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Items: 1 to 20 of 42

1.

Mitochondrial dysfunction increases fatty acid β-oxidation and translates into impaired neuroblast maturation.

Audano M, Pedretti S, Crestani M, Caruso D, De Fabiani E, Mitro N.

FEBS Lett. 2019 Aug 21. doi: 10.1002/1873-3468.13584. [Epub ahead of print]

PMID:
31432511
2.

Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation.

Laghezza A, Piemontese L, Cerchia C, Montanari R, Capelli D, Giudici M, Crestani M, Tortorella P, Peiretti F, Pochetti G, Lavecchia A, Loiodice F.

J Med Chem. 2018 Sep 27;61(18):8282-8298. doi: 10.1021/acs.jmedchem.8b00835. Epub 2018 Sep 18.

PMID:
30199253
3.

Epigenome modifiers and metabolic rewiring: New frontiers in therapeutics.

Ferrari A, Longo R, Silva R, Mitro N, Caruso D, De Fabiani E, Crestani M.

Pharmacol Ther. 2019 Jan;193:178-193. doi: 10.1016/j.pharmthera.2018.08.008. Epub 2018 Aug 17. Review.

PMID:
30125527
4.

Zc3h10 is a novel mitochondrial regulator.

Audano M, Pedretti S, Cermenati G, Brioschi E, Diaferia GR, Ghisletti S, Cuomo A, Bonaldi T, Salerno F, Mora M, Grigore L, Garlaschelli K, Baragetti A, Bonacina F, Catapano AL, Norata GD, Crestani M, Caruso D, Saez E, De Fabiani E, Mitro N.

EMBO Rep. 2018 Apr;19(4). pii: e45531. doi: 10.15252/embr.201745531. Epub 2018 Mar 5.

5.

Fenofibrate attenuates cardiac and renal alterations in young salt-loaded spontaneously hypertensive stroke-prone rats through mitochondrial protection.

Castiglioni L, Pignieri A, Fiaschè M, Giudici M, Crestani M, Mitro N, Abbate M, Zoja C, Rottoli D, Foray C, Fiordaliso F, Guerrini U, Tremoli E, Sironi L, Gelosa P.

J Hypertens. 2018 May;36(5):1129-1146. doi: 10.1097/HJH.0000000000001651.

PMID:
29278547
6.

HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning.

Ferrari A, Longo R, Fiorino E, Silva R, Mitro N, Cermenati G, Gilardi F, Desvergne B, Andolfo A, Magagnotti C, Caruso D, Fabiani E, Hiebert SW, Crestani M.

Nat Commun. 2017 Jul 21;8(1):93. doi: 10.1038/s41467-017-00182-7.

7.

Of mice and humans through the looking glass: "reflections" on epigenetics of lipid metabolism.

Longo R, Ferrari A, Zocchi M, Crestani M.

Mol Aspects Med. 2017 Apr;54:16-27. doi: 10.1016/j.mam.2017.01.005. Epub 2017 Jan 22. Review.

8.

An Essential Role for Liver ERα in Coupling Hepatic Metabolism to the Reproductive Cycle.

Della Torre S, Mitro N, Fontana R, Gomaraschi M, Favari E, Recordati C, Lolli F, Quagliarini F, Meda C, Ohlsson C, Crestani M, Uhlenhaut NH, Calabresi L, Maggi A.

Cell Rep. 2016 Apr 12;15(2):360-71. doi: 10.1016/j.celrep.2016.03.019. Epub 2016 Mar 31.

9.

Chlamydia pneumoniae acute liver infection affects hepatic cholesterol and triglyceride metabolism in mice.

Marangoni A, Fiorino E, Gilardi F, Aldini R, Scotti E, Nardini P, Foschi C, Donati M, Montagnani M, Cevenini M, Franco P, Roda A, Crestani M, Cevenini R.

Atherosclerosis. 2015 Aug;241(2):471-9. doi: 10.1016/j.atherosclerosis.2015.05.023. Epub 2015 Jun 3.

PMID:
26086356
10.

Lack of sterol regulatory element binding factor-1c imposes glial Fatty Acid utilization leading to peripheral neuropathy.

Cermenati G, Audano M, Giatti S, Carozzi V, Porretta-Serapiglia C, Pettinato E, Ferri C, D'Antonio M, De Fabiani E, Crestani M, Scurati S, Saez E, Azcoitia I, Cavaletti G, Garcia-Segura LM, Melcangi RC, Caruso D, Mitro N.

Cell Metab. 2015 Apr 7;21(4):571-83. doi: 10.1016/j.cmet.2015.02.016. Epub 2015 Mar 26.

11.

Olive oil phenolic extract regulates interleukin-8 expression by transcriptional and posttranscriptional mechanisms in Caco-2 cells.

Muto E, Dell'Agli M, Sangiovanni E, Mitro N, Fumagalli M, Crestani M, De Fabiani E, Caruso D.

Mol Nutr Food Res. 2015 Jun;59(6):1217-21. doi: 10.1002/mnfr.201400800. Epub 2015 Apr 27.

PMID:
25708117
12.

Energizing Genetics and Epi-genetics: Role in the Regulation of Mitochondrial Function.

Audano M, Ferrari A, Fiorino E, Kuenzl M, Caruso D, Mitro N, Crestani M, De Fabiani E.

Curr Genomics. 2014 Dec;15(6):436-56. doi: 10.2174/138920291506150106151119.

13.

The lipogenic regulator Sterol Regulatory Element Binding Factor-1c is required to maintain peripheral nerve structure and function.

Mitro N, Cermenati G, Audano M, Giatti S, D'Antonio M, Fabiani ED, Crestani M, Saez E, Azcoitia I, Cavaletti G, Garcia-Segura LM, Melcangi RC, Caruso D.

Springerplus. 2015 Jun 12;4(Suppl 1):L45. doi: 10.1186/2193-1801-4-S1-L45. eCollection 2015. No abstract available.

14.

Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor α/γ ligand LT175.

Piemontese L, Fracchiolla G, Carrieri A, Parente M, Laghezza A, Carbonara G, Sblano S, Tauro M, Gilardi F, Tortorella P, Lavecchia A, Crestani M, Desvergne B, Loiodice F.

Eur J Med Chem. 2015 Jan 27;90:583-94. doi: 10.1016/j.ejmech.2014.11.044. Epub 2014 Nov 24.

PMID:
25497132
15.

Linking transcription to physiology in lipidomics.

Crestani M, Moschetta A.

Biochim Biophys Acta. 2015 Jan;1851(1):1. doi: 10.1016/j.bbalip.2014.11.001. Epub 2014 Nov 6. No abstract available.

PMID:
25449651
16.

Lipids in the nervous system: from biochemistry and molecular biology to patho-physiology.

Cermenati G, Mitro N, Audano M, Melcangi RC, Crestani M, De Fabiani E, Caruso D.

Biochim Biophys Acta. 2015 Jan;1851(1):51-60. doi: 10.1016/j.bbalip.2014.08.011. Epub 2014 Aug 20. Review.

PMID:
25150974
17.

Neuroactive steroid treatment modulates myelin lipid profile in diabetic peripheral neuropathy.

Mitro N, Cermenati G, Brioschi E, Abbiati F, Audano M, Giatti S, Crestani M, De Fabiani E, Azcoitia I, Garcia-Segura LM, Caruso D, Melcangi RC.

J Steroid Biochem Mol Biol. 2014 Sep;143:115-21. doi: 10.1016/j.jsbmb.2014.02.015. Epub 2014 Mar 4.

PMID:
24607810
18.

The sirtuin class of histone deacetylases: regulation and roles in lipid metabolism.

Fiorino E, Giudici M, Ferrari A, Mitro N, Caruso D, De Fabiani E, Crestani M.

IUBMB Life. 2014 Feb;66(2):89-99. doi: 10.1002/iub.1246. Epub 2014 Feb 3. Review.

19.

LT175 is a novel PPARα/γ ligand with potent insulin-sensitizing effects and reduced adipogenic properties.

Gilardi F, Giudici M, Mitro N, Maschi O, Guerrini U, Rando G, Maggi A, Cermenati G, Laghezza A, Loiodice F, Pochetti G, Lavecchia A, Caruso D, De Fabiani E, Bamberg K, Crestani M.

J Biol Chem. 2014 Mar 7;289(10):6908-20. doi: 10.1074/jbc.M113.506394. Epub 2014 Jan 22.

20.

Molecular determinants for nuclear receptors selectivity: chemometric analysis, dockings and site-directed mutagenesis of dual peroxisome proliferator-activated receptors α/γ agonists.

Carrieri A, Giudici M, Parente M, De Rosas M, Piemontese L, Fracchiolla G, Laghezza A, Tortorella P, Carbonara G, Lavecchia A, Gilardi F, Crestani M, Loiodice F.

Eur J Med Chem. 2013 May;63:321-32. doi: 10.1016/j.ejmech.2013.02.015. Epub 2013 Feb 24.

PMID:
23502212

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