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Antitumor agents 7. Synthesis, antiproliferative activity and molecular modeling of new l-lysine-conjugated pyridophenoxazinones as potent DNA-binding ligands and topoisomerase IIα inhibitors.

Pedatella S, Cerchia C, Manfra M, Cioce A, Bolognese A, Lavecchia A.

Eur J Med Chem. 2020 Feb 1;187:111960. doi: 10.1016/j.ejmech.2019.111960. Epub 2019 Dec 14.


Anti-Inflammatory and Antioxidant Properties of Dehydrated Potato-Derived Bioactive Compounds in Intestinal Cells.

Basilicata MG, Pepe G, Rapa SF, Merciai F, Ostacolo C, Manfra M, Di Sarno V, Autore G, De Vita D, Marzocco S, Campiglia P.

Int J Mol Sci. 2019 Dec 3;20(23). pii: E6087. doi: 10.3390/ijms20236087.


Synthesis and Pharmacological Characterization of Conformationally Restricted Retigabine Analogues as Novel Neuronal Kv7 Channel Activators.

Ostacolo C, Miceli F, Di Sarno V, Nappi P, Iraci N, Soldovieri MV, Ciaglia T, Ambrosino P, Vestuto V, Lauritano A, Musella S, Pepe G, Basilicata MG, Manfra M, Perinelli DR, Novellino E, Bertamino A, Gomez-Monterrey IM, Campiglia P, Taglialatela M.

J Med Chem. 2020 Jan 9;63(1):163-185. doi: 10.1021/acs.jmedchem.9b00796. Epub 2019 Dec 24.


An 1H NMR study of the cytarabine degradation in clinical conditions to avoid drug waste, decrease therapy costs and improve patient compliance in acute leukemia.

Cerchione C, Martinelli G, Pedatella S, De Nisco M, Pugliese N, Manfra M, Marra N, Ronconi S, De Giorgi U, Altini M, Simonetti G, Di Rorà AGL, Bravaccini S, Catalano L, Dora Iula V, Pagano F, Picardi M, Bolognese A, Pane F, Martinelli V.

Anticancer Drugs. 2020 Jan;31(1):67-72. doi: 10.1097/CAD.0000000000000850.


Online comprehensive hydrophilic interaction chromatography × reversed phase liquid chromatography coupled to mass spectrometry for in depth peptidomic profile of microalgae gastro-intestinal digests.

Sommella E, Salviati E, Merciai F, Manfra M, Bertamino A, Gasparrini F, Novellino E, Campiglia P.

J Pharm Biomed Anal. 2019 Oct 25;175:112783. doi: 10.1016/j.jpba.2019.112783. Epub 2019 Jul 19.


Yield parameters and antioxidant compounds of tomato fruit: the role of plant defence inducers with or without Cucumber mosaic virus infection.

Rendina N, Nuzzaci M, Sofo A, Campiglia P, Scopa A, Sommella E, Pepe G, De Nisco M, Basilicata MG, Manfra M.

J Sci Food Agric. 2019 Sep;99(12):5541-5549. doi: 10.1002/jsfa.9818. Epub 2019 Jul 2.


Polyphenolic Extract from Tarocco (Citrus sinensis L. Osbeck) Clone "Lempso" Exerts Anti-Inflammatory and Antioxidant Effects via NF-kB and Nrf-2 Activation in Murine Macrophages.

Pepe G, Sommella E, Cianciarulo D, Ostacolo C, Manfra M, Di Sarno V, Musella S, Russo M, Messore A, Parrino B, Bertamino A, Autore G, Marzocco S, Campiglia P.

Nutrients. 2018 Dec 11;10(12). pii: E1961. doi: 10.3390/nu10121961.


Peptidome profiles and bioactivity elucidation of buffalo-milk dairy products after gastrointestinal digestion.

Basilicata MG, Pepe G, Sommella E, Ostacolo C, Manfra M, Sosto G, Pagano G, Novellino E, Campiglia P.

Food Res Int. 2018 Mar;105:1003-1010. doi: 10.1016/j.foodres.2017.12.038. Epub 2017 Dec 14.


Chemical profiling of bioactive constituents in hop cones and pellets extracts by online comprehensive two-dimensional liquid chromatography with tandem mass spectrometry and direct infusion Fourier transform ion cyclotron resonance mass spectrometry.

Sommella E, Pagano F, Salviati E, Chieppa M, Bertamino A, Manfra M, Sala M, Novellino E, Campiglia P.

J Sep Sci. 2018 Apr;41(7):1548-1557. doi: 10.1002/jssc.201701242. Epub 2018 Jan 25.


Flavonoid Composition of Tarocco (Citrus sinensis L. Osbeck) Clone "Lempso" and Fast Antioxidant Activity Screening by DPPH-UHPLC-PDA-IT-TOF.

Sommella E, Pagano F, Pepe G, Ostacolo C, Manfra M, Chieppa M, Di Sanzo R, Carabetta S, Campiglia P, Russo M.

Phytochem Anal. 2017 Nov;28(6):521-528. doi: 10.1002/pca.2701. Epub 2017 Jul 7.


Bioavailable Citrus sinensis Extract: Polyphenolic Composition and Biological Activity.

Pepe G, Pagano F, Adesso S, Sommella E, Ostacolo C, Manfra M, Chieppa M, Sala M, Russo M, Marzocco S, Campiglia P.

Molecules. 2017 Apr 15;22(4). pii: E623. doi: 10.3390/molecules22040623.


Identification of novel microsomal prostaglandin E2 synthase-1 (mPGES-1) lead inhibitors from Fragment Virtual Screening.

Lauro G, Manfra M, Pedatella S, Fischer K, Cantone V, Terracciano S, Bertamino A, Ostacolo C, Gomez-Monterrey I, De Nisco M, Riccio R, Novellino E, Werz O, Campiglia P, Bifulco G.

Eur J Med Chem. 2017 Jan 5;125:278-287. doi: 10.1016/j.ejmech.2016.09.042. Epub 2016 Sep 14.


Development and Identification of a Novel Anti-HIV-1 Peptide Derived by Modification of the N-Terminal Domain of HIV-1 Integrase.

Sala M, Spensiero A, Esposito F, Scala MC, Vernieri E, Bertamino A, Manfra M, Carotenuto A, Grieco P, Novellino E, Cadeddu M, Tramontano E, Schols D, Campiglia P, Gomez-Monterrey IM.

Front Microbiol. 2016 Jun 10;7:845. doi: 10.3389/fmicb.2016.00845. eCollection 2016.


Anti-inflammatory and antioxidant activity of polyphenolic extracts from Lactuca sativa (var. Maravilla de Verano) under different farming methods.

Adesso S, Pepe G, Sommella E, Manfra M, Scopa A, Sofo A, Tenore GC, Russo M, Di Gaudio F, Autore G, Campiglia P, Marzocco S.

J Sci Food Agric. 2016 Sep;96(12):4194-206. doi: 10.1002/jsfa.7622. Epub 2016 Mar 1.


Detailed polyphenolic profiling of Annurca apple (M. pumila Miller cv Annurca) by a combination of RP-UHPLC and HILIC, both hyphenated to IT-TOF mass spectrometry.

Sommella E, Pepe G, Pagano F, Ostacolo C, Tenore GC, Russo MT, Novellino E, Manfra M, Campiglia P.

Food Res Int. 2015 Oct;76(Pt 3):466-477. doi: 10.1016/j.foodres.2015.05.044. Epub 2015 May 29.


Dihydrithieno[2,3-b]naphto-4,9-dione analogues as anticancer agents: Synthesis and in cell pharmacological studies.

Bertamino A, Musella S, Di Sarno V, Ostacolo C, Manfra M, Vanacore D, Stiuso P, Novellino E, Campiglia P, Gomez-Monterrey IM.

Eur J Med Chem. 2015 Sep 18;102:106-14. doi: 10.1016/j.ejmech.2015.07.044. Epub 2015 Jul 26.


Evaluation of two sub-2 μm stationary phases, core-shell and totally porous monodisperse, in the second dimension of on-line comprehensive two dimensional liquid chromatography, a case study: separation of milk peptides after expiration date.

Sommella E, Pepe G, Ventre G, Pagano F, Manfra M, Pierri G, Ismail O, Ciogli A, Campiglia P.

J Chromatogr A. 2015 Jan 2;1375:54-61. doi: 10.1016/j.chroma.2014.11.072. Epub 2014 Dec 4.


Evaluation of anti-inflammatory activity and fast UHPLC-DAD-IT-TOF profiling of polyphenolic compounds extracted from green lettuce (Lactuca sativa L.; var. Maravilla de Verano).

Pepe G, Sommella E, Manfra M, De Nisco M, Tenore GC, Scopa A, Sofo A, Marzocco S, Adesso S, Novellino T, Campiglia P.

Food Chem. 2015 Jan 15;167:153-61. doi: 10.1016/j.foodchem.2014.06.105. Epub 2014 Jul 4.


Ultra high performance liquid chromatography with ion-trap TOF-MS for the fast characterization of flavonoids in Citrus bergamia juice.

Sommella E, Pepe G, Pagano F, Tenore GC, Dugo P, Manfra M, Campiglia P.

J Sep Sci. 2013 Oct;36(20):3351-5. doi: 10.1002/jssc.201300591. Epub 2013 Aug 28.


Polyphenolic pattern and in vitro cardioprotective properties of typical red wines from vineyards cultivated in Scafati (Salerno, Italy).

Tenore GC, Manfra M, Stiuso P, Coppola L, Russo M, Ritieni A, Campiglia P.

Food Chem. 2013 Oct 15;140(4):803-9. doi: 10.1016/j.foodchem.2012.10.023. Epub 2012 Nov 6.


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