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Items: 1 to 20 of 127

1.

Big Lessons from Tiny Flies: Drosophila melanogaster as a Model to Explore Dysfunction of Dopaminergic and Serotonergic Neurotransmitter Systems.

Kasture AS, Hummel T, Sucic S, Freissmuth M.

Int J Mol Sci. 2018 Jun 16;19(6). pii: E1788. doi: 10.3390/ijms19061788. Review.

2.

Identification and characterization of the Fasciola hepatica sodium- and chloride-dependent taurine transporter.

Hamali B, Pichler S, Wischnitzki E, Schicker K, Burger M, Holy M, Jaentsch K, Molin M, Sehr EM, Kudlacek O, Freissmuth M.

PLoS Negl Trop Dis. 2018 Apr 27;12(4):e0006428. doi: 10.1371/journal.pntd.0006428. eCollection 2018 Apr.

3.

A label-free approach to detect ligand binding to cell surface proteins in real time.

Burtscher V, Hotka M, Li Y, Freissmuth M, Sandtner W.

Elife. 2018 Apr 26;7. pii: e34944. doi: 10.7554/eLife.34944.

4.

A kinetic account for amphetamine-induced monoamine release.

Hasenhuetl PS, Bhat S, Mayer FP, Sitte HH, Freissmuth M, Sandtner W.

J Gen Physiol. 2018 Feb 9. pii: jgp.201711915. doi: 10.1085/jgp.201711915. [Epub ahead of print]

5.

Clinoptilolite in Dextran Sulphate Sodium-Induced Murine Colitis: Efficacy and Safety of a Microparticulate Preparation.

Nizet S, Muñoz E, Fiebich BL, Abuja PM, Kashofer K, Zatloukal K, Tangermann S, Kenner L, Tschegg C, Nagl D, Scheichl L, Meisslitzer-Ruppitsch C, Freissmuth M, Berger T.

Inflamm Bowel Dis. 2017 Dec 19;24(1):54-66. doi: 10.1093/ibd/izx042.

PMID:
29272495
6.

Relax, Cool Down and Scaffold: How to Restore Surface Expression of Folding-Deficient Mutant GPCRs and SLC6 Transporters.

Asjad HMM, Nasrollahi-Shirazi S, Sucic S, Freissmuth M, Nanoff C.

Int J Mol Sci. 2017 Nov 14;18(11). pii: E2416. doi: 10.3390/ijms18112416. Review.

7.

SLC6 Transporter Folding Diseases and Pharmacochaperoning.

Freissmuth M, Stockner T, Sucic S.

Handb Exp Pharmacol. 2018;245:249-270. doi: 10.1007/164_2017_71.

PMID:
29086036
8.

Pharmacochaperoning in a Drosophila model system rescues human dopamine transporter variants associated with infantile/juvenile parkinsonism.

Asjad HMM, Kasture A, El-Kasaby A, Sackel M, Hummel T, Freissmuth M, Sucic S.

J Biol Chem. 2017 Nov 24;292(47):19250-19265. doi: 10.1074/jbc.M117.797092. Epub 2017 Sep 29.

9.

An unfolding story: Small molecules remedy misfolded monoamine transporters.

Kasture A, Stockner T, Freissmuth M, Sucic S.

Int J Biochem Cell Biol. 2017 Nov;92:1-5. doi: 10.1016/j.biocel.2017.09.004. Epub 2017 Sep 7. Review.

10.

Conformational state interactions provide clues to the pharmacochaperone potential of serotonin transporter partial substrates.

Bhat S, Hasenhuetl PS, Kasture A, El-Kasaby A, Baumann MH, Blough BE, Sucic S, Sandtner W, Freissmuth M.

J Biol Chem. 2017 Oct 6;292(40):16773-16786. doi: 10.1074/jbc.M117.794081. Epub 2017 Aug 23.

11.

Hyponatremia and V2 vasopressin receptor upregulation: a result of HSP90 inhibition.

Yang Q, Puhm F, Freissmuth M, Nanoff C.

Cancer Chemother Pharmacol. 2017 Oct;80(4):673-684. doi: 10.1007/s00280-017-3390-x. Epub 2017 Aug 4.

12.

Cocaine adulteration.

Kudlacek O, Hofmaier T, Luf A, Mayer FP, Stockner T, Nagy C, Holy M, Freissmuth M, Schmid R, Sitte HH.

J Chem Neuroanat. 2017 Oct;83-84:75-81. doi: 10.1016/j.jchemneu.2017.06.001. Epub 2017 Jun 12. Review.

PMID:
28619473
13.

Folding correction of ABC-transporter ABCB1 by pharmacological chaperones: a mechanistic concept.

Spork M, Sohail MI, Schmid D, Ecker GF, Freissmuth M, Chiba P, Stockner T.

Pharmacol Res Perspect. 2017 May 26;5(3):e00325. doi: 10.1002/prp2.325. eCollection 2017 Jun.

14.

Occupancy of the zinc-binding site by transition metals decreases the substrate affinity of the human dopamine transporter by an allosteric mechanism.

Li Y, Mayer FP, Hasenhuetl PS, Burtscher V, Schicker K, Sitte HH, Freissmuth M, Sandtner W.

J Biol Chem. 2017 Apr 28;292(17):7161. doi: 10.1074/jbc.A116.760140. No abstract available.

15.

When transporters fail to be transported: how to rescue folding-deficient SLC6 transporters.

Sucic S, Kasture A, Mazhar Asjad HM, Kern C, El-Kasaby A, Freissmuth M.

J Neurol Neuromedicine. 2016 Dec 30;1(9):34-40.

16.

The N Terminus Specifies the Switch between Transport Modes of the Human Serotonin Transporter.

Kern C, Erdem FA, El-Kasaby A, Sandtner W, Freissmuth M, Sucic S.

J Biol Chem. 2017 Mar 3;292(9):3603-3613. doi: 10.1074/jbc.M116.771360. Epub 2017 Jan 19.

17.

Occupancy of the Zinc-binding Site by Transition Metals Decreases the Substrate Affinity of the Human Dopamine Transporter by an Allosteric Mechanism.

Li Y, Mayer FP, Hasenhuetl PS, Burtscher V, Schicker K, Sitte HH, Freissmuth M, Sandtner W.

J Biol Chem. 2017 Mar 10;292(10):4235-4243. doi: 10.1074/jbc.M116.760140. Epub 2017 Jan 17. Erratum in: J Biol Chem. 2017 Apr 28;292(17 ):7161.

18.

Application of a Combined Approach to Identify New Psychoactive Street Drugs and Decipher Their Mechanisms at Monoamine Transporters.

Mayer FP, Luf A, Nagy C, Holy M, Schmid R, Freissmuth M, Sitte HH.

Curr Top Behav Neurosci. 2017;32:333-350. doi: 10.1007/7854_2016_63. Review.

PMID:
28025810
19.

The Environment Shapes the Inner Vestibule of LeuT.

Sohail A, Jayaraman K, Venkatesan S, Gotfryd K, Daerr M, Gether U, Loland CJ, Wanner KT, Freissmuth M, Sitte HH, Sandtner W, Stockner T.

PLoS Comput Biol. 2016 Nov 11;12(11):e1005197. doi: 10.1371/journal.pcbi.1005197. eCollection 2016 Nov.

20.

Several adaptor proteins promote intracellular localisation of the transporter MRP4/ABCC4 in platelets and haematopoietic cells.

Schaletzki Y, Kromrey ML, Bröderdorf S, Hammer E, Grube M, Hagen P, Sucic S, Freissmuth M, Völker U, Greinacher A, Rauch BH, Kroemer HK, Jedlitschky G.

Thromb Haemost. 2017 Jan 5;117(1):105-115. doi: 10.1160/TH16-01-0045. Epub 2016 Oct 20.

PMID:
27761583

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