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Molecules. 2011 Jun 17;16(6):5008-19. doi: 10.3390/molecules16065008.

Enantioselective Evans-Tishchenko reduction of β-hydroxyketone catalyzed by lithium binaphtholate.

Author information

1
Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto, Japan.

Abstract

Lithium diphenylbinaphtholate catalyzed the enantioselective Evans-Tishchenko reduction of achiral β-hydroxyketones to afford monoacyl-protected 1,3-diols with high stereoselectivities. In the reaction of racemic β-hydroxyketones, kinetic optical resolution occurred in a highly stereoselective manner.

PMID:
21694667
PMCID:
PMC6264331
DOI:
10.3390/molecules16065008
[Indexed for MEDLINE]
Free PMC Article

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