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In Human and Mouse Spino-Cerebellar Tissue, Ataxin-2 Expansion Affects Ceramide-Sphingomyelin Metabolism.

Sen NE, Arsovic A, Meierhofer D, Brodesser S, Oberschmidt C, Canet-Pons J, Kaya ZE, Halbach MV, Gispert S, Sandhoff K, Auburger G.

Int J Mol Sci. 2019 Nov 21;20(23). pii: E5854. doi: 10.3390/ijms20235854.


Atxn2 Knockout and CAG42-Knock-in Cerebellum Shows Similarly Dysregulated Expression in Calcium Homeostasis Pathway.

Halbach MV, Gispert S, Stehning T, Damrath E, Walter M, Auburger G.

Cerebellum. 2017 Feb;16(1):68-81. doi: 10.1007/s12311-016-0762-4.


Both ubiquitin ligases FBXW8 and PARK2 are sequestrated into insolubility by ATXN2 PolyQ expansions, but only FBXW8 expression is dysregulated.

Halbach MV, Stehning T, Damrath E, Jendrach M, Şen NE, Başak AN, Auburger G.

PLoS One. 2015 Mar 19;10(3):e0121089. doi: 10.1371/journal.pone.0121089. eCollection 2015.

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