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Items: 16

1.

Large inter-individual variability in pharmacokinetics of dexmedetomidine and its two major N-glucuronides in adult intensive care unit patients.

Yang M, Tse AHW, Lee A, Joynt GM, Zuo Z.

J Pharm Biomed Anal. 2019 Jul 16;175:112777. doi: 10.1016/j.jpba.2019.07.025. [Epub ahead of print]

PMID:
31362246
2.

Reduced Systemic and Brain Exposure with Inhibited Liver Metabolism of Carbamazepine After Its Long-Term Combination Treatment with Piperine for Epilepsy Control in Rats.

Ren T, Xiao M, Yang M, Zhao J, Zhang Y, Hu M, Cheng Y, Xu H, Zhang C, Yan X, Zuo Z.

AAPS J. 2019 Jul 18;21(5):90. doi: 10.1208/s12248-019-0357-3.

PMID:
31321577
3.

Reduced systemic exposure and brain uptake of donepezil in rats with scopolamine-induced cognitive impairment.

Zhao J, Ren T, Yang M, Zhang Y, Wang Q, Zuo Z.

Xenobiotica. 2019 Aug 1:1-12. doi: 10.1080/00498254.2019.1643514. [Epub ahead of print]

PMID:
31298070
4.

Intestinal and hepatic biotransformation of pyrrolizidine alkaloid N-oxides to toxic pyrrolizidine alkaloids.

Yang M, Ma J, Ruan J, Ye Y, Fu PP, Lin G.

Arch Toxicol. 2019 Jun 20. doi: 10.1007/s00204-019-02499-2. [Epub ahead of print]

PMID:
31222523
5.
6.

Impact of the Chinese herbal medicines on dual antiplatelet therapy with clopidogrel and aspirin: Pharmacokinetics and pharmacodynamics outcomes and related mechanisms in rats.

Xiao M, Qian C, Luo X, Yang M, Zhang Y, Wu C, Mok C, Lee P, Zuo Z.

J Ethnopharmacol. 2019 May 10;235:100-110. doi: 10.1016/j.jep.2019.01.040. Epub 2019 Jan 30.

PMID:
30710735
7.

Time-dependent inhibition of carbamazepine metabolism by piperine in anti-epileptic treatment.

Ren T, Yang M, Xiao M, Zhu J, Xie W, Zuo Z.

Life Sci. 2019 Feb 1;218:314-323. doi: 10.1016/j.lfs.2018.12.060. Epub 2019 Jan 3.

PMID:
30611786
8.

Brain-Targeting Delivery of Two Peptidylic Inhibitors for Their Combination Therapy in Transgenic Polyglutamine Disease Mice via Intranasal Administration.

Yang M, Zhang Q, Wang Q, Sørensen KK, Boesen JT, Ma SY, Jensen KJ, Kwan KM, Ngo JCK, Chan HYE, Zuo Z.

Mol Pharm. 2018 Dec 3;15(12):5781-5792. doi: 10.1021/acs.molpharmaceut.8b00938. Epub 2018 Nov 12.

PMID:
30392378
9.

Relationships between the Toxicities of Radix Aconiti Lateralis Preparata (Fuzi) and the Toxicokinetics of Its Main Diester-Diterpenoid Alkaloids.

Yang M, Ji X, Zuo Z.

Toxins (Basel). 2018 Sep 26;10(10). pii: E391. doi: 10.3390/toxins10100391. Review.

10.

Overview of the anti-inflammatory effects, pharmacokinetic properties and clinical efficacies of arctigenin and arctiin from Arctium lappa L.

Gao Q, Yang M, Zuo Z.

Acta Pharmacol Sin. 2018 May;39(5):787-801. doi: 10.1038/aps.2018.32. Epub 2018 Apr 26. Review.

11.

Efficient brain uptake of piperine and its pharmacokinetics characterization after oral administration.

Ren T, Wang Q, Li C, Yang M, Zuo Z.

Xenobiotica. 2018 Dec;48(12):1249-1257. doi: 10.1080/00498254.2017.1405293. Epub 2017 Nov 28.

PMID:
29160763
12.

Impaired liver cytochrome P450 2C11 activity after dual antiplatelet therapy with aspirin and clopidogrel in rats.

Qian C, Luo X, Yang M, Jin J, Zuo Z.

Xenobiotica. 2018 Sep;48(9):911-919. doi: 10.1080/00498254.2017.1380242. Epub 2018 Jan 10.

PMID:
29052493
13.

A brain-targeting lipidated peptide for neutralizing RNA-mediated toxicity in Polyglutamine Diseases.

Zhang Q, Yang M, Sørensen KK, Madsen CS, Boesen JT, An Y, Peng SH, Wei Y, Wang Q, Jensen KJ, Zuo Z, Chan HYE, Ngo JCK.

Sci Rep. 2017 Sep 21;7(1):12077. doi: 10.1038/s41598-017-11695-y.

14.

First evidence of pyrrolizidine alkaloid N-oxide-induced hepatic sinusoidal obstruction syndrome in humans.

Yang M, Ruan J, Gao H, Li N, Ma J, Xue J, Ye Y, Fu PP, Wang J, Lin G.

Arch Toxicol. 2017 Dec;91(12):3913-3925. doi: 10.1007/s00204-017-2013-y. Epub 2017 Jun 15.

PMID:
28620673
15.
16.

Metabolic activation of pyrrolizidine alkaloids: insights into the structural and enzymatic basis.

Ruan J, Yang M, Fu P, Ye Y, Lin G.

Chem Res Toxicol. 2014 Jun 16;27(6):1030-9. doi: 10.1021/tx500071q. Epub 2014 May 22.

PMID:
24836403

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