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Items: 1 to 20 of 57


Novel Approaches to Persistent Pain Therapy.

Sisignano M, Parnham MJ, Geisslinger G.

Trends Pharmacol Sci. 2019 Jun;40(6):367-377. doi: 10.1016/ Epub 2019 May 8. Review.


Tolerizing CTL by Sustained Hepatic PD-L1 Expression Provides a New Therapy Approach in Mouse Sepsis.

von Knethen A, Schäfer A, Kuchler L, Knape T, Christen U, Hintermann E, Fißlthaler B, Schröder K, Brandes RP, Genz B, Abshagen K, Pützer BM, Sha LK, Weigert A, Syed SN, Schulz M, Shah AM, Ernst A, Putyrski M, Finkelmeier F, Pesic M, Greten F, Hogardt M, Kempf VAJ, Gunne S, Parnham MJ, Brüne B.

Theranostics. 2019 Mar 16;9(7):2003-2016. doi: 10.7150/thno.28057. eCollection 2019.


IL-38 Ameliorates Skin Inflammation and Limits IL-17 Production from γδ T Cells.

Han Y, Mora J, Huard A, da Silva P, Wiechmann S, Putyrski M, Schuster C, Elwakeel E, Lang G, Scholz A, Scholz T, Schmid T, de Bruin N, Billuart P, Sala C, Burkhardt H, Parnham MJ, Ernst A, Brüne B, Weigert A.

Cell Rep. 2019 Apr 16;27(3):835-846.e5. doi: 10.1016/j.celrep.2019.03.082.


Potential biomarkers for persistent and neuropathic pain therapy.

Sisignano M, Lötsch J, Parnham MJ, Geisslinger G.

Pharmacol Ther. 2019 Jul;199:16-29. doi: 10.1016/j.pharmthera.2019.02.004. Epub 2019 Feb 10. Review.


Ceramides as Novel Disease Biomarkers.

Kurz J, Parnham MJ, Geisslinger G, Schiffmann S.

Trends Mol Med. 2019 Jan;25(1):20-32. doi: 10.1016/j.molmed.2018.10.009. Epub 2018 Nov 23. Review.


Stimulating brain recovery after stroke using theranostic albumin nanocarriers loaded with nerve growth factor in combination therapy.

Feczkó T, Piiper A, Ansar S, Blixt FW, Ashtikar M, Schiffmann S, Ulshöfer T, Parnham MJ, Harel Y, Israel LL, Lellouche JP, Wacker MG.

J Control Release. 2019 Jan 10;293:63-72. doi: 10.1016/j.jconrel.2018.11.017. Epub 2018 Nov 17.


Predictive PBPK modeling as a tool in the formulation of the drug candidate TMP-001.

Nothnagel L, Jung F, Rossmanith T, Thurn M, Ashtikar M, Geisslinger G, Parnham MJ, Wacker MG.

Eur J Pharm Biopharm. 2019 Jan;134:144-152. doi: 10.1016/j.ejpb.2018.11.012. Epub 2018 Nov 16.


The relevance of ceramides and their synthesizing enzymes for multiple sclerosis.

Kurz J, Brunkhorst R, Foerch C, Blum L, Henke M, Gabriel L, Ulshöfer T, Ferreirós N, Parnham MJ, Geisslinger G, Schiffmann S.

Clin Sci (Lond). 2018 Aug 17;132(17):1963-1976. doi: 10.1042/CS20180506. Print 2018 Sep 14.


Dietary phytol reduces clinical symptoms in experimental autoimmune encephalomyelitis (EAE) at least partially by modulating NOX2 expression.

Blum L, Tafferner N, Spring I, Kurz J, deBruin N, Geisslinger G, Parnham MJ, Schiffmann S.

J Mol Med (Berl). 2018 Oct;96(10):1131-1144. doi: 10.1007/s00109-018-1689-7. Epub 2018 Aug 27.


An in vitro test system for compounds that modulate human inflammatory macrophage polarization.

Shiratori H, Feinweber C, Luckhardt S, Wallner N, Geisslinger G, Weigert A, Parnham MJ.

Eur J Pharmacol. 2018 Aug 15;833:328-338. doi: 10.1016/j.ejphar.2018.06.017. Epub 2018 Jun 18.


Nrf2, the Master Regulator of Anti-Oxidative Responses.

Vomund S, Schäfer A, Parnham MJ, Brüne B, von Knethen A.

Int J Mol Sci. 2017 Dec 20;18(12). pii: E2772. doi: 10.3390/ijms18122772. Review.


Apoptotic Diminution of Immature Single and Double Positive Thymocyte Subpopulations Contributes to Thymus Involution During Murine Polymicrobial Sepsis.

Netzer C, Knape T, Kuchler L, Weigert A, Zacharowski K, Pfeilschifter W, Sempowski G, Parnham MJ, Brüne B, von Knethen A.

Shock. 2017 Aug;48(2):215-226. doi: 10.1097/SHK.0000000000000842.


Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase: A Possible Key to Future Antileukotriene Therapy.

Roos J, Peters M, Maucher IV, Kühn B, Fettel J, Hellmuth N, Brat C, Sommer B, Urbschat A, Piesche M, Vogel A, Proschak E, Blöcher R, Buscató E, Häfner AK, Matrone C, Werz O, Heidler J, Wittig I, Angioni C, Geisslinger G, Parnham MJ, Zacharowski K, Steinhilber D, Maier TJ.

Antioxid Redox Signal. 2018 May 10;28(14):1265-1285. doi: 10.1089/ars.2017.7155. Epub 2017 Sep 8.


THP-1 and human peripheral blood mononuclear cell-derived macrophages differ in their capacity to polarize in vitro.

Shiratori H, Feinweber C, Luckhardt S, Linke B, Resch E, Geisslinger G, Weigert A, Parnham MJ.

Mol Immunol. 2017 Aug;88:58-68. doi: 10.1016/j.molimm.2017.05.027. Epub 2017 Jun 7.


Drugging the pain epigenome.

Niederberger E, Resch E, Parnham MJ, Geisslinger G.

Nat Rev Neurol. 2017 Jul;13(7):434-447. doi: 10.1038/nrneurol.2017.68. Epub 2017 May 26. Review.


R-Flurbiprofen Traps Prostaglandins within Cells by Inhibition of Multidrug Resistance-Associated Protein-4.

Wobst I, Ebert L, Birod K, Wegner MS, Hoffmann M, Thomas D, Angioni C, Parnham MJ, Steinhilber D, Tegeder I, Geisslinger G, Grösch S.

Int J Mol Sci. 2016 Dec 30;18(1). pii: E68. doi: 10.3390/ijms18010068.


Michael acceptor containing drugs are a novel class of 5-lipoxygenase inhibitor targeting the surface cysteines C416 and C418.

Maucher IV, Rühl M, Kretschmer SB, Hofmann B, Kühn B, Fettel J, Vogel A, Flügel KT, Manolikakes G, Hellmuth N, Häfner AK, Golghalyani V, Ball AK, Piesche M, Matrone C, Geisslinger G, Parnham MJ, Karas M, Steinhilber D, Roos J, Maier TJ.

Biochem Pharmacol. 2017 Feb 1;125:55-74. doi: 10.1016/j.bcp.2016.11.004. Epub 2016 Nov 4.


Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain.

Sisignano M, Angioni C, Park CK, Meyer Dos Santos S, Jordan H, Kuzikov M, Liu D, Zinn S, Hohman SW, Schreiber Y, Zimmer B, Schmidt M, Lu R, Suo J, Zhang DD, Schäfer SM, Hofmann M, Yekkirala AS, de Bruin N, Parnham MJ, Woolf CJ, Ji RR, Scholich K, Geisslinger G.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12544-12549. Epub 2016 Oct 17.


High-Throughput Analysis of Global DNA Methylation Using Methyl-Sensitive Digestion.

Shiratori H, Feinweber C, Knothe C, Lötsch J, Thomas D, Geisslinger G, Parnham MJ, Resch E.

PLoS One. 2016 Oct 17;11(10):e0163184. doi: 10.1371/journal.pone.0163184. eCollection 2016.


Progress does not just come in giant leaps: adapting techniques for the study of inflammation to novel applications.

Parnham MJ.

Inflamm Res. 2017 Jan;66(1):1-12. doi: 10.1007/s00011-016-0988-0. Epub 2016 Sep 28.


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