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J Biomech Eng. 2016 Dec 1;138(12). doi: 10.1115/1.4034507.

A Macroscopic Model for Simulating the Mucociliary Clearance in a Bronchial Bifurcation: The Role of Surface Tension.

Author information

1
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109;Laboratoire de Physique de la Matière Condensée, Ecole Polytechnique, CNRS, Université Paris-Saclay, Palaiseau Cedex 91128, France e-mail: mihalis@umich.edu.
2
Professor Inserm, U955 (Equipe13) and CNRS ERL 7240, Cell and Respiratory Biomechanics, Université Paris Est, Créteil 94010, France e-mail: daniel.isabey@inserm.fr.
3
Inserm, U955 (Equipe13) and CNRS ERL 7240, Cell and Respiratory Biomechanics, Université Paris Est, Créteil 94010, France e-mail: bruno.louis@inserm.fr.
4
Professor Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109 e-mail: grotberg@umich.edu.
5
Professor Laboratoire de Physique de la Matière Condensée, Ecole Polytechnique, CNRS, Université Paris-Saclay, Palaiseau Cedex 91128, France; Inserm, U955 (Equipe13) and CNRS ERL 7240, Cell and Respiratory Biomechanics, Université Paris Est, Créteil 94010, France e-ail: marcel.filoche@polytechnique.edu.

Abstract

The mucociliary clearance in the bronchial tree is the main mechanism by which the lungs clear themselves of deposited particulate matter. In this work, a macroscopic model of the clearance mechanism is proposed. Lubrication theory is applied for thin films with both surface tension effects and a moving wall boundary. The flow field is computed by the use of a finite-volume scheme on an unstructured grid that replicates a bronchial bifurcation. The carina in bronchial bifurcations is of special interest because it is a location of increased deposition of inhaled particles. In this study, the mucus flow is computed for different values of the surface tension. It is found that a minimal surface tension is necessary for efficiently removing the mucus while maintaining the mucus film thickness at physiological levels.

PMID:
27551810
DOI:
10.1115/1.4034507
[Indexed for MEDLINE]

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