 2015 Feb 10;7(2):516-34. doi: 10.3390/toxins7020516.


Clostridium difficile virulence factors: Insights into an anaerobic spore-forming pathogen.

Awad MM, Johanesen PA, Carter GP, Rose E, Lyras D.

Gut Microbes. 2014;5(5):579-93. doi: 10.4161/19490976.2014.969632. Review.


Comparing the identification of Clostridium spp. by two Matrix-Assisted Laser Desorption Ionization-Time of Flight (MALDI-TOF) mass spectrometry platforms to 16S rRNA PCR sequencing as a reference standard: a detailed analysis of age of culture and sample preparation.

Chean R, Kotsanas D, Francis MJ, Palombo EA, Jadhav SR, Awad MM, Lyras D, Korman TM, Jenkin GA.

Anaerobe. 2014 Dec;30:85-9. doi: 10.1016/j.anaerobe.2014.09.007. Epub 2014 Sep 16.


Expression of the large clostridial toxins is controlled by conserved regulatory mechanisms.

Carter GP, Larcombe S, Li L, Jayawardena D, Awad MM, Songer JG, Lyras D.

Int J Med Microbiol. 2014 Nov;304(8):1147-59. doi: 10.1016/j.ijmm.2014.08.008. Epub 2014 Aug 18.


Towards an understanding of the role of Clostridium perfringens toxins in human and animal disease.

Uzal FA, Freedman JC, Shrestha A, Theoret JR, Garcia J, Awad MM, Adams V, Moore RJ, Rood JI, McClane BA.

Future Microbiol. 2014;9(3):361-77. doi: 10.2217/fmb.13.168. Review.


Utility of the clostridial site-specific recombinase TnpX to clone toxic-product-encoding genes and selectively remove genomic DNA fragments.

Adams V, Bantwal R, Stevenson L, Cheung JK, Awad MM, Nicholson J, Carter GP, Mackin KE, Rood JI, Lyras D.

Appl Environ Microbiol. 2014 Jun;80(12):3597-3603.


Opioid analgesics stop the development of clostridial gas gangrene.

Chakravorty A, Awad MM, Hiscox TJ, Cheung JK, Choo JM, Lyras D, Rood JI.

J Infect Dis. 2014 Aug 1;210(3):483-92. doi: 10.1093/infdis/jiu101. Epub 2014 Feb 18.


The cysteine protease α-clostripain is not essential for the pathogenesis of Clostridium perfringens-mediated myonecrosis.

Chakravorty A, Awad MM, Hiscox TJ, Cheung JK, Carter GP, Choo JM, Lyras D, Rood JI.

PLoS One. 2011;6(7):e22762. doi: 10.1371/journal.pone.0022762. Epub 2011 Jul 29.


TcdB or not TcdB: a tale of two Clostridium difficile toxins.

Carter GP, Awad MM, Kelly ML, Rood JI, Lyras D.

Future Microbiol. 2011 Feb;6(2):121-3. doi: 10.2217/fmb.10.169. No abstract available.


TcsL is an essential virulence factor in Clostridium sordellii ATCC 9714.

Carter GP, Awad MM, Hao Y, Thelen T, Bergin IL, Howarth PM, Seemann T, Rood JI, Aronoff DM, Lyras D.

Infect Immun. 2011 Mar;79(3):1025-32. doi: 10.1128/IAI.00968-10. Epub 2011 Jan 3.


Novel use of tryptose sulfite cycloserine egg yolk agar for isolation of Clostridium perfringens during an outbreak of necrotizing enterocolitis in a neonatal unit.

Kotsanas D, Carson JA, Awad MM, Lyras D, Rood JI, Jenkin GA, Stuart RL, Korman TM.

J Clin Microbiol. 2010 Nov;48(11):4263-5. doi: 10.1128/JCM.01724-10. Epub 2010 Sep 8.


The NanI and NanJ sialidases of Clostridium perfringens are not essential for virulence.

Chiarezza M, Lyras D, Pidot SJ, Flores-Díaz M, Awad MM, Kennedy CL, Cordner LM, Phumoonna T, Poon R, Hughes ML, Emmins JJ, Alape-Girón A, Rood JI.

Infect Immun. 2009 Oct;77(10):4421-8. doi: 10.1128/IAI.00548-09. Epub 2009 Aug 3.

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