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Items: 1 to 20 of 75


Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons.

Barnes IHA, Ibarra-Soria X, Fitzgerald S, Gonzalez JM, Davidson C, Hardy MP, Manthravadi D, Van Gerven L, Jorissen M, Zeng Z, Khan M, Mombaerts P, Harrow J, Logan DW, Frankish A.

BMC Genomics. 2020 Mar 3;21(1):196. doi: 10.1186/s12864-020-6583-3.


Glycoproteomic measurement of site-specific polysialylation.

Pelingon R, Pegg CL, Zacchi LF, Phung TK, Howard CB, Xu P, Hardy MP, Owczarek CM, Schulz BL.

Anal Biochem. 2020 Feb 20;596:113625. doi: 10.1016/j.ab.2020.113625. [Epub ahead of print]


Optimizing high throughput antibody purification by using continuous chromatography media.

Butcher RE, Martin-Roussety G, Bradford RA, Tester A, Owczarek C, Hardy MP, Chen CG, Sansome G, Fabri LJ, Schmidt PM.

Protein Expr Purif. 2019 Jul;159:75-82. doi: 10.1016/j.pep.2019.03.011. Epub 2019 Mar 25.


Mining the Plasma Cell Transcriptome for Novel Cell Surface Proteins.

Trezise S, Karnowski A, Fedele PL, Mithraprabhu S, Liao Y, D'Costa K, Kueh AJ, Hardy MP, Owczarek CM, Herold MJ, Spencer A, Shi W, Willis SN, Nutt SL, Corcoran LM.

Int J Mol Sci. 2018 Jul 24;19(8). pii: E2161. doi: 10.3390/ijms19082161.


Phenotype-specific recombinant haptoglobin polymers co-expressed with C1r-like protein as optimized hemoglobin-binding therapeutics.

Schaer CA, Owczarek C, Deuel JW, Schauer S, Baek JH, Yalamanoglu A, Hardy MP, Scotney PD, Schmidt PM, Pelzing M, Soupourmas P, Buehler PW, Schaer DJ.

BMC Biotechnol. 2018 Mar 15;18(1):15. doi: 10.1186/s12896-018-0424-3.


A dual role for the N-terminal domain of the IL-3 receptor in cell signalling.

Broughton SE, Hercus TR, Nero TL, Kan WL, Barry EF, Dottore M, Cheung Tung Shing KS, Morton CJ, Dhagat U, Hardy MP, Wilson NJ, Downton MT, Schieber C, Hughes TP, Lopez AF, Parker MW.

Nat Commun. 2018 Jan 26;9(1):386. doi: 10.1038/s41467-017-02633-7.


An Optimized Hepatitis C Virus E2 Glycoprotein Core Adopts a Functional Homodimer That Efficiently Blocks Virus Entry.

McCaffrey K, Boo I, Owczarek CM, Hardy MP, Perugini MA, Fabri L, Scotney P, Poumbourios P, Drummer HE.

J Virol. 2017 Feb 14;91(5). pii: e01668-16. doi: 10.1128/JVI.01668-16. Print 2017 Mar 1.


The core domain of hepatitis C virus glycoprotein E2 generates potent cross-neutralizing antibodies in guinea pigs.

Vietheer PT, Boo I, Gu J, McCaffrey K, Edwards S, Owczarek C, Hardy MP, Fabri L, Center RJ, Poumbourios P, Drummer HE.

Hepatology. 2017 Apr;65(4):1117-1131. doi: 10.1002/hep.28989. Epub 2017 Feb 14.


A robust robotic high-throughput antibody purification platform.

Schmidt PM, Abdo M, Butcher RE, Yap MY, Scotney PD, Ramunno ML, Martin-Roussety G, Owczarek C, Hardy MP, Chen CG, Fabri LJ.

J Chromatogr A. 2016 Jul 15;1455:9-19. doi: 10.1016/j.chroma.2016.05.076. Epub 2016 May 24.


CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common β chain of the IL-3, GM-CSF and IL-5 receptors.

Panousis C, Dhagat U, Edwards KM, Rayzman V, Hardy MP, Braley H, Gauvreau GM, Hercus TR, Smith S, Sehmi R, McMillan L, Dottore M, McClure BJ, Fabri LJ, Vairo G, Lopez AF, Parker MW, Nash AD, Wilson NJ, Wilson MJ, Owczarek CM.

MAbs. 2016;8(3):436-53. doi: 10.1080/19420862.2015.1119352. Epub 2015 Dec 14.


The combination of ISCOMATRIX adjuvant and TLR agonists induces regression of established solid tumors in vivo.

Silva A, Mount A, Krstevska K, Pejoski D, Hardy MP, Owczarek C, Scotney P, Maraskovsky E, Baz Morelli A.

J Immunol. 2015 Mar 1;194(5):2199-207. doi: 10.4049/jimmunol.1402228. Epub 2015 Feb 2.


Unexpected mechanisms of action for a cytokine receptor-blocking antibody.

Hercus TR, Broughton SE, Hardy MP, Nero TL, Wilson NJ, Parker MW, Lopez AF.

Mol Cell Oncol. 2014 Dec 31;1(4):e969129. doi: 10.4161/23288604.2014.969129. eCollection 2014 Oct-Dec.


Review of Azoospermia.

Wosnitzer M, Goldstein M, Hardy MP.

Spermatogenesis. 2014 Mar 31;4:e28218. eCollection 2014. Review.


Dual mechanism of interleukin-3 receptor blockade by an anti-cancer antibody.

Broughton SE, Hercus TR, Hardy MP, McClure BJ, Nero TL, Dottore M, Huynh H, Braley H, Barry EF, Kan WL, Dhagat U, Scotney P, Hartman D, Busfield SJ, Owczarek CM, Nash AD, Wilson NJ, Parker MW, Lopez AF.

Cell Rep. 2014 Jul 24;8(2):410-9. doi: 10.1016/j.celrep.2014.06.038. Epub 2014 Jul 17.


Identification of potent antagonist antibodies against mouse IL-13Rα1 using novel bioassays.

Edwards KM, Huynh H, Prasad R, McDonald A, Hardy MP, Scotney P, Owczarek CM, Busfield SJ, Panousis C, Wilson NJ.

J Immunol Methods. 2014 May;407:48-57. doi: 10.1016/j.jim.2014.03.019. Epub 2014 Apr 3.


Soluble IFN receptor potentiates in vivo type I IFN signaling and exacerbates TLR4-mediated septic shock.

Samarajiwa SA, Mangan NE, Hardy MP, Najdovska M, Dubach D, Braniff SJ, Owczarek CM, Hertzog PJ.

J Immunol. 2014 May 1;192(9):4425-35. doi: 10.4049/jimmunol.1302388. Epub 2014 Apr 2.


Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of antibody CSL362.

Broughton SE, Hercus TR, Nero TL, Dhagat U, Owczarek CM, Hardy MP, Fabri LJ, Scotney PD, Nash AD, Wilson NJ, Lopez AF, Parker MW.

Acta Crystallogr F Struct Biol Commun. 2014 Mar;70(Pt 3):358-61. doi: 10.1107/S2053230X14002593. Epub 2014 Feb 19.


A factor XIIa inhibitory antibody provides thromboprotection in extracorporeal circulation without increasing bleeding risk.

Larsson M, Rayzman V, Nolte MW, Nickel KF, Björkqvist J, Jämsä A, Hardy MP, Fries M, Schmidbauer S, Hedenqvist P, Broomé M, Pragst I, Dickneite G, Wilson MJ, Nash AD, Panousis C, Renné T.

Sci Transl Med. 2014 Feb 5;6(222):222ra17. doi: 10.1126/scitranslmed.3006804.


Parting messages from current and former editors of the Journal of Andrology.

Bartke A, Orgebin-Crist MC, Desjardins C, Lewis R, Tindall D, Hamilton DW, Pryor JL, Schlegel PN, Hardy MP, Burnett AL, Darney SP, Sandlow J.

J Androl. 2012 Nov-Dec;33(6):1068-74. doi: 10.2164/jandrol.112.017475. Epub 2012 Aug 9.


Role of 11β-OH-C(19) and C(21) steroids in the coupling of 11β-HSD1 and 17β-HSD3 in regulation of testosterone biosynthesis in rat Leydig cells.

Latif SA, Shen M, Ge RS, Sottas CM, Hardy MP, Morris DJ.

Steroids. 2011 Jun;76(7):682-9. doi: 10.1016/j.steroids.2011.03.007. Epub 2011 Apr 2.


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