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Items: 1 to 20 of 33

1.

HIV-1 Integrase-Targeted Short Peptides Derived from a Viral Protein R Sequence.

Zhao XZ, Métifiot M, Kiselev E, Kessl JJ, Maddali K, Marchand C, Kvaratskhelia M, Pommier Y, Burke TR Jr.

Molecules. 2018 Jul 26;23(8). pii: E1858. doi: 10.3390/molecules23081858.

2.

Structure-Guided Optimization of HIV Integrase Strand Transfer Inhibitors.

Zhao XZ, Smith SJ, Maskell DP, Métifiot M, Pye VE, Fesen K, Marchand C, Pommier Y, Cherepanov P, Hughes SH, Burke TR Jr.

J Med Chem. 2017 Sep 14;60(17):7315-7332. doi: 10.1021/acs.jmedchem.7b00596. Epub 2017 Aug 10.

3.

De novo RNA synthesis catalyzed by the Zika Virus RNA polymerase domain.

Calmels C, Ventura M, Aknin C, Métifiot M, Andreola ML.

Sci Rep. 2017 Jun 2;7(1):2697. doi: 10.1038/s41598-017-03038-8.

4.

Selectivity for strand-transfer over 3'-processing and susceptibility to clinical resistance of HIV-1 integrase inhibitors are driven by key enzyme-DNA interactions in the active site.

Métifiot M, Johnson BC, Kiselev E, Marler L, Zhao XZ, Burke TR Jr, Marchand C, Hughes SH, Pommier Y.

Nucleic Acids Res. 2016 Aug 19;44(14):6896-906. doi: 10.1093/nar/gkw592. Epub 2016 Jul 1.

5.

HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases.

Zhao XZ, Smith SJ, Maskell DP, Metifiot M, Pye VE, Fesen K, Marchand C, Pommier Y, Cherepanov P, Hughes SH, Burke TR Jr.

ACS Chem Biol. 2016 Apr 15;11(4):1074-81. doi: 10.1021/acschembio.5b00948. Epub 2016 Feb 5.

6.

Synthesis of dihydropyrimidine α,γ-diketobutanoic acid derivatives targeting HIV integrase.

Sari O, Roy V, Métifiot M, Marchand C, Pommier Y, Bourg S, Bonnet P, Schinazi RF, Agrofoglio LA.

Eur J Med Chem. 2015 Nov 2;104:127-38. doi: 10.1016/j.ejmech.2015.09.015. Epub 2015 Sep 25.

7.

Anticancer molecule AS1411 exhibits low nanomolar antiviral activity against HIV-1.

Métifiot M, Amrane S, Mergny JL, Andreola ML.

Biochimie. 2015 Nov;118:173-5. doi: 10.1016/j.biochi.2015.09.009. Epub 2015 Sep 10.

PMID:
26363100
8.

6,7-Dihydroxyisoindolin-1-one and 7,8-Dihydroxy-3,4-Dihydroisoquinolin- 1(2H)-one Based HIV-1 Integrase Inhibitors.

Zhao XZ, Metifiot M, Smith SJ, Maddali K, Marchand C, Hughes SH, Pommier Y, Burke TR Jr.

Curr Top Med Chem. 2016;16(4):435-40. Review.

PMID:
26268341
9.

N-Substituted Quinolinonyl Diketo Acid Derivatives as HIV Integrase Strand Transfer Inhibitors and Their Activity against RNase H Function of Reverse Transcriptase.

Pescatori L, Métifiot M, Chung S, Masoaka T, Cuzzucoli Crucitti G, Messore A, Pupo G, Madia VN, Saccoliti F, Scipione L, Tortorella S, Di Leva FS, Cosconati S, Marinelli L, Novellino E, Le Grice SF, Pommier Y, Marchand C, Costi R, Di Santo R.

J Med Chem. 2015 Jun 11;58(11):4610-23. doi: 10.1021/acs.jmedchem.5b00159. Epub 2015 May 26.

PMID:
25961960
10.

Structure-activity relationship of pyrrolyl diketo acid derivatives as dual inhibitors of HIV-1 integrase and reverse transcriptase ribonuclease H domain.

Cuzzucoli Crucitti G, Métifiot M, Pescatori L, Messore A, Madia VN, Pupo G, Saccoliti F, Scipione L, Tortorella S, Esposito F, Corona A, Cadeddu M, Marchand C, Pommier Y, Tramontano E, Costi R, Di Santo R.

J Med Chem. 2015 Feb 26;58(4):1915-28. doi: 10.1021/jm501799k. Epub 2015 Feb 11.

PMID:
25629256
11.

G-quadruplexes in viruses: function and potential therapeutic applications.

Métifiot M, Amrane S, Litvak S, Andreola ML.

Nucleic Acids Res. 2014 Nov 10;42(20):12352-66. doi: 10.1093/nar/gku999. Epub 2014 Oct 20. Review.

12.

4-amino-1-hydroxy-2-oxo-1,8-naphthyridine-containing compounds having high potency against raltegravir-resistant integrase mutants of HIV-1.

Zhao XZ, Smith SJ, Métifiot M, Marchand C, Boyer PL, Pommier Y, Hughes SH, Burke TR Jr.

J Med Chem. 2014 Jun 26;57(12):5190-202. doi: 10.1021/jm5001908. Epub 2014 Jun 16. Erratum in: J Med Chem. 2014 Aug 14;57(15):6885.

13.

Basic quinolinonyl diketo acid derivatives as inhibitors of HIV integrase and their activity against RNase H function of reverse transcriptase.

Costi R, Métifiot M, Chung S, Cuzzucoli Crucitti G, Maddali K, Pescatori L, Messore A, Madia VN, Pupo G, Scipione L, Tortorella S, Di Leva FS, Cosconati S, Marinelli L, Novellino E, Le Grice SF, Corona A, Pommier Y, Marchand C, Di Santo R.

J Med Chem. 2014 Apr 24;57(8):3223-34. doi: 10.1021/jm5001503. Epub 2014 Apr 11.

14.

Bicyclic 1-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxamide-containing HIV-1 integrase inhibitors having high antiviral potency against cells harboring raltegravir-resistant integrase mutants.

Zhao XZ, Smith SJ, Métifiot M, Johnson BC, Marchand C, Pommier Y, Hughes SH, Burke TR Jr.

J Med Chem. 2014 Feb 27;57(4):1573-82. doi: 10.1021/jm401902n. Epub 2014 Feb 10.

15.

6-(1-Benzyl-1H-pyrrol-2-yl)-2,4-dioxo-5-hexenoic acids as dual inhibitors of recombinant HIV-1 integrase and ribonuclease H, synthesized by a parallel synthesis approach.

Costi R, Métifiot M, Esposito F, Cuzzucoli Crucitti G, Pescatori L, Messore A, Scipione L, Tortorella S, Zinzula L, Novellino E, Pommier Y, Tramontano E, Marchand C, Di Santo R.

J Med Chem. 2013 Nov 14;56(21):8588-98. doi: 10.1021/jm401040b. Epub 2013 Nov 5.

PMID:
24124919
16.

Cell-permeable stapled peptides based on HIV-1 integrase inhibitors derived from HIV-1 gene products.

Nomura W, Aikawa H, Ohashi N, Urano E, Métifiot M, Fujino M, Maddali K, Ozaki T, Nozue A, Narumi T, Hashimoto C, Tanaka T, Pommier Y, Yamamoto N, Komano JA, Murakami T, Tamamura H.

ACS Chem Biol. 2013 Oct 18;8(10):2235-44. doi: 10.1021/cb400495h. Epub 2013 Aug 15.

PMID:
23898787
17.

HIV integrase inhibitors: 20-year landmark and challenges.

Métifiot M, Marchand C, Pommier Y.

Adv Pharmacol. 2013;67:75-105. doi: 10.1016/B978-0-12-405880-4.00003-2. Review.

PMID:
23885999
18.

A homology model of HIV-1 integrase and analysis of mutations designed to test the model.

Johnson BC, Métifiot M, Ferris A, Pommier Y, Hughes SH.

J Mol Biol. 2013 Jun 26;425(12):2133-46. doi: 10.1016/j.jmb.2013.03.027. Epub 2013 Mar 27.

PMID:
23542006
19.

6,7-Dihydroxy-1-oxoisoindoline-4-sulfonamide-containing HIV-1 integrase inhibitors.

Zhao XZ, Maddali K, Smith SJ, Métifiot M, Johnson BC, Marchand C, Hughes SH, Pommier Y, Burke TR Jr.

Bioorg Med Chem Lett. 2012 Dec 15;22(24):7309-13. doi: 10.1016/j.bmcl.2012.10.088. Epub 2012 Oct 27.

20.

Activities, crystal structures, and molecular dynamics of dihydro-1H-isoindole derivatives, inhibitors of HIV-1 integrase.

Métifiot M, Maddali K, Johnson BC, Hare S, Smith SJ, Zhao XZ, Marchand C, Burke TR Jr, Hughes SH, Cherepanov P, Pommier Y.

ACS Chem Biol. 2013 Jan 18;8(1):209-17. doi: 10.1021/cb300471n. Epub 2012 Dec 24.

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