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J Diabetes Metab Disord. 2014 Oct 15;13(1):97. doi: 10.1186/s40200-014-0097-y. eCollection 2014.

Prevalence of diabetic peripheral neuropathy in Iran: a systematic review and meta-analysis.

Author information

1
Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
2
Department of Medical Emergencies, Qom University of Medical Sciences, Qom, Iran.
3
Elderly Health Research Center, Endocrinology and Metabolism Population Science Institute, Tehran University of Medical Sciences, Tehran, Iran.
4
Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran ; Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran ; Development of Research and Technology Center, Deputy of Research and Technology, Ministry of Health and Medical Education, Tehran, Iran.
5
Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran.
6
Department of Public Health, Ilam University of Medical Sciences, Ilam, Iran.
7
Hospital Management Research Center, Department of Health Economic, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran.
8
Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
9
Department of Community Medicine, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.

Abstract

Diabetic peripheral neuropathy (DPN) is an important microvascular complication of diabetes mellitus (DM). It is a major contributor to foot ulceration and lower limb amputation in persons with DM and have also a significant negative effect on patient's quality of life. This meta-analysis reviews prevalence of DPN among patients with type 1 and 2 DM in Iran. Using PubMed and NLM Gateway (for MEDLINE), Institute of Scientific Information (ISI), and SCOPUS as the main international electronic data sources, and Iranmedex, Irandoc, and Scientific Information Database (SID), as the main domestic databases with systematic search capability, we systematically searched surveys, papers, and reports on the prevalence of DPN (between January 1991 to February 2013). Heterogeneity of reported prevalence's between studies was assessed by the Chi-square-based Q test and due to heterogeneity; overall prevalence of DPN was estimated using random-effect meta-analysis model. We found 304 records; from them a total of 21 studies comprising 5540 diabetic patients were included. The prevalence of diabetic neuropathy (reported) from 16% to 87%. In overall the prevalence of DPN estimated 53% (95% CI: 41-65) by using random-effect. This study show that the prevalence of DPN seems very high among the population with diabetes in Iran and more than half of the patients with DM has any type of diabetic neuropathy.

KEYWORDS:

Diabetes mellitus; Diabetic peripheral neuropathy; Meta-analysis; Systematic review

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