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Molecules. 2018 Jun 1;23(6). pii: E1336. doi: 10.3390/molecules23061336.

Sterepinic Acids A⁻C, New Carboxylic Acids Produced by a Marine Alga-Derived Fungus.

Author information

1
Osaka University of Pharmaceutical Sciences, 4-20-1, Nasahara, Takatsuki, Osaka 569-1094, Japan. yamada@gly.oups.ac.jp.
2
Osaka University of Pharmaceutical Sciences, 4-20-1, Nasahara, Takatsuki, Osaka 569-1094, Japan. e12643@gap.oups.ac.jp.
3
Osaka University of Pharmaceutical Sciences, 4-20-1, Nasahara, Takatsuki, Osaka 569-1094, Japan. e10118@gap.oups.ac.jp.
4
Osaka University of Pharmaceutical Sciences, 4-20-1, Nasahara, Takatsuki, Osaka 569-1094, Japan. e11729@gap.oups.ac.jp.
5
Osaka University of Pharmaceutical Sciences, 4-20-1, Nasahara, Takatsuki, Osaka 569-1094, Japan. t.kikuchi@gly.oups.ac.jp.

Abstract

Sterepinic acids A⁻C (13), new carboxylic acids with two primary alcohols, have been isolated from a fungal strain of Stereum sp. OUPS-124D-1 attached to the marine alga Undaria pinnatifida. Dihydro-1,5-secovibralactone (4), a new vibralactone derivative, was isolated from the same fungal metabolites together with known vibralactone A (5), and 1,5-secovibralactone (6). The planar structures of these compounds have been elucidated by spectroscopic analyses using IR, HRFABMS, and NMR spectra. To determine the absolute configuration of the compounds, we used the phenylglycine methyl ester (PGME) method. These compounds exhibited less activity in the cytotoxicity assay against cancer cell lines.

KEYWORDS:

Stereum sp.; Undaria pinnatifida; marine microorganism; phenylglycine methyl ester method; sterepinic acids; vibralactones

PMID:
29865212
DOI:
10.3390/molecules23061336
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