Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 20 of 132

1.

Synthesis, Structural Characterization, and Antiangiogenic Activity of Polyfluorinated Benzamides.

Steinebach C, Ambrożak A, Dosa S, Beedie SL, Strope JD, Schnakenburg G, Figg WD, Gütschow M.

ChemMedChem. 2018 Aug 22. doi: 10.1002/cmdc.201800263. [Epub ahead of print]

PMID:
30134015
2.

Homo-PROTACs for the Chemical Knockdown of Cereblon.

Steinebach C, Lindner S, Udeshi ND, Mani DC, Kehm H, Köpff S, Carr SA, Gütschow M, Krönke J.

ACS Chem Biol. 2018 Sep 5. doi: 10.1021/acschembio.8b00693. [Epub ahead of print]

PMID:
30118587
3.

Crystal structure of highly glycosylated human leukocyte elastase in complex with an S2' site binding inhibitor.

Hochscherf J, Pietsch M, Tieu W, Kuan K, Abell AD, Gütschow M, Niefind K.

Acta Crystallogr F Struct Biol Commun. 2018 Aug 1;74(Pt 8):480-489. doi: 10.1107/S2053230X1800537X. Epub 2018 Jul 26.

PMID:
30084397
4.

ω-Phthalimidoalkyl Aryl Ureas as Potent and Selective Inhibitors of Cholesterol Esterase.

Dato FM, Sheikh M, Uhl RZ, Schüller AW, Steinkrüger M, Koch P, Neudörfl JM, Gütschow M, Goldfuss B, Pietsch M.

ChemMedChem. 2018 Sep 6;13(17):1833-1847. doi: 10.1002/cmdc.201800388. Epub 2018 Aug 13.

PMID:
30004170
5.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-3.

Mangoni AA, Tuccinardi T, Collina S, Vanden Eynde JJ, Muñoz-Torrero D, Karaman R, Siciliano C, de Sousa ME, Prokai-Tatrai K, Rautio J, Guillou C, Gütschow M, Galdiero S, Liu H, Agrofoglio LA, Sabatier JM, Hulme C, Kokotos G, You Q, Gomes PAC.

Molecules. 2018 Jun 30;23(7). pii: E1596. doi: 10.3390/molecules23071596. No abstract available.

6.

A Short Peptide Inhibitor as an Activity-Based Probe for Matriptase-2.

Mangold M, Gütschow M, Stirnberg M.

Pharmaceuticals (Basel). 2018 May 21;11(2). pii: E49. doi: 10.3390/ph11020049.

7.

Synthesis and kinetic evaluation of ethyl acrylate and vinyl sulfone derived inhibitors for human cysteine cathepsins.

Breuer C, Lemke C, Schmitz J, Bartz U, Gütschow M.

Bioorg Med Chem Lett. 2018 Jun 15;28(11):2008-2012. doi: 10.1016/j.bmcl.2018.05.005. Epub 2018 May 4.

PMID:
29748052
8.

A BODIPY-Tagged Phosphono Peptide as Activity-Based Probe for Human Leukocyte Elastase.

Schulz-Fincke AC, Blaut M, Braune A, Gütschow M.

ACS Med Chem Lett. 2018 Mar 4;9(4):345-350. doi: 10.1021/acsmedchemlett.7b00533. eCollection 2018 Apr 12.

PMID:
29670698
9.

X-ray Structures of Target-Ligand Complexes Containing Compounds with Assay Interference Potential.

Gilberg E, Gütschow M, Bajorath J.

J Med Chem. 2018 Feb 8;61(3):1276-1284. doi: 10.1021/acs.jmedchem.7b01780. Epub 2018 Jan 24.

PMID:
29328660
10.

Bioanalytical verification of V-type nerve agent exposure: simultaneous detection of phosphonylated tyrosines and cysteine-containing disulfide-adducts derived from human albumin.

Kranawetvogl A, Küppers J, Siegert M, Gütschow M, Worek F, Thiermann H, Elsinghorst PW, John H.

Anal Bioanal Chem. 2018 Feb;410(5):1463-1474. doi: 10.1007/s00216-017-0787-7. Epub 2018 Jan 10.

PMID:
29322229
11.

Design of an Activity-Based Probe for Human Neutrophil Elastase: Implementation of the Lossen Rearrangement To Induce Förster Resonance Energy Transfers.

Schulz-Fincke AC, Tikhomirov AS, Braune A, Girbl T, Gilberg E, Bajorath J, Blaut M, Nourshargh S, Gütschow M.

Biochemistry. 2018 Feb 6;57(5):742-752. doi: 10.1021/acs.biochem.7b00906. Epub 2018 Jan 16.

PMID:
29286643
12.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-2.

Muñoz-Torrero D, Mangoni AA, Liu H, Hulme C, Rautio J, Karaman R, de Sousa ME, Prokai-Tatrai K, Sabatier JM, Siciliano C, Luque FJ, Kokotos G, Ragno R, Collina S, Guillou C, Gütschow M, Agrofoglio LA.

Molecules. 2017 Dec 28;23(1). pii: E65. doi: 10.3390/molecules23010065.

13.

Differential ability of proinflammatory and anti-inflammatory macrophages to perform macropinocytosis.

Redka DS, Gütschow M, Grinstein S, Canton J.

Mol Biol Cell. 2018 Jan 1;29(1):53-65. doi: 10.1091/mbc.E17-06-0419. Epub 2017 Nov 1.

14.

CPS49-induced neurotoxicity does not cause limb patterning anomalies in developing chicken embryos.

Mahony C, McMenemy S, Rafipay AJ, Beedie SL, Fraga LR, Gütschow M, Figg WD, Erskine L, Vargesson N.

J Anat. 2018 Apr;232(4):568-574. doi: 10.1111/joa.12712. Epub 2017 Oct 10.

PMID:
29023763
15.

Design and chemical syntheses of potent matriptase-2 inhibitors based on trypsin inhibitor SFTI-1 isolated from sunflower seeds.

Gitlin-Domagalska A, Dębowski D, Łęgowska A, Stirnberg M, Okońska J, Gütschow M, Rolka K.

Biopolymers. 2017 Nov;108(6). doi: 10.1002/bip.23031.

PMID:
28555756
16.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes.

Muñoz-Torrero D, Mangoni AA, Guillou C, Collina S, Vanden Eynde JJ, Rautio J, Keserű GM, Hulme C, Chibale K, Luque FJ, Karaman R, Gütschow M, Liu H, Ragno R.

Molecules. 2017 May 5;22(5). pii: E743. doi: 10.3390/molecules22050743.

17.

Privileged Structural Motif Detection and Analysis Using Generative Topographic Maps.

Kayastha S, Horvath D, Gilberg E, Gütschow M, Bajorath J, Varnek A.

J Chem Inf Model. 2017 May 22;57(5):1218-1232. doi: 10.1021/acs.jcim.7b00128. Epub 2017 Apr 21.

PMID:
28409625
18.

A Fluorescent-Labeled Phosphono Bisbenzguanidine As an Activity-Based Probe for Matriptase.

Häußler D, Schulz-Fincke AC, Beckmann AM, Keils A, Gilberg E, Mangold M, Bajorath J, Stirnberg M, Steinmetzer T, Gütschow M.

Chemistry. 2017 Apr 19;23(22):5205-5209. doi: 10.1002/chem.201700319. Epub 2017 Mar 28.

PMID:
28370501
19.

Crosstalk between angiotensin and the nonamyloidogenic pathway of Alzheimer's amyloid precursor protein.

Kanarek AM, Wagner A, Küppers J, Gütschow M, Postina R, Kojro E.

FEBS J. 2017 Mar;284(5):742-753. doi: 10.1111/febs.14015. Epub 2017 Feb 10.

20.

Biosynthetic Studies on Acetosellin and Structure Elucidation of a New Acetosellin Derivative.

Hufendiek P, Stölben SSM, Kehraus S, Merten N, Harms H, Crüsemann M, Arslan I, Gütschow M, Schneider T, König GM.

Planta Med. 2017 Aug;83(12-13):1044-1052. doi: 10.1055/s-0042-124493. Epub 2017 Jan 12.

PMID:
28081580

Supplemental Content

Loading ...
Support Center