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Items: 1 to 20 of 44


Optimization of EphA2 antagonists based on a lithocholic acid core led to the identification of UniPR505, a new 3α-carbamoyloxy derivative with antiangiogenetic properties.

Incerti M, Russo S, Corrado M, Giorgio C, Ballabeni V, Chiodelli P, Rusnati M, Scalvini L, Callegari D, Castelli R, Vacondio F, Ferlenghi F, Tognolini M, Lodola A.

Eur J Med Chem. 2020 Mar 1;189:112083. doi: 10.1016/j.ejmech.2020.112083. Epub 2020 Jan 22.


New N-(2-phenyl-4-oxo-1,3-thiazolidin-3-yl)-1,2-benzothiazole-3-carboxamides and acetamides as antimicrobial agents.

Incerti M, Vicini P, Geronikaki A, Eleftheriou P, Tsagkadouras A, Zoumpoulakis P, Fotakis C, Ćirić A, Glamočlija J, Soković M.

Medchemcomm. 2017 Nov 3;8(11):2142-2154. doi: 10.1039/c7md00334j. eCollection 2017 Nov 1.


4-Thiazolidinone Derivatives as MMP Inhibitors in Tissue Damage: Synthesis, Biological Evaluation and Docking Studies.

Incerti M, Crascì L, Vicini P, Aki E, Yalcin I, Ertan-Bolelli T, Cardile V, Graziano ACE, Panico A.

Molecules. 2018 Feb 14;23(2). pii: E415. doi: 10.3390/molecules23020415.


Pharmacological evaluation of new bioavailable small molecules targeting Eph/ephrin interaction.

Giorgio C, Incerti M, Corrado M, Rusnati M, Chiodelli P, Russo S, Callegari D, Ferlenghi F, Ballabeni V, Barocelli E, Lodola A, Tognolini M.

Biochem Pharmacol. 2018 Jan;147:21-29. doi: 10.1016/j.bcp.2017.11.002. Epub 2017 Nov 10.


Targeting Eph/ephrin system in cancer therapy.

Lodola A, Giorgio C, Incerti M, Zanotti I, Tognolini M.

Eur J Med Chem. 2017 Dec 15;142:152-162. doi: 10.1016/j.ejmech.2017.07.029. Epub 2017 Jul 18. Review.


Metadynamics for Perspective Drug Design: Computationally Driven Synthesis of New Protein-Protein Interaction Inhibitors Targeting the EphA2 Receptor.

Incerti M, Russo S, Callegari D, Pala D, Giorgio C, Zanotti I, Barocelli E, Vicini P, Vacondio F, Rivara S, Castelli R, Tognolini M, Lodola A.

J Med Chem. 2017 Jan 26;60(2):787-796. doi: 10.1021/acs.jmedchem.6b01642. Epub 2017 Jan 5.


Exploiting Free-Energy Minima to Design Novel EphA2 Protein-Protein Antagonists: From Simulation to Experiment and Return.

Russo S, Callegari D, Incerti M, Pala D, Giorgio C, Brunetti J, Bracci L, Vicini P, Barocelli E, Capoferri L, Rivara S, Tognolini M, Mor M, Lodola A.

Chemistry. 2016 Jun 6;22(24):8048-52. doi: 10.1002/chem.201600993. Epub 2016 May 3.


Biochemical characterization of EphA2 antagonists with improved physico-chemical properties by cell-based assays and surface plasmon resonance analysis.

Giorgio C, Russo S, Incerti M, Bugatti A, Vacondio F, Barocelli E, Mor M, Pala D, Hassan-Mohamed I, Gioiello A, Rusnati M, Lodola A, Tognolini M.

Biochem Pharmacol. 2016 Jan 1;99:18-30. doi: 10.1016/j.bcp.2015.10.006. Epub 2015 Oct 14.


Comparative Analysis of Virtual Screening Approaches in the Search for Novel EphA2 Receptor Antagonists.

Callegari D, Pala D, Scalvini L, Tognolini M, Incerti M, Rivara S, Mor M, Lodola A.

Molecules. 2015 Sep 17;20(9):17132-51. doi: 10.3390/molecules200917132.


Δ(5)-Cholenoyl-amino acids as selective and orally available antagonists of the Eph-ephrin system.

Castelli R, Tognolini M, Vacondio F, Incerti M, Pala D, Callegari D, Bertoni S, Giorgio C, Hassan-Mohamed I, Zanotti I, Bugatti A, Rusnati M, Festuccia C, Rivara S, Barocelli E, Mor M, Lodola A.

Eur J Med Chem. 2015 Oct 20;103:312-24. doi: 10.1016/j.ejmech.2015.08.048. Epub 2015 Aug 29.


2-Benzisothiazolylimino-5-benzylidene-4-thiazolidinones as protective agents against cartilage destruction.

Crascì L, Vicini P, Incerti M, Cardile V, Avondo S, Panico A.

Bioorg Med Chem. 2015 Apr 1;23(7):1551-6. doi: 10.1016/j.bmc.2015.02.002. Epub 2015 Feb 11.


Are we using the right pharmacological tools to target EphA4?

Tognolini M, Incerti M, Lodola A.

ACS Chem Neurosci. 2014 Dec 17;5(12):1146-7. doi: 10.1021/cn500285h. Epub 2014 Nov 18. Review.


Combining ligand- and structure-based approaches for the discovery of new inhibitors of the EPHA2-ephrin-A1 interaction.

Pala D, Castelli R, Incerti M, Russo S, Tognolini M, Giorgio C, Hassan-Mohamed I, Zanotti I, Vacondio F, Rivara S, Mor M, Lodola A.

J Chem Inf Model. 2014 Oct 27;54(10):2621-6. doi: 10.1021/ci5004619. Epub 2014 Oct 7.


On the use of 2,5-dimethyl-pyrrol-1-yl-benzoic acid derivatives as EPH-ephrin antagonists.

Lodola A, Incerti M, Tognolini M.

J Virol. 2014 Oct;88(20):12173. doi: 10.1128/JVI.02152-14. No abstract available.


A new efficient route to 7-aryl-6-fluoro-8-nitroquinolones as potent antibacterial agents.

Al-Trawneh SA, El-Abadelah MM, Al-Abadleh MM, Zani F, Incerti M, Vicini P.

Eur J Med Chem. 2014 Oct 30;86:364-7. doi: 10.1016/j.ejmech.2014.08.065. Epub 2014 Aug 26.


Design synthesis and antibacterial activity studies of new thiadiazoloquinolone compounds.

Al-Qawasmeh RA, Abadleh MM, Zahra JA, El-Abadelah MM, Albashiti R, Zani F, Incerti M, Vicini P.

J Enzyme Inhib Med Chem. 2014 Dec;29(6):777-85. doi: 10.3109/14756366.2013.855925. Epub 2014 Feb 10.


Synthesis and structure-activity relationships of amino acid conjugates of cholanic acid as antagonists of the EphA2 receptor.

Russo S, Incerti M, Tognolini M, Castelli R, Pala D, Hassan-Mohamed I, Giorgio C, De Franco F, Gioiello A, Vicini P, Barocelli E, Rivara S, Mor M, Lodola A.

Molecules. 2013 Oct 21;18(10):13043-60. doi: 10.3390/molecules181013043.


Target hopping as a useful tool for the identification of novel EphA2 protein-protein antagonists.

Tognolini M, Incerti M, Pala D, Russo S, Castelli R, Hassan-Mohamed I, Giorgio C, Lodola A.

ChemMedChem. 2014 Jan;9(1):67-72. doi: 10.1002/cmdc.201300305. Epub 2013 Sep 20.


Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor.

Incerti M, Tognolini M, Russo S, Pala D, Giorgio C, Hassan-Mohamed I, Noberini R, Pasquale EB, Vicini P, Piersanti S, Rivara S, Barocelli E, Mor M, Lodola A.

J Med Chem. 2013 Apr 11;56(7):2936-47. doi: 10.1021/jm301890k. Epub 2013 Mar 22.


Structure-activity relationships and mechanism of action of Eph-ephrin antagonists: interaction of cholanic acid with the EphA2 receptor.

Tognolini M, Incerti M, Hassan-Mohamed I, Giorgio C, Russo S, Bruni R, Lelli B, Bracci L, Noberini R, Pasquale EB, Barocelli E, Vicini P, Mor M, Lodola A.

ChemMedChem. 2012 Jun;7(6):1071-83. doi: 10.1002/cmdc.201200102. Epub 2012 Apr 23.

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