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Items: 1 to 20 of 152

1.

Glutamine-induced signaling pathways via amino acid receptors in enteroendocrine L cell line.

Nakamura T, Harada K, Kamiya T, Takizawa M, Küppers J, Nakajima K, Gütschow M, Kitaguchi T, Ohta K, Kato T, Tsuboi T.

J Mol Endocrinol. 2020 Jan 1. pii: JME-19-0260.R1. doi: 10.1530/JME-19-0260. [Epub ahead of print]

PMID:
31940281
2.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-6.

Vanden Eynde JJ, Mangoni AA, Rautio J, Leprince J, Azuma YT, García-Sosa AT, Hulme C, Jampilek J, Karaman R, Li W, Gomes PAC, Hadjipavlou-Litina D, Capasso R, Geronikaki A, Cerchia L, Sabatier JM, Ragno R, Tuccinardi T, Trabocchi A, Winum JY, Luque FJ, Prokai-Tatrai K, Spetea M, Gütschow M, Kosalec I, Guillou C, Vasconcelos MH, Kokotos G, Rastelli G, de Sousa ME, Manera C, Gemma S, Mangani S, Siciliano C, Galdiero S, Liu H, Scott PJH, de Los Ríos C, Agrofoglio LA, Collina S, Guedes RC, Muñoz-Torrero D.

Molecules. 2019 Dec 28;25(1). pii: E119. doi: 10.3390/molecules25010119.

3.

Chromenones as Multineurotargeting Inhibitors of Human Enzymes.

Lemke C, Christmann J, Yin J, Alonso JM, Serrano E, Chioua M, Ismaili L, Martínez-Grau MA, Beadle CD, Vetman T, Dato FM, Bartz U, Elsinghorst PW, Pietsch M, Müller CE, Iriepa I, Wille T, Marco-Contelles J, Gütschow M.

ACS Omega. 2019 Dec 11;4(26):22161-22168. doi: 10.1021/acsomega.9b03409. eCollection 2019 Dec 24.

4.

Cell-permeable high-affinity tracers for Gq proteins provide structural insights, reveal distinct binding kinetics, and identify small molecule inhibitors.

Kuschak M, Namasivayam V, Rafehi M, Voss JH, Garg J, Schlegel JG, Abdelrahman A, Kehraus S, Reher R, Küppers J, Sylvester K, Hinz S, Matthey M, Wenzel D, Fleischmann BK, Pfeifer A, Inoue A, Gütschow M, König GM, Müller CE.

Br J Pharmacol. 2019 Dec 27. doi: 10.1111/bph.14960. [Epub ahead of print]

PMID:
31881095
5.

ω-Quinazolinonylalkyl aryl ureas as reversible inhibitors of monoacylglycerol lipase.

Dato FM, Neudörfl JM, Gütschow M, Goldfuss B, Pietsch M.

Bioorg Chem. 2020 Jan;94:103352. doi: 10.1016/j.bioorg.2019.103352. Epub 2019 Oct 12.

PMID:
31668797
6.

3-Amidinophenylalanine-derived matriptase inhibitors can modulate hepcidin production in vitro.

Pászti-Gere E, Szombath G, Gütschow M, Steinmetzer T, Székács A.

Naunyn Schmiedebergs Arch Pharmacol. 2019 Oct 28. doi: 10.1007/s00210-019-01743-x. [Epub ahead of print]

PMID:
31659405
7.

Promiscuous Ligands from Experimentally Determined Structures, Binding Conformations, and Protein Family-Dependent Interaction Hotspots.

Gilberg E, Gütschow M, Bajorath J.

ACS Omega. 2019 Jan 22;4(1):1729-1737. doi: 10.1021/acsomega.8b03481. eCollection 2019 Jan 31.

8.

An NADH-Dependent Reductase from Eubacterium ramulus Catalyzes the Stereospecific Heteroring Cleavage of Flavanones and Flavanonols.

Braune A, Gütschow M, Blaut M.

Appl Environ Microbiol. 2019 Sep 17;85(19). pii: e01233-19. doi: 10.1128/AEM.01233-19. Print 2019 Oct 1.

PMID:
31375488
9.

Can Cysteine Protease Cross-Class Inhibitors Achieve Selectivity?

Cianni L, Feldmann CW, Gilberg E, Gütschow M, Juliano L, Leitão A, Bajorath J, Montanari CA.

J Med Chem. 2019 Dec 12;62(23):10497-10525. doi: 10.1021/acs.jmedchem.9b00683. Epub 2019 Aug 15.

PMID:
31361135
10.

A MedChem toolbox for cereblon-directed PROTACs.

Steinebach C, Sosič I, Lindner S, Bricelj A, Kohl F, Ng YLD, Monschke M, Wagner KG, Krönke J, Gütschow M.

Medchemcomm. 2019 May 28;10(6):1037-1041. doi: 10.1039/c9md00185a. eCollection 2019 Jun 1.

PMID:
31304001
11.

Cysteine-type cathepsins promote the effector phase of acute cutaneous delayed-type hypersensitivity reactions.

Schwenck J, Maurer A, Fehrenbacher B, Mehling R, Knopf P, Mucha N, Haupt D, Fuchs K, Griessinger CM, Bukala D, Holstein J, Schaller M, Menendez IG, Ghoreschi K, Quintanilla-Martinez L, Gütschow M, Laufer S, Reinheckel T, Röcken M, Kalbacher H, Pichler BJ, Kneilling M.

Theranostics. 2019 May 31;9(13):3903-3917. doi: 10.7150/thno.31037. eCollection 2019.

12.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5.

Mangoni AA, Eynde JJV, Jampilek J, Hadjipavlou-Litina D, Liu H, Reynisson J, Sousa ME, Gomes PAC, Prokai-Tatrai K, Tuccinardi T, Sabatier JM, Luque FJ, Rautio J, Karaman R, Vasconcelos MH, Gemma S, Galdiero S, Hulme C, Collina S, Gütschow M, Kokotos G, Siciliano C, Capasso R, Agrofoglio LA, Ragno R, Muñoz-Torrero D.

Molecules. 2019 Jun 30;24(13). pii: E2415. doi: 10.3390/molecules24132415.

13.

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs.

Lindner S, Steinebach C, Kehm H, Mangold M, Gütschow M, Krönke J.

J Vis Exp. 2019 May 15;(147). doi: 10.3791/59472.

PMID:
31157769
14.

Synthesis and preliminary radiopharmacological characterisation of an 11 C-labelled azadipeptide nitrile as potential PET tracer for imaging of cysteine cathepsins.

Laube M, Frizler M, Wodtke R, Neuber C, Belter B, Kniess T, Bachmann M, Gütschow M, Pietzsch J, Löser R.

J Labelled Comp Radiopharm. 2019 Jun 30;62(8):448-459. doi: 10.1002/jlcr.3729. Epub 2019 May 15.

PMID:
30912586
15.

PROTAC-mediated crosstalk between E3 ligases.

Steinebach C, Kehm H, Lindner S, Vu LP, Köpff S, López Mármol Á, Weiler C, Wagner KG, Reichenzeller M, Krönke J, Gütschow M.

Chem Commun (Camb). 2019 Feb 5;55(12):1821-1824. doi: 10.1039/c8cc09541h.

PMID:
30672516
16.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes⁻4.

Mangoni AA, Guillou C, Vanden Eynde JJ, Hulme C, Jampilek J, Li W, Prokai-Tatrai K, Rautio J, Collina S, Tuccinardi T, Sousa ME, Sabatier JM, Galdiero S, Karaman R, Kokotos G, Torri G, Luque FJ, Vasconcelos MH, Hadjipavlou-Litina D, Siciliano C, Gütschow M, Ragno R, Gomes PAC, Agrofoglio LA, Muñoz-Torrero D.

Molecules. 2018 Dec 31;24(1). pii: E130. doi: 10.3390/molecules24010130.

17.

Label-Free Whole Cell Biosensing for High-Throughput Discovery of Activators and Inhibitors Targeting G Protein-Activated Inwardly Rectifying Potassium Channels.

Krebs KM, Pfeil EM, Simon K, Grundmann M, Häberlein F, Bautista-Aguilera OM, Gütschow M, Weaver CD, Fleischmann BK, Kostenis E.

ACS Omega. 2018 Nov 30;3(11):14814-14823. doi: 10.1021/acsomega.8b02254. Epub 2018 Nov 5.

18.

Matriptase-2: monitoring and inhibiting its proteolytic activity.

Gitlin-Domagalska A, Mangold M, Dębowski D, Ptaszyńska N, Łęgowska A, Gütschow M, Rolka K.

Future Med Chem. 2018 Dec 6. doi: 10.4155/fmc-2018-0346. [Epub ahead of print]

PMID:
30518272
19.

Cathepsin B: Active site mapping with peptidic substrates and inhibitors.

Schmitz J, Gilberg E, Löser R, Bajorath J, Bartz U, Gütschow M.

Bioorg Med Chem. 2019 Jan 1;27(1):1-15. doi: 10.1016/j.bmc.2018.10.017. Epub 2018 Oct 19. Review.

PMID:
30473362
20.

Synthesis, Structural Characterization, and Antiangiogenic Activity of Polyfluorinated Benzamides.

Steinebach C, Ambrożak A, Dosa S, Beedie SL, Strope JD, Schnakenburg G, Figg WD, Gütschow M.

ChemMedChem. 2018 Oct 8;13(19):2080-2089. doi: 10.1002/cmdc.201800263. Epub 2018 Sep 6.

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