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Items: 1 to 20 of 27


Evaluation of NV556, a Novel Cyclophilin Inhibitor, as a Potential Antifibrotic Compound for Liver Fibrosis.

Simón Serrano S, Grönberg A, Longato L, Rombouts K, Kuo J, Gregory M, Moss S, Elmér E, Mazza G, Gallay P, Pinzani M, Hansson MJ, Massoumi R.

Cells. 2019 Nov 8;8(11). pii: E1409. doi: 10.3390/cells8111409.


Multiscale divergence between Landsat- and lidar-based biomass mapping is related to regional variation in canopy cover and composition.

Bell DM, Gregory MJ, Kane V, Kane J, Kennedy RE, Roberts HM, Yang Z.

Carbon Balance Manag. 2018 Sep 14;13(1):15. doi: 10.1186/s13021-018-0104-6.


Diversity oriented biosynthesis via accelerated evolution of modular gene clusters.

Wlodek A, Kendrew SG, Coates NJ, Hold A, Pogwizd J, Rudder S, Sheehan LS, Higginbotham SJ, Stanley-Smith AE, Warneck T, Nur-E-Alam M, Radzom M, Martin CJ, Overvoorde L, Samborskyy M, Alt S, Heine D, Carter GT, Graziani EI, Koehn FE, McDonald L, Alanine A, Rodríguez Sarmiento RM, Chao SK, Ratni H, Steward L, Norville IH, Sarkar-Tyson M, Moss SJ, Leadlay PF, Wilkinson B, Gregory MA.

Nat Commun. 2017 Oct 31;8(1):1206. doi: 10.1038/s41467-017-01344-3.


Cumulative effects of wildfires on forest dynamics in the eastern Cascade Mountains, USA.

Reilly MJ, Elia M, Spies TA, Gregory MJ, Sanesi G, Lafortezza R.

Ecol Appl. 2018 Mar;28(2):291-308. doi: 10.1002/eap.1644. Epub 2018 Jan 19.


Modulation of topoisomerase IIα expression and chemosensitivity through targeted inhibition of NF-Y:DNA binding by a diamino p-anisyl-benzimidazole (Hx) polyamide.

Pett L, Kiakos K, Satam V, Patil P, Laughlin-Toth S, Gregory M, Bowerman M, Olson K, Savagian M, Lee M, Lee M, Wilson WD, Hochhauser D, Hartley JA.

Biochim Biophys Acta Gene Regul Mech. 2017 May;1860(5):617-629. doi: 10.1016/j.bbagrm.2016.10.005. Epub 2016 Oct 24.


An Efficient Method To Generate Gene Deletion Mutants of the Rapamycin-Producing Bacterium Streptomyces iranensis HM 35.

Netzker T, Schroeckh V, Gregory MA, Flak M, Krespach MKC, Leadlay PF, Brakhage AA.

Appl Environ Microbiol. 2016 May 31;82(12):3481-3492. doi: 10.1128/AEM.00371-16. Print 2016 Jun 15.


Multiplexed integrating plasmids for engineering of the erythromycin gene cluster for expression in Streptomyces spp. and combinatorial biosynthesis.

Fayed B, Ashford DA, Hashem AM, Amin MA, El Gazayerly ON, Gregory MA, Smith MC.

Appl Environ Microbiol. 2015 Dec;81(24):8402-13. doi: 10.1128/AEM.02403-15. Epub 2015 Oct 2.


Bioengineering and semisynthesis of an optimized cyclophilin inhibitor for treatment of chronic viral infection.

Hansson MJ, Moss SJ, Bobardt M, Chatterji U, Coates N, Garcia-Rivera JA, Elmér E, Kendrew S, Leyssen P, Neyts J, Nur-E-Alam M, Warneck T, Wilkinson B, Gallay P, Gregory MA.

Chem Biol. 2015 Feb 19;22(2):285-92. doi: 10.1016/j.chembiol.2014.10.023. Epub 2015 Jan 22.


Evolutionary relationships among actinophages and a putative adaptation for growth in Streptomyces spp.

Smith MC, Hendrix RW, Dedrick R, Mitchell K, Ko CC, Russell D, Bell E, Gregory M, Bibb MJ, Pethick F, Jacobs-Sera D, Herron P, Buttner MJ, Hatfull GF.

J Bacteriol. 2013 Nov;195(21):4924-35. doi: 10.1128/JB.00618-13. Epub 2013 Aug 30.


Hx-amides: DNA sequence recognition by the fluorescent Hx (p-anisylbenzimidazole)•pyrrole and Hx•imidazole pairings.

Satam V, Patil P, Babu B, Gregory M, Bowerman M, Savagian M, Lee M, Tzou S, Olson K, Liu Y, Ramos J, Wilson WD, Bingham JP, Kiakos K, Hartley JA, Lee M.

Bioorg Med Chem Lett. 2013 Mar 15;23(6):1699-702. doi: 10.1016/j.bmcl.2013.01.075. Epub 2013 Jan 25.


Development of a flow cytometry live cell assay for the screening of inhibitors of hepatitis C virus (HCV) replication.

Garcia-Rivera JA, Lin K, Hopkins S, Gregory MA, Wilkinson B, Gallay PA.

Open Virol J. 2012;6:97-102. doi: 10.2174/1874357901206010097. Epub 2012 Nov 26.


Recombinant strains for the enhanced production of bioengineered rapalogs.

Kendrew SG, Petkovic H, Gaisser S, Ready SJ, Gregory MA, Coates NJ, Nur-E-Alam M, Warneck T, Suthar D, Foster TA, McDonald L, Schlingman G, Koehn FE, Skotnicki JS, Carter GT, Moss SJ, Zhang MQ, Martin CJ, Sheridan RM, Wilkinson B.

Metab Eng. 2013 Jan;15:167-73. doi: 10.1016/j.ymben.2012.11.001. Epub 2012 Nov 17.


Multiple mutations in hepatitis C virus NS5A domain II are required to confer a significant level of resistance to alisporivir.

Garcia-Rivera JA, Bobardt M, Chatterji U, Hopkins S, Gregory MA, Wilkinson B, Lin K, Gallay PA.

Antimicrob Agents Chemother. 2012 Oct;56(10):5113-21. doi: 10.1128/AAC.00919-12. Epub 2012 Jul 16.


Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate.

Andexer JN, Kendrew SG, Nur-e-Alam M, Lazos O, Foster TA, Zimmermann AS, Warneck TD, Suthar D, Coates NJ, Koehn FE, Skotnicki JS, Carter GT, Gregory MA, Martin CJ, Moss SJ, Leadlay PF, Wilkinson B.

Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4776-81. doi: 10.1073/pnas.1015773108. Epub 2011 Mar 7. Erratum in: Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):8080.


Preclinical characterization of naturally occurring polyketide cyclophilin inhibitors from the sanglifehrin family.

Gregory MA, Bobardt M, Obeid S, Chatterji U, Coates NJ, Foster T, Gallay P, Leyssen P, Moss SJ, Neyts J, Nur-e-Alam M, Paeshuyse J, Piraee M, Suthar D, Warneck T, Zhang MQ, Wilkinson B.

Antimicrob Agents Chemother. 2011 May;55(5):1975-81. doi: 10.1128/AAC.01627-10. Epub 2011 Mar 7.


Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoforms.

Woolard J, Vousden W, Moss SJ, Krishnakumar A, Gammons MV, Nowak DG, Dixon N, Micklefield J, Spannhoff A, Bedford MT, Gregory MA, Martin CJ, Leadlay PF, Zhang MQ, Harper SJ, Bates DO, Wilkinson B.

Chem Sci. 2011 Feb 1;2011(2):273-278.


Optimizing natural products by biosynthetic engineering: discovery of nonquinone Hsp90 inhibitors.

Zhang MQ, Gaisser S, Nur-E-Alam M, Sheehan LS, Vousden WA, Gaitatzis N, Peck G, Coates NJ, Moss SJ, Radzom M, Foster TA, Sheridan RM, Gregory MA, Roe SM, Prodromou C, Pearl L, Boyd SM, Wilkinson B, Martin CJ.

J Med Chem. 2008 Sep 25;51(18):5494-7. doi: 10.1021/jm8006068.


Molecular characterization of macbecin as an Hsp90 inhibitor.

Martin CJ, Gaisser S, Challis IR, Carletti I, Wilkinson B, Gregory M, Prodromou C, Roe SM, Pearl LH, Boyd SM, Zhang MQ.

J Med Chem. 2008 May 8;51(9):2853-7. doi: 10.1021/jm701558c. Epub 2008 Mar 22.


Influence of environment, disturbance, and ownership on forest vegetation of coastal Oregon.

Ohmann JL, Gregory MJ, Spies TA.

Ecol Appl. 2007 Jan;17(1):18-33.


Rapamycin biosynthesis: Elucidation of gene product function.

Gregory MA, Hong H, Lill RE, Gaisser S, Petkovic H, Low L, Sheehan LS, Carletti I, Ready SJ, Ward MJ, Kaja AL, Weston AJ, Challis IR, Leadlay PF, Martin CJ, Wilkinson B, Sheridan RM.

Org Biomol Chem. 2006 Oct 7;4(19):3565-8. Epub 2006 Aug 22.


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