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Nutrients. 2018 Jan 31;10(2). pii: E160. doi: 10.3390/nu10020160.

A Preliminary Study for Evaluating the Dose-Dependent Effect of d-Allulose for Fat Mass Reduction in Adult Humans: A Randomized, Double-Blind, Placebo-Controlled Trial.

Han Y1,2, Kwon EY3,4, Yu MK5,6, Lee SJ7,8, Kim HJ9, Kim SB10, Kim YH11, Choi MS12,13.

Author information

1
Department of Food Science and Nutrition, Kyungpook National University, 80 Daehakro, Bukgu, Daegu 41566, Korea. youngji.kor.han@hanmail.net.
2
Center for Food and Nutritional Genomics Research, Kyungpook National University, Daegu 41566, Korea. youngji.kor.han@hanmail.net.
3
Department of Food Science and Nutrition, Kyungpook National University, 80 Daehakro, Bukgu, Daegu 41566, Korea. savagegarden01@hanmail.net.
4
Center for Food and Nutritional Genomics Research, Kyungpook National University, Daegu 41566, Korea. savagegarden01@hanmail.net.
5
Department of Food Science and Nutrition, Kyungpook National University, 80 Daehakro, Bukgu, Daegu 41566, Korea. yumeijing@naver.com.
6
Center for Food and Nutritional Genomics Research, Kyungpook National University, Daegu 41566, Korea. yumeijing@naver.com.
7
Department of Food Science and Nutrition, Kyungpook National University, 80 Daehakro, Bukgu, Daegu 41566, Korea. end0901@hanmail.net.
8
Center for Food and Nutritional Genomics Research, Kyungpook National University, Daegu 41566, Korea. end0901@hanmail.net.
9
Food R&D, CJ Cheiljedang Corp., 55, Gwanggyo-ro 42beon-gil, Yeongtong-gu, Suwon-si, Gyeonggi-do 16495, Korea. hyejin.kim@cj.net.
10
Food R&D, CJ Cheiljedang Corp., 55, Gwanggyo-ro 42beon-gil, Yeongtong-gu, Suwon-si, Gyeonggi-do 16495, Korea. seongbo.kim@cj.net.
11
Food R&D, CJ Cheiljedang Corp., 55, Gwanggyo-ro 42beon-gil, Yeongtong-gu, Suwon-si, Gyeonggi-do 16495, Korea. yanghee.kim@cj.net.
12
Department of Food Science and Nutrition, Kyungpook National University, 80 Daehakro, Bukgu, Daegu 41566, Korea. mschoi@knu.ac.kr.
13
Center for Food and Nutritional Genomics Research, Kyungpook National University, Daegu 41566, Korea. mschoi@knu.ac.kr.

Abstract

d-allulose is a rare sugar with zero energy that can be consumed by obese/overweight individuals. Many studies have suggested that zero-calorie d-allulose has beneficial effects on obesity-related metabolism in mouse models, but only a few studies have been performed on human subjects. Therefore, we performed a preliminary study with 121 Korean subjects (aged 20-40 years, body mass index ≥ 23 kg/m²). A randomized controlled trial involving placebo control (sucralose, 0.012 g × 2 times/day), low d-allulose (d-allulose, 4 g × 2 times/day), and high d-allulose (d-allulose, 7 g × 2 times/day) groups was designed. Parameters for body composition, nutrient intake, computed tomography (CT) scan, and plasma lipid profiles were assessed. Body fat percentage and body fat mass were significantly decreased following d-allulose supplementation. The high d-allulose group revealed a significant decrease in not only body mass index (BMI), but also total abdominal and subcutaneous fat areas measured by CT scans compared to the placebo group. There were no significant differences in nutrient intake, plasma lipid profiles, markers of liver and kidney function, and major inflammation markers among groups. These results provide useful information on the dose-dependent effect of d-allulose for overweight/obese adult humans. Based on these results, the efficacy of d-allulose for body fat reduction needs to be validated using dual energy X-ray absorption.

KEYWORDS:

; ">d-allulose; obesity; randomized-controlled trial; sugar substitutes

PMID:
29385054
PMCID:
PMC5852736
DOI:
10.3390/nu10020160
[Indexed for MEDLINE]
Free PMC Article

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