Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 20 of 138

1.

PROTAC-mediated crosstalk between E3 ligases.

Steinebach C, Kehm H, Lindner S, Vu LP, Köpff S, López Mármol Á, Weiler C, Wagner KG, Reichenzeller M, Krönke J, Gütschow M.

Chem Commun (Camb). 2019 Feb 5;55(12):1821-1824. doi: 10.1039/c8cc09541h.

PMID:
30672516
2.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes⁻4.

Mangoni AA, Guillou C, Vanden Eynde JJ, Hulme C, Jampilek J, Li W, Prokai-Tatrai K, Rautio J, Collina S, Tuccinardi T, Sousa ME, Sabatier JM, Galdiero S, Karaman R, Kokotos G, Torri G, Luque FJ, Vasconcelos MH, Hadjipavlou-Litina D, Siciliano C, Gütschow M, Ragno R, Gomes PAC, Agrofoglio LA, Muñoz-Torrero D.

Molecules. 2018 Dec 31;24(1). pii: E130. doi: 10.3390/molecules24010130.

3.

Label-Free Whole Cell Biosensing for High-Throughput Discovery of Activators and Inhibitors Targeting G Protein-Activated Inwardly Rectifying Potassium Channels.

Krebs KM, Pfeil EM, Simon K, Grundmann M, Häberlein F, Bautista-Aguilera OM, Gütschow M, Weaver CD, Fleischmann BK, Kostenis E.

ACS Omega. 2018 Nov 30;3(11):14814-14823. doi: 10.1021/acsomega.8b02254. Epub 2018 Nov 5.

4.

Matriptase-2: monitoring and inhibiting its proteolytic activity.

Gitlin-Domagalska A, Mangold M, Dębowski D, Ptaszyńska N, Łęgowska A, Gütschow M, Rolka K.

Future Med Chem. 2018 Dec 6. doi: 10.4155/fmc-2018-0346. [Epub ahead of print]

PMID:
30518272
5.

Cathepsin B: Active site mapping with peptidic substrates and inhibitors.

Schmitz J, Gilberg E, Löser R, Bajorath J, Bartz U, Gütschow M.

Bioorg Med Chem. 2019 Jan 1;27(1):1-15. doi: 10.1016/j.bmc.2018.10.017. Epub 2018 Oct 19. Review.

PMID:
30473362
6.

Synthesis, Structural Characterization, and Antiangiogenic Activity of Polyfluorinated Benzamides.

Steinebach C, Ambrożak A, Dosa S, Beedie SL, Strope JD, Schnakenburg G, Figg WD, Gütschow M.

ChemMedChem. 2018 Oct 8;13(19):2080-2089. doi: 10.1002/cmdc.201800263. Epub 2018 Sep 6.

PMID:
30134015
7.

Homo-PROTACs for the Chemical Knockdown of Cereblon.

Steinebach C, Lindner S, Udeshi ND, Mani DC, Kehm H, Köpff S, Carr SA, Gütschow M, Krönke J.

ACS Chem Biol. 2018 Sep 21;13(9):2771-2782. doi: 10.1021/acschembio.8b00693. Epub 2018 Sep 5.

PMID:
30118587
8.

Crystal structure of highly glycosylated human leukocyte elastase in complex with an S2' site binding inhibitor.

Hochscherf J, Pietsch M, Tieu W, Kuan K, Abell AD, Gütschow M, Niefind K.

Acta Crystallogr F Struct Biol Commun. 2018 Aug 1;74(Pt 8):480-489. doi: 10.1107/S2053230X1800537X. Epub 2018 Jul 26.

PMID:
30084397
9.

ω-Phthalimidoalkyl Aryl Ureas as Potent and Selective Inhibitors of Cholesterol Esterase.

Dato FM, Sheikh M, Uhl RZ, Schüller AW, Steinkrüger M, Koch P, Neudörfl JM, Gütschow M, Goldfuss B, Pietsch M.

ChemMedChem. 2018 Sep 6;13(17):1833-1847. doi: 10.1002/cmdc.201800388. Epub 2018 Aug 13.

PMID:
30004170
10.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-3.

Mangoni AA, Tuccinardi T, Collina S, Vanden Eynde JJ, Muñoz-Torrero D, Karaman R, Siciliano C, de Sousa ME, Prokai-Tatrai K, Rautio J, Guillou C, Gütschow M, Galdiero S, Liu H, Agrofoglio LA, Sabatier JM, Hulme C, Kokotos G, You Q, Gomes PAC.

Molecules. 2018 Jun 30;23(7). pii: E1596. doi: 10.3390/molecules23071596. No abstract available.

11.

A Short Peptide Inhibitor as an Activity-Based Probe for Matriptase-2.

Mangold M, Gütschow M, Stirnberg M.

Pharmaceuticals (Basel). 2018 May 21;11(2). pii: E49. doi: 10.3390/ph11020049.

12.

Synthesis and kinetic evaluation of ethyl acrylate and vinyl sulfone derived inhibitors for human cysteine cathepsins.

Breuer C, Lemke C, Schmitz J, Bartz U, Gütschow M.

Bioorg Med Chem Lett. 2018 Jun 15;28(11):2008-2012. doi: 10.1016/j.bmcl.2018.05.005. Epub 2018 May 4.

PMID:
29748052
13.

A BODIPY-Tagged Phosphono Peptide as Activity-Based Probe for Human Leukocyte Elastase.

Schulz-Fincke AC, Blaut M, Braune A, Gütschow M.

ACS Med Chem Lett. 2018 Mar 4;9(4):345-350. doi: 10.1021/acsmedchemlett.7b00533. eCollection 2018 Apr 12.

PMID:
29670698
14.

X-ray Structures of Target-Ligand Complexes Containing Compounds with Assay Interference Potential.

Gilberg E, Gütschow M, Bajorath J.

J Med Chem. 2018 Feb 8;61(3):1276-1284. doi: 10.1021/acs.jmedchem.7b01780. Epub 2018 Jan 24.

PMID:
29328660
15.

Bioanalytical verification of V-type nerve agent exposure: simultaneous detection of phosphonylated tyrosines and cysteine-containing disulfide-adducts derived from human albumin.

Kranawetvogl A, Küppers J, Siegert M, Gütschow M, Worek F, Thiermann H, Elsinghorst PW, John H.

Anal Bioanal Chem. 2018 Feb;410(5):1463-1474. doi: 10.1007/s00216-017-0787-7. Epub 2018 Jan 10.

PMID:
29322229
16.

Design of an Activity-Based Probe for Human Neutrophil Elastase: Implementation of the Lossen Rearrangement To Induce Förster Resonance Energy Transfers.

Schulz-Fincke AC, Tikhomirov AS, Braune A, Girbl T, Gilberg E, Bajorath J, Blaut M, Nourshargh S, Gütschow M.

Biochemistry. 2018 Feb 6;57(5):742-752. doi: 10.1021/acs.biochem.7b00906. Epub 2018 Jan 16.

PMID:
29286643
17.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-2.

Muñoz-Torrero D, Mangoni AA, Liu H, Hulme C, Rautio J, Karaman R, de Sousa ME, Prokai-Tatrai K, Sabatier JM, Siciliano C, Luque FJ, Kokotos G, Ragno R, Collina S, Guillou C, Gütschow M, Agrofoglio LA.

Molecules. 2017 Dec 28;23(1). pii: E65. doi: 10.3390/molecules23010065.

18.

Differential ability of proinflammatory and anti-inflammatory macrophages to perform macropinocytosis.

Redka DS, Gütschow M, Grinstein S, Canton J.

Mol Biol Cell. 2018 Jan 1;29(1):53-65. doi: 10.1091/mbc.E17-06-0419. Epub 2017 Nov 1.

19.

CPS49-induced neurotoxicity does not cause limb patterning anomalies in developing chicken embryos.

Mahony C, McMenemy S, Rafipay AJ, Beedie SL, Fraga LR, Gütschow M, Figg WD, Erskine L, Vargesson N.

J Anat. 2018 Apr;232(4):568-574. doi: 10.1111/joa.12712. Epub 2017 Oct 10.

PMID:
29023763
20.

Design and chemical syntheses of potent matriptase-2 inhibitors based on trypsin inhibitor SFTI-1 isolated from sunflower seeds.

Gitlin-Domagalska A, Dębowski D, Łęgowska A, Stirnberg M, Okońska J, Gütschow M, Rolka K.

Biopolymers. 2017 Nov;108(6). doi: 10.1002/bip.23031.

PMID:
28555756

Supplemental Content

Loading ...
Support Center