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Int J Mol Sci. 2018 May 10;19(5). pii: E1425. doi: 10.3390/ijms19051425.

An aPPARent Functional Consequence in Skeletal Muscle Physiology via Peroxisome Proliferator-Activated Receptors.

Phua WWT1,2,3, Wong MXY4, Liao Z5, Tan NS6,7,8,9.

Author information

1
School of Biological Sciences, Nanyang Technological University 60 Nanyang Drive, Singapore 637551, Singapore. wphua003@e.ntu.edu.sg.
2
Lee Kong Chian School of Medicine, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore. wphua003@e.ntu.edu.sg.
3
NTU Institute for Health Technologies, Interdisciplinary Graduate School, Nanyang Technological University, 50 Nanyang Drive, Singapore 637553, Singapore. wphua003@e.ntu.edu.sg.
4
School of Biological Sciences, Nanyang Technological University 60 Nanyang Drive, Singapore 637551, Singapore. mwong018@e.ntu.edu.sg.
5
School of Biological Sciences, Nanyang Technological University 60 Nanyang Drive, Singapore 637551, Singapore. liao0058@e.ntu.edu.sg.
6
School of Biological Sciences, Nanyang Technological University 60 Nanyang Drive, Singapore 637551, Singapore. nstan@ntu.edu.sg.
7
Lee Kong Chian School of Medicine, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore. nstan@ntu.edu.sg.
8
Institute of Molecular and Cell Biology, A*STAR, 61 Biopolis Drive, Proteos, Singapore 138673, Singapore. nstan@ntu.edu.sg.
9
KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore 229899, Singapore. nstan@ntu.edu.sg.

Abstract

Skeletal muscle comprises 30⁻40% of the total body mass and plays a central role in energy homeostasis in the body. The deregulation of energy homeostasis is a common underlying characteristic of metabolic syndrome. Over the past decades, peroxisome proliferator-activated receptors (PPARs) have been shown to play critical regulatory roles in skeletal muscle. The three family members of PPAR have overlapping roles that contribute to the myriad of processes in skeletal muscle. This review aims to provide an overview of the functions of different PPAR members in energy homeostasis as well as during skeletal muscle metabolic disorders, with a particular focus on human and relevant mouse model studies.

KEYWORDS:

aging; insulin resistance; lipid metabolism; muscle regeneration; peroxisome proliferator-activated receptor; physical exercise; skeletal muscle; type 2 diabetes

PMID:
29747466
PMCID:
PMC5983589
DOI:
10.3390/ijms19051425
[Indexed for MEDLINE]
Free PMC Article

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