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Diagnostics (Basel). 2019 Jun 30;9(3). pii: E68. doi: 10.3390/diagnostics9030068.

Anatomy and Imaging of Rat Prostate: Practical Monitoring in Experimental Cancer-Induced Protocols.

Author information

1
Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro (UTAD), 5001-801 Vila Real, Portugal.
2
Center for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), 5001-801 Vila Real, Portugal.
3
Department of Medicine, Surgery and Veterinary Anatomy, University of León, 24071 León, Spain.
4
Animal and Veterinary Research Center (CECAV), 5001-801 Vila Real, Portugal.
5
Organic Chemistry, Natural Products and Food Stuffs (QOPNA), 3810-193 Aveiro, Portugal.
6
Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal.
7
Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro (UTAD), 5001-801 Vila Real, Portugal. pamo@utad.pt.
8
Center for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), 5001-801 Vila Real, Portugal. pamo@utad.pt.
9
Faculty of Veterinary Medicine, Lusophone University of Humanities and Technologies (ULHT), 1749-024 Lisbon, Portugal.

Abstract

The rat has been frequently used as a model to study several human diseases, including cancer. In many research protocols using cancer models, researchers find it difficult to perform several of the most commonly used techniques and to compare their results. Although the protocols for the study of carcinogenesis are based on the macroscopic and microscopic anatomy of organs, few studies focus on the use of imaging. The use of imaging modalities to monitor the development of cancer avoids the need for intermediate sacrifice to assess the status of induced lesions, thus reducing the number of animals used in experiments. Our work intends to provide a complete and systematic overview of rat prostate anatomy and imaging, facilitating the monitoring of prostate cancer development through different imaging modalities, such as ultrasonography, computed tomography (CT) and magnetic resonance imaging (MRI).

KEYWORDS:

computed tomography (CT); macroscopy; magnetic resonance imaging (MRI); microscopy; ultrasonography

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