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Items: 1 to 20 of 29

1.

Novel Protein Kinase Inhibitors Related to Tau Pathology Modulate Tau Protein-Self Interaction Using a Luciferase Complementation Assay.

Holzer M, Schade N, Opitz A, Hilbrich I, Stieler J, Vogel T, Neukel V, Oberstadt M, Totzke F, Schächtele C, Sippl W, Hilgeroth A.

Molecules. 2018 Sep 12;23(9). pii: E2335. doi: 10.3390/molecules23092335.

2.

TDP-43 self-interaction is modulated by redox-active compounds Auranofin, Chelerythrine and Riluzole.

Oberstadt M, Stieler J, Simpong DL, Römuß U, Urban N, Schaefer M, Arendt T, Holzer M.

Sci Rep. 2018 Feb 2;8(1):2248. doi: 10.1038/s41598-018-20565-0.

3.

TDP-43 and Cytoskeletal Proteins in ALS.

Oberstadt M, Claßen J, Arendt T, Holzer M.

Mol Neurobiol. 2018 Apr;55(4):3143-3151. doi: 10.1007/s12035-017-0543-1. Epub 2017 May 2. Review.

PMID:
28466273
4.

Tau and tauopathies.

Arendt T, Stieler JT, Holzer M.

Brain Res Bull. 2016 Sep;126(Pt 3):238-292. doi: 10.1016/j.brainresbull.2016.08.018. Epub 2016 Sep 9. Review.

PMID:
27615390
5.

Non-Phosphorylated Tau as a Potential Biomarker of Alzheimer's Disease: Analytical and Diagnostic Characterization.

Lewczuk P, Lelental N, Lachmann I, Holzer M, Flach K, Brandner S, Engelborghs S, Teunissen CE, Zetterberg H, Molinuevo JL, Mroczko B, Blennow K, Popp J, Parnetti L, Chiasserini D, Perret-Liaudet A, Spitzer P, Maler JM, Kornhuber J.

J Alzheimers Dis. 2017;55(1):159-170.

PMID:
27662295
6.

Tau phosphorylation-associated spine regression does not impair hippocampal-dependent memory in hibernating golden hamsters.

Bullmann T, Seeger G, Stieler J, Hanics J, Reimann K, Kretzschmann TP, Hilbrich I, Holzer M, Alpár A, Arendt T.

Hippocampus. 2016 Mar;26(3):301-18. doi: 10.1002/hipo.22522. Epub 2015 Oct 13.

PMID:
26332578
7.

Hook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generation.

Herrmann L, Wiegmann C, Arsalan-Werner A, Hilbrich I, Jäger C, Flach K, Suttkus A, Lachmann I, Arendt T, Holzer M.

PLoS One. 2015 Mar 23;10(3):e0119423. doi: 10.1371/journal.pone.0119423. eCollection 2015.

8.

Brain hypometabolism triggers PHF-like phosphorylation of tau, a major hallmark of Alzheimer's disease pathology.

Arendt T, Stieler J, Holzer M.

J Neural Transm (Vienna). 2015 Apr;122(4):531-9. doi: 10.1007/s00702-014-1342-8. Epub 2014 Dec 6. Review.

PMID:
25480630
9.

Tenascin-R promotes assembly of the extracellular matrix of perineuronal nets via clustering of aggrecan.

Morawski M, Dityatev A, Hartlage-Rübsamen M, Blosa M, Holzer M, Flach K, Pavlica S, Dityateva G, Grosche J, Brückner G, Schachner M.

Philos Trans R Soc Lond B Biol Sci. 2014 Oct 19;369(1654):20140046. doi: 10.1098/rstb.2014.0046.

10.

The Ca2+ sensor protein swiprosin-1/EFhd2 is present in neurites and involved in kinesin-mediated transport in neurons.

Purohit P, Perez-Branguli F, Prots I, Borger E, Gunn-Moore F, Welzel O, Loy K, Wenzel EM, Grömer TW, Brachs S, Holzer M, Buslei R, Fritsch K, Regensburger M, Böhm KJ, Winner B, Mielenz D.

PLoS One. 2014 Aug 18;9(8):e103976. doi: 10.1371/journal.pone.0103976. eCollection 2014.

11.

Pin1 promotes degradation of Smad proteins and their interaction with phosphorylated tau in Alzheimer's disease.

Ueberham U, Rohn S, Ueberham E, Wodischeck S, Hilbrich I, Holzer M, Brückner MK, Gruschka H, Arendt T.

Neuropathol Appl Neurobiol. 2014 Dec;40(7):815-32. doi: 10.1111/nan.12163.

PMID:
24964035
12.

Axotrophin/MARCH7 acts as an E3 ubiquitin ligase and ubiquitinates tau protein in vitro impairing microtubule binding.

Flach K, Ramminger E, Hilbrich I, Arsalan-Werner A, Albrecht F, Herrmann L, Goedert M, Arendt T, Holzer M.

Biochim Biophys Acta. 2014 Sep;1842(9):1527-38. doi: 10.1016/j.bbadis.2014.05.029. Epub 2014 Jun 4.

13.

Tau oligomers impair artificial membrane integrity and cellular viability.

Flach K, Hilbrich I, Schiffmann A, Gärtner U, Krüger M, Leonhardt M, Waschipky H, Wick L, Arendt T, Holzer M.

J Biol Chem. 2012 Dec 21;287(52):43223-33. doi: 10.1074/jbc.M112.396176. Epub 2012 Nov 5.

14.

Multitargeted drug development: Discovery and profiling of dihydroxy substituted 1-aza-9-oxafluorenes as lead compounds targeting Alzheimer disease relevant kinases.

Tell V, Holzer M, Herrmann L, Mahmoud KA, Schächtele C, Totzke F, Hilgeroth A.

Bioorg Med Chem Lett. 2012 Nov 15;22(22):6914-8. doi: 10.1016/j.bmcl.2012.09.006. Epub 2012 Sep 13.

PMID:
23039927
15.

A family of protein-deglutamylating enzymes associated with neurodegeneration.

Rogowski K, van Dijk J, Magiera MM, Bosc C, Deloulme JC, Bosson A, Peris L, Gold ND, Lacroix B, Bosch Grau M, Bec N, Larroque C, Desagher S, Holzer M, Andrieux A, Moutin MJ, Janke C.

Cell. 2010 Nov 12;143(4):564-78. doi: 10.1016/j.cell.2010.10.014.

16.

Expression of the embryonal isoform (0N/3R) of the microtubule-associated protein tau in the adult rat central nervous system.

Bullmann T, Härtig W, Holzer M, Arendt T.

J Comp Neurol. 2010 Jul 1;518(13):2538-53. doi: 10.1002/cne.22351.

PMID:
20503426
17.

Pattern of tau isoforms expression during development in vivo.

Bullmann T, Holzer M, Mori H, Arendt T.

Int J Dev Neurosci. 2009 Oct;27(6):591-7. doi: 10.1016/j.ijdevneu.2009.06.001. Epub 2009 Jun 18.

PMID:
19540327
18.

A putative role for cell cycle-related proteins in microtubule-based neuroplasticity.

Schmetsdorf S, Arnold E, Holzer M, Arendt T, Gärtner U.

Eur J Neurosci. 2009 Mar;29(6):1096-107. doi: 10.1111/j.1460-9568.2009.06661.x.

PMID:
19302146
19.

Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology.

Schilling S, Zeitschel U, Hoffmann T, Heiser U, Francke M, Kehlen A, Holzer M, Hutter-Paier B, Prokesch M, Windisch M, Jagla W, Schlenzig D, Lindner C, Rudolph T, Reuter G, Cynis H, Montag D, Demuth HU, Rossner S.

Nat Med. 2008 Oct;14(10):1106-11. doi: 10.1038/nm.1872. Epub 2008 Sep 28.

PMID:
18836460
20.

Analysis of tau phosphorylation and truncation in a mouse model of human tauopathy.

Delobel P, Lavenir I, Fraser G, Ingram E, Holzer M, Ghetti B, Spillantini MG, Crowther RA, Goedert M.

Am J Pathol. 2008 Jan;172(1):123-31. Epub 2007 Dec 13.

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