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Nutrients. 2017 Dec 17;9(12). pii: E1367. doi: 10.3390/nu9121367.

The Dual Antioxidant/Prooxidant Effect of Eugenol and Its Action in Cancer Development and Treatment.

Author information

1
Instituto Gonçalo Moniz, Fundação Oswaldo Cruz (IGM-FIOCRUZ/BA), Salvador 40296-710, Bahia, Brazil. danielpbezerra@gmail.com.
2
Departamento de Fisiologia, Universidade Federal de Pernambuco, Recife 50670-901, Pernambuco, Brazil. gcgadelha@yahoo.com.br.
3
Departamento de Ciências Farmacêuticas, Universidade Federal da Paraíba, João Pessoa 58051-970, Paraíba, Brazil. mayaracastrodemorais@gmail.com.
4
Departamento de Ciências Farmacêuticas, Universidade Federal da Paraíba, João Pessoa 58051-970, Paraíba, Brazil. damiao_desousa@yahoo.com.br.

Abstract

The formation of reactive oxygen species (ROS) during metabolism is a normal process usually compensated for by the antioxidant defense system of an organism. However, ROS can cause oxidative damage and have been proposed to be the main cause of age-related clinical complications and diseases such as cancer. In recent decades, the relationship between diet and cancer has been more studied, especially with foods containing antioxidant compounds. Eugenol is a natural compound widely found in many aromatic plant species, spices and foods and is used in cosmetics and pharmaceutical products. Eugenol has a dual effect on oxidative stress, which can action as an antioxidant or prooxidant agent. In addition, it has anti-carcinogenic, cytotoxic and antitumor properties. Considering the importance of eugenol in the area of food and human health, in this review, we discuss the role of eugenol on redox status and its potential use in the treatment and prevention of cancer.

KEYWORDS:

Syzygium aromaticum; antioxidant activity; antitumor activity; clove; essential oils; metabolism; natural products; phenylpropanoid; reactive oxygen species

PMID:
29258206
PMCID:
PMC5748817
DOI:
10.3390/nu9121367
[Indexed for MEDLINE]
Free PMC Article

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