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Items: 1 to 20 of 28


Modeling drug exposure in rodents using e-cigarettes and other electronic nicotine delivery systems.

Miliano C, Scott ER, Murdaugh LB, Gnatowski ER, Faunce CL, Anderson MS, Reyes MM, Gregus AM, Buczynski MW.

J Neurosci Methods. 2019 Oct 12;330:108458. doi: 10.1016/j.jneumeth.2019.108458. [Epub ahead of print] Review.


From Synapse to Function: A Perspective on the Role of Neuroproteomics in Elucidating Mechanisms of Drug Addiction.

Natividad LA, Buczynski MW, McClatchy DB, Yates JR 3rd.

Proteomes. 2018 Dec 9;6(4). pii: E50. doi: 10.3390/proteomes6040050. Review.


Inhibition of spinal 15-LOX-1 attenuates TLR4-dependent, nonsteroidal anti-inflammatory drug-unresponsive hyperalgesia in male rats.

Gregus AM, Buczynski MW, Dumlao DS, Norris PC, Rai G, Simeonov A, Maloney DJ, Jadhav A, Xu Q, Wei SC, Fitzsimmons BL, Dennis EA, Yaksh TL.

Pain. 2018 Dec;159(12):2620-2629. doi: 10.1097/j.pain.0000000000001373.


Loren Parsons' contribution to addiction neurobiology.

De Luca MA, Buczynski MW, Di Chiara G.

Addict Biol. 2018 Nov;23(6):1207-1222. doi: 10.1111/adb.12642. Epub 2018 Jun 27.


Deficient endocannabinoid signaling in the central amygdala contributes to alcohol dependence-related anxiety-like behavior and excessive alcohol intake.

Serrano A, Pavon FJ, Buczynski MW, Schlosburg J, Natividad LA, Polis IY, Stouffer DG, Zorrilla EP, Roberto M, Cravatt BF, Martin-Fardon R, Rodriguez de Fonseca F, Parsons LH.

Neuropsychopharmacology. 2018 Aug;43(9):1840-1850. doi: 10.1038/s41386-018-0055-3. Epub 2018 Apr 5.


Phosphorylation of calcium/calmodulin-dependent protein kinase II in the rat dorsal medial prefrontal cortex is associated with alcohol-induced cognitive inflexibility.

Natividad LA, Steinman MQ, Laredo SA, Irimia C, Polis IY, Lintz R, Buczynski MW, Martin-Fardon R, Roberto M, Parsons LH.

Addict Biol. 2018 Sep;23(5):1117-1129. doi: 10.1111/adb.12568. Epub 2017 Sep 22.


Constitutive Increases in Amygdalar Corticotropin-Releasing Factor and Fatty Acid Amide Hydrolase Drive an Anxious Phenotype.

Natividad LA, Buczynski MW, Herman MA, Kirson D, Oleata CS, Irimia C, Polis I, Ciccocioppo R, Roberto M, Parsons LH.

Biol Psychiatry. 2017 Oct 1;82(7):500-510. doi: 10.1016/j.biopsych.2017.01.005. Epub 2017 Jan 13.


Dysregulated Glycine Signaling Contributes to Increased Impulsivity during Protracted Alcohol Abstinence.

Irimia C, Buczynski MW, Natividad LA, Laredo SA, Avalos N, Parsons LH.

J Neurosci. 2017 Feb 15;37(7):1853-1861. doi: 10.1523/JNEUROSCI.2466-16.2017.


Diacylglycerol lipase disinhibits VTA dopamine neurons during chronic nicotine exposure.

Buczynski MW, Herman MA, Hsu KL, Natividad LA, Irimia C, Polis IY, Pugh H, Chang JW, Niphakis MJ, Cravatt BF, Roberto M, Parsons LH.

Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):1086-91. doi: 10.1073/pnas.1522672113. Epub 2016 Jan 11.


Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss.

Talantova M, Sanz-Blasco S, Zhang X, Xia P, Akhtar MW, Okamoto S, Dziewczapolski G, Nakamura T, Cao G, Pratt AE, Kang YJ, Tu S, Molokanova E, McKercher SR, Hires SA, Sason H, Stouffer DG, Buczynski MW, Solomon JP, Michael S, Powers ET, Kelly JW, Roberts A, Tong G, Fang-Newmeyer T, Parker J, Holland EA, Zhang D, Nakanishi N, Chen HS, Wolosker H, Wang Y, Parsons LH, Ambasudhan R, Masliah E, Heinemann SF, Piña-Crespo JC, Lipton SA.

Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):E2518-27. doi: 10.1073/pnas.1306832110. Epub 2013 Jun 17. Erratum in: Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13691. Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):E3630. Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):E3751-2.


Evaluation of NHS carbamates as a potent and selective class of endocannabinoid hydrolase inhibitors.

Niphakis MJ, Cognetta AB 3rd, Chang JW, Buczynski MW, Parsons LH, Byrne F, Burston JJ, Chapman V, Cravatt BF.

ACS Chem Neurosci. 2013 Sep 18;4(9):1322-32. doi: 10.1021/cn400116z. Epub 2013 Jun 17.


Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia.

Gregus AM, Dumlao DS, Wei SC, Norris PC, Catella LC, Meyerstein FG, Buczynski MW, Steinauer JJ, Fitzsimmons BL, Yaksh TL, Dennis EA.

FASEB J. 2013 May;27(5):1939-49. doi: 10.1096/fj.12-217414. Epub 2013 Feb 4.


The volitional nature of nicotine exposure alters anandamide and oleoylethanolamide levels in the ventral tegmental area.

Buczynski MW, Polis IY, Parsons LH.

Neuropsychopharmacology. 2013 Mar;38(4):574-84. doi: 10.1038/npp.2012.210. Epub 2012 Nov 21.


Effect of ambient temperature on the thermoregulatory and locomotor stimulant effects of 4-methylmethcathinone in Wistar and Sprague-Dawley rats.

Wright MJ Jr, Angrish D, Aarde SM, Barlow DJ, Buczynski MW, Creehan KM, Vandewater SA, Parsons LH, Houseknecht KL, Dickerson TJ, Taffe MA.

PLoS One. 2012;7(8):e44652. doi: 10.1371/journal.pone.0044652. Epub 2012 Aug 31.


Adolescent rats are resistant to adaptations in excitatory and inhibitory mechanisms that modulate mesolimbic dopamine during nicotine withdrawal.

Natividad LA, Buczynski MW, Parsons LH, Torres OV, O'Dell LE.

J Neurochem. 2012 Nov;123(4):578-88. doi: 10.1111/j.1471-4159.2012.07926.x. Epub 2012 Oct 1.


Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates.

Chang JW, Niphakis MJ, Lum KM, Cognetta AB 3rd, Wang C, Matthews ML, Niessen S, Buczynski MW, Parsons LH, Cravatt BF.

Chem Biol. 2012 May 25;19(5):579-88. doi: 10.1016/j.chembiol.2012.03.009. Epub 2012 Apr 26.


Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors.

Gregus AM, Doolen S, Dumlao DS, Buczynski MW, Takasusuki T, Fitzsimmons BL, Hua XY, Taylor BK, Dennis EA, Yaksh TL.

Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6721-6. doi: 10.1073/pnas.1110460109. Epub 2012 Apr 9.


High-throughput lipidomic analysis of fatty acid derived eicosanoids and N-acylethanolamines.

Dumlao DS, Buczynski MW, Norris PC, Harkewicz R, Dennis EA.

Biochim Biophys Acta. 2011 Nov;1811(11):724-36. doi: 10.1016/j.bbalip.2011.06.005. Epub 2011 Jun 13.


Quantification of brain endocannabinoid levels: methods, interpretations and pitfalls.

Buczynski MW, Parsons LH.

Br J Pharmacol. 2010 Jun;160(3):423-42. doi: 10.1111/j.1476-5381.2010.00787.x. Review.


Inflammatory hyperalgesia induces essential bioactive lipid production in the spinal cord.

Buczynski MW, Svensson CI, Dumlao DS, Fitzsimmons BL, Shim JH, Scherbart TJ, Jacobsen FE, Hua XY, Yaksh TL, Dennis EA.

J Neurochem. 2010 Aug;114(4):981-93. doi: 10.1111/j.1471-4159.2010.06815.x. Epub 2010 May 14.

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